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Cited by 206 publications
(210 citation statements)
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References 26 publications
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“…32 Only recently, the Transfusion Alternatives Preoperatively in SCD (TAPS) trial compared the outcomes of preoperative transfusion versus no preoperative transfusion in patients with HbSS or S␤ 0 thalassemia undergoing low-risk or medium-risk surgery in a prospective, randomized study. 33 This study, which was terminated early due to an imbalance of adverse events, demonstrated that preoperative transfusion is associated with decreased perioperative complications in patients with SCD, with 13 of 33 (39%) patients in the no preoperative transfusion group experiencing a clinically important complication compared with 5 of 34 (15%) patients who were transfused preoperatively. However, the TAPS trial was not able to address 2 major questions, what is the best preoperative management of individuals with other subtypes of SCD (HbSC or S␤ ϩ thalassemia) and what is the optimal management for low-risk procedures, due to the small number of enrolled patients (n ϭ 13) in this category.…”
Section: Preoperative Transfusionmentioning
confidence: 82%
“…32 Only recently, the Transfusion Alternatives Preoperatively in SCD (TAPS) trial compared the outcomes of preoperative transfusion versus no preoperative transfusion in patients with HbSS or S␤ 0 thalassemia undergoing low-risk or medium-risk surgery in a prospective, randomized study. 33 This study, which was terminated early due to an imbalance of adverse events, demonstrated that preoperative transfusion is associated with decreased perioperative complications in patients with SCD, with 13 of 33 (39%) patients in the no preoperative transfusion group experiencing a clinically important complication compared with 5 of 34 (15%) patients who were transfused preoperatively. However, the TAPS trial was not able to address 2 major questions, what is the best preoperative management of individuals with other subtypes of SCD (HbSC or S␤ ϩ thalassemia) and what is the optimal management for low-risk procedures, due to the small number of enrolled patients (n ϭ 13) in this category.…”
Section: Preoperative Transfusionmentioning
confidence: 82%
“…Patients were randomly allocated to transfusion to increase the hemoglobin concentration to Ͼ10 g/dL or no transfusion. 17 Clinically important complications occurred more frequently in patients who were not transfused (39%) than in patients who were transfused (15%). Nearly all of the complications were acute chest syndrome.…”
Section: Other Smaller Trialsmentioning
confidence: 98%
“…The benefits of prophylactic transfusion in SCD have been established for stroke prophylaxis 11 and as part of preoperative optimization. 12 However, the use of prophylactic transfusion beyond these indications is tempered by concerns over acute and delayed transfusion reactions, alloimmunization, transfusion-related infections, and iron overload. 13 Furthermore, reports assessing the effect of prophylactic RBC transfusions on pregnancy outcomes in SCD have been inconsistent.…”
Section: Introductionmentioning
confidence: 99%