21. Correlation between spleen size, platelet count and MELD score in cirrhosis

Yadav, Manoj Kumar; Devdas, Krishnadas; Mathew, Jose; Kv, Neeraj; Singh, Aniruddha Pratap

doi:10.1016/j.jceh.2018.06.382

Cited by 1 publication

(1 citation statement)

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“…2a, 3, 4). At this extent, we had a concordance with many studies [11,[23][24][25], but on the other hand, it was discordant with the Yadav et al study [26], who found (out of 112 patients) no significant correlation between MELD score and spleen size in cirrhosis. Kashani et al had explained this discordance, where the size of the spleen could vary between cirrhotic patients according to their primary disease etiologies, with hepatitis C virus (HCV) infected and non-alcoholic hepatitis patients were showing significantly larger organ dimensions as compared to those with alcoholic hepatitis [27], almost all of our patients lie in the category of post-infection (hepatitis) cirrhosis, where the splenomegaly was accordingly a harmonious feature.…”

Section: Discussionsupporting

confidence: 88%

Doppler ultrasound in liver cirrhosis: correlation of hepatic artery and portal vein measurements with model for end-stage liver disease score in Egypt

Baz

Mohamed

El-kaffas

2020

Egypt J Radiol Nucl Med

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Background Liver cirrhosis is a multi-etiological entity that alters the hepatic functions and vascularity by varying grades. Hereby, a cross-sectional study enrolling 100 cirrhotic patients (51 males and 49 females), who were diagnosed clinically and assessed by model for end-stage liver disease (MELD) score, then correlated to the hepatic Doppler parameters and ultrasound (US) findings of hepatic decompensation like ascites and splenomegaly. Results By Doppler and US, splenomegaly was evident in 49% of patients, while ascites was present in 44% of them. Increased hepatic artery velocity (HAV) was found in70% of cases, while 59% showed reduced portal vein velocity (PVV). There was a statistically significant correlation between HAV and MELD score (ρ = 0.000), but no significant correlation with either hepatic artery resistivity index (HARI) (ρ = 0.675) or PVV (ρ =0.266). Moreover, HAV had been correlated to splenomegaly (ρ = 0.000), whereas HARI (ρ = 0.137) and PVV (ρ = 0.241) did not significantly correlate. Also, ascites had correlated significantly to MELD score and HAV (ρ = 0.000), but neither HARI (ρ = 0.607) nor PVV (ρ = 0.143) was significantly correlated. Our results showed that HAV > 145 cm/s could confidently predict a high MELD score with 62.50% and 97.62 % sensitivity and specificity. Conclusion Doppler parameters of hepatic vessels (specifically HAV) in addition to the US findings of hepatic decompensation proved to be a non-invasive and cost-effective imaging tool for severity assessment in cirrhotic patients (scored by MELD); they could be used as additional prognostic parameters for improving the available treatment options and outcomes.

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