2013
DOI: 10.1177/0363546512471299
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Abstract: A single dose of WBC-filtered PRP in concentrations of 10 times the normal amount is as effective as 2 injections to alleviate symptoms in early knee OA. The results, however, deteriorate after 6 months. Both groups treated with PRP had better results than did the group injected with saline only.

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Cited by 642 publications
(666 citation statements)
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“…As aforementioned, in a similar study in equine patients, the lameness improvement was most significant two months post-therapy and persisted for eight months (Carmona et al 2007). In most human studies, especially in young patients and in low-severity osteoarthritis, function improvement and control of pain were also stable for a shortterm period (usually six months) (Kon et al 2010;Patel et al 2013;Monteiro et al 2015). Since no side-effects were noticed in our study, one could postulate that repetitive treatments could only be to the best benefit of the equine patient.…”
Section: Discussionmentioning
confidence: 59%
See 1 more Smart Citation
“…As aforementioned, in a similar study in equine patients, the lameness improvement was most significant two months post-therapy and persisted for eight months (Carmona et al 2007). In most human studies, especially in young patients and in low-severity osteoarthritis, function improvement and control of pain were also stable for a shortterm period (usually six months) (Kon et al 2010;Patel et al 2013;Monteiro et al 2015). Since no side-effects were noticed in our study, one could postulate that repetitive treatments could only be to the best benefit of the equine patient.…”
Section: Discussionmentioning
confidence: 59%
“…Furthermore, in human patients with knee osteoarthritis, the use of intra-articular injections of various platelet-rich preparations as sources of growth factors resulted in significant clinical improvement and pain reduction up to 6 or 12 months post-treatment (Kon et al 2010;Filardo et al 2011). Similar results were reported when such treatment was compared with hyalunoral (S anchez et al 2008) or normal saline injections (Patel et al 2013). In an adolescent soccer player with a large avulsion of the articular cartilage of the knee, arthroscopic treatment with an autologous preparation rich in growth factors accelerated cartilage healing and resulted in an excellent clinical outcome and rapid resumption in athletic activity (S anchez et al 2003).…”
Section: Discussionmentioning
confidence: 60%
“…[62][63][64] The rationale for the use of Several studies have reported PRP to be clinically safe and effective in reducing pain following intra-articular injection of PRP up to 12 months following treatment. [66][67][68][69] Positive outcomes are mostly found more commonly in younger patients with Milles severe knee OA. In this subgroup of the population PRP does show clear benefit over hyaluronic acid in pain reduction and clinical function scores.…”
Section: Platelet-rich Plasma (Prp)mentioning
confidence: 99%
“…[66][67][68][69] Positive outcomes are mostly found more commonly in younger patients with Milles severe knee OA. In this subgroup of the population PRP does show clear benefit over hyaluronic acid in pain reduction and clinical function scores.…”
mentioning
confidence: 99%
“…Patel et al [21], in a level 1 evidence study comparing PRP and saline solution, assessed 78 patients with bilateral knee OA graded 1 or 2 according to the Ahlback classification [22]. They reported a statistically significant difference in favor of PRP with regard to pain, stiffness, and knee function; however, these outcomes were decreased after 6 months.…”
Section: Platelet-rich Plasmamentioning
confidence: 99%