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Cited by 45 publications
(23 citation statements)
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References 48 publications
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“…Several clinical studies using G-CSF during the acute and subacute phase of ischemic stroke have now been reported [4]. At the acute phase of ischemic stroke, the question of combining G-CSF with tissue plasminogen activator (tPA), used for thrombolysis, is raised.…”
Section: Introductionmentioning
confidence: 99%
“…Several clinical studies using G-CSF during the acute and subacute phase of ischemic stroke have now been reported [4]. At the acute phase of ischemic stroke, the question of combining G-CSF with tissue plasminogen activator (tPA), used for thrombolysis, is raised.…”
Section: Introductionmentioning
confidence: 99%
“…Although the use of G-CSF in stroke patients failed to show significant benefit in Cochrane Database Systematic Review [31], animal studies using G-CSF still provide valuable insights on mechanism of stroke recovery and related potential therapeutics. We believe that investigation of angiogenesis, the important recovery mechanism after stroke, and its enhancement by external agent such as G-CSF is still a viable research theme worth exploring.…”
Section: Discussionmentioning
confidence: 99%
“…In three trials (n = 782), EPO was associated with a significant increase in death by the end of the trial. The evaluation of eight small trials (n = 548) of G-CSF showed a reduction in early impairment but no effect on functional outcome at the end of the trial [46]. The most recent multicenter RCT (n = 328) using G-CSF in the setting of acute stroke (B9-h time window) did not provide any significant benefit with respect to either clinical outcome or imaging, although there was a trend for reduced infarct growth in the G-CSF-treated group [47].…”
Section: Trophic Factorsmentioning
confidence: 97%
“…Two hematopoietic factors, granulocyte colony-stimulating factor (G-CSF) and erythropoietin (EPO), have been shown to have neuroprotective effects in experimental stroke models and to enhance neuronal plasticity [46]. A Cochrane review of colony-stimulating factors to treat patient with acute and subacute stroke identified 11 studies that fulfilled the selection criteria and involved 1275 participants.…”
Section: Trophic Factorsmentioning
confidence: 99%