Untitled

Tachi, Naoko; Hashimoto, Yoshihiro; Ogino, Nobuchika

doi:10.1023/a:1002432032354

Cited by 108 publications

(25 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We performed PPV in CRVO patients with macular edema because it was recently reported that PPV is a useful surgical technique for the treatment of macular edema due to CRVO and improvement of visual acuity [13,14]. In contrast, the Central Vein Occlusion Study Group concluded that treatments targeting the secondary effects of venous occlusion, such as grid laser photocoagulation for macular edema and prophylactic panretinal laser photocoagulation for nonperfused CRVO, fail to improve visual acuity [16].…”

Section: Discussionmentioning

confidence: 99%

“…The institutional review boards of the Tokyo Women’s Medical University and Hiroshima University both approved the protocol for the collection and testing of vitreous fluid. PPV was performed because it has been reported that macular edema and visual acuity can be improved in CRVO patients by this procedure [13,14]. Consecutive patients presenting with CRVO between June 2003 and August 2007 were screened according to the following criteria and 27 patients were enrolled.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema

et al. 2010

View full text Add to dashboard Cite

The outcome of vitrectomy for macular edema was examined in patients with central retinal vein occlusion (CRVO), as well as whether vascular endothelial growth factor (VEGF) and interleukin-6 (IL-6) levels in vitreous fluid influence the visual prognosis and macular edema. Twenty-six consecutive patients with CRVO and macular edema underwent vitrectomy. Best-corrected visual acuity, retinal thickness, and the VEGF and IL-6 levels in vitreous fluid were measured before and after surgery. Both visual acuity and retinal thickness were significantly improved at 6 months postoperatively (p = 0.0114 and p < 0.0001, respectively). The vitreous VEGF level was significantly higher in patients who showed less improvement of visual acuity (p = 0.0182). In contrast, a high vitreous VEGF level was associated with greater improvement of macular edema (p = 0.0199). These results suggest that the vitreous VEGF level may be correlated with the visual prognosis and changes of macular edema in CRVO patients after vitrectomy.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema

et al. 2010

View full text Add to dashboard Cite

show abstract

“…Recently, we were able to demonstrate that the posterior vitreous adhesion status may play a pivotal role in the development of CRVO [6]. Hence, the induction of a complete posterior vitreous detachment (PVD) offers a definite advantage for the involved patient as demonstrated in CRVO eyes undergoing pars plana vitrectomy [7]. Enzymatic vitreolysis as a novel approach can also be used to induce PVD development, and some major advantages have been attributed to the latter technique [8,9].…”

Section: Introductionmentioning

confidence: 99%

Intravitreal Functional Plasminogen Is Elevated in Central Retinal Vein Occlusion

Bertelmann

Mennel²,

Sekundo³

et al. 2013

Ophthalmic Res

View full text Add to dashboard Cite

Purpose: To detect intravitreal functional plasminogen in vitreous samples of patients with recent onset of central retinal vein occlusion (CRVO) and to demonstrate significantly higher intravitreal plasminogen in CRVO patients in comparison to controls. Methods: Prospective clinical case series of 13 consecutive patients with recent onset of CRVO scheduled for core pars plana vitrectomy and 10 consecutive patients undergoing standard pars plana vitrectomy for routine macular surgery or vitreal floater removal. In all 23 cases, vitreous taps were extracted from the central vitreous body, and plasminogen was functionally determined in a new ultrasensitive p-nitroanilide reaction after activation with streptokinase (100% of normal, %N = functional plasminogen in pooled normal citrated plasma). Results: Plasminogen was detected in all analyzed samples (n = 23), and mean plasminogen was revealed to be 1.33 ± 1.73% (mean ± SD), with a range of 0.03-7.8%N. Patients with recent onset of CRVO exhibited significantly higher intravitreal plasminogen (2.19 ± 1.89%N) in comparison to controls (0.20 ± 0.21%N; p < 0.001, Mann-Whitney U test). Conclusion: Due to significantly increased intravitreal plasminogen in patients with recent onset of CRVO, intravitreally administered tissue plasminogen activator might be an option to induce posterior vitreous detachment (enzymatic vitreolysis) in CRVO patients.

show abstract

“…Thus, it is possible that the key role in this surgery is played by the simple vitrectomy [82]. Pars plana vitrectomy with the creation of a posterior vitreous detachment was previously found to lead to a reduction in ME and a functional improvement in BRVO [83,84,85]. …”

Section: Treatmentmentioning

confidence: 99%

Branch Retinal Vein Occlusion: Classification and Treatment

Parodi

Bandello²

2009

Ophthalmologica

View full text Add to dashboard Cite

Branch retinal vein occlusion (BRVO) refers to a heterogeneous group of disorders with different clinical aspects, courses, and probably therapy. Depending on the site of the arteriovenous crossing, we can roughly divide BRVO into 3 main groups: major BRVO, hemispheric retinal vein occlusion, and macular BRVO. Main treatment options include laser treatment, corticosteroid administration, anti-VEGF drugs, and sheathotomy with or without vitrectomy. Laser photocoagulation, as demonstrated by the Branch Vein Occlusion Study, represents the gold standard for the treatment of macular edema and ocular neovascularization following BRVO. The limited functional outcomes achievable by means of laser treatment have prompted researchers to try alternative options, with varying results. The recent introduction of combined therapies for macular edema may provide a superior approach in an attempt to improve and stabilize visual acuity over a long-term follow-up.

show abstract

Untitled

Cited by 108 publications

References 2 publications

Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema

Visual Acuity and Foveal Thickness after Vitrectomy for Macular Edema

Intravitreal Functional Plasminogen Is Elevated in Central Retinal Vein Occlusion

Branch Retinal Vein Occlusion: Classification and Treatment

Contact Info

Product

Resources

About