2077 Optimum fractionation for high dose rate intraluminal brachytherapy following external irradiation of superficial esophageal cancer

External beam radiation therapy with or without high-dose-rate intraluminal brachytherapy for patients with superficial esophageal carcinoma

“…Table 1 shows a summary of the literature on RT for superficial esophageal carcinoma. [12][13][14][15][16][17] Okawa et al 17 reported the clinical results of 105 patients with superficial esophageal carcinoma who were treated with definitive RT at 15 Japanese institutions between 1981 and 1990. In the multiinstitutional analysis, the 2-year local control rate was 83%, and the 5-year cause specific survival and overall survival rates were 71% and 39%, respectively.…”

“…The number of patients with superficial esophageal carcinoma treated by definitive RT has increased in Japan. [12][13][14][15][16][17] Since the introduction of a high dose rate (HDR) remote afterloading brachytherapy machine at Kyoto University Hospital, HDR intracavitary brachytherapy (IBT) has been used in the treatment of superficial esophageal carcinoma. Because superficial esophageal tumors are located within the depth of the esophageal mucosa, good spatial dose distribution of IBT may improve the clinical results.…”

High-dose-rate brachytherapy for previously irradiated patients with recurrent esophageal cancer

“…15 Furthermore, Akagi et al demonstrated that a higher HDRB fraction number (four or fi ve fractions) and lower fraction dose (2.0 or 2.5 Gy) reduces late complications while maintaining the effectiveness of treatment. 16 HDRB and concurrent chemotherapy has scarcely been studied. In a previous study, a combination of ERT, brachytherapy, and concurrent chemotherapy for patients with localized esophageal cancer increased the incidence of life-threatening or fatal esophagitis from 8% to 26%, and the incidence of treatment-related esophageal fi stula was 11%.…”