2001 Longterm follow-up of axillary node positive breast cancer patients receiving adjuvant systemic therapy alone: Patterns of recurrence

Fisher, Brandon J.; Perera, F.; Cooke, A.L.; Opeitum, A.

doi:10.1016/s0360-3016(97)85579-4

International Journal of Radiation Oncology*Biology*Physics

1996

DOI: 10.1016/s0360-3016(97)85579-4

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2001 Longterm follow-up of axillary node positive breast cancer patients receiving adjuvant systemic therapy alone: Patterns of recurrence

Brandon J. Fisher¹,

F. Perera²,

A.L. Cooke³

et al.

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2010

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“…Furthermore, there are variations in the radiation regimens used by different breast units and the optimal dose of adjuvant RT remains uncertain. The tumour-related risk factors associated with IBTR include increasing tumour size, 1,8,9 high histological grade, 1 positive lymph node status, 7,8 multicentric disease, 10 vascular invasion 11 and adverse biological factors such as tumoural p53 mutations. 10 In the Cambridge Breast Unit (CBU), BCS with a target radial margin of 5-mm for invasive breast cancer, in combination with hypofractionated 40-Gy whole breast RT regimen, has been used since 1999.…”

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confidence: 99%

Audit of local recurrence following breast conservation surgery with 5-mm target margin and hypofractionated 40-Gray breast radiotherapy for invasive breast cancer

Liau

Cariati²,

Noble

et al. 2010

annals

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INTRODUCTION The risk of ipsilateral breast tumour recurrence (IBTR) following breast conservation surgery (BCS) for invasive breast cancer (IBC) and radiotherapy is dependent on patient-, tumour-and treatment-related variables. In the Cambridge Breast Unit, breast conserving surgery has been performed with a target radial margin of 5 mm for IBC, in combination with 40-Gy hypofractionated (15 fractions) breast radiotherapy, since 1999. PATIENTS AND METHODS An audit was performed of cases treated between 1999 and 2004. A total of 563 patients underwent BCS for invasive breast cancer with 90.4% receiving radiotherapy (RT) and 60.4% of patients receiving boost RT (3 fractions of 3-Gy). RESULTS After a median follow-up of 58 months, five of the 563 (0.9%) patients developed IBTR. The 5-year actuarial IBTR rate was 1.1%. In terms of distant disease recurrence (DDR), 29 of the 563 (5.2%) had DDR during follow-up, giving a 5-year actuarial DDR rate of 5.4%. The 5-year breast cancer specific survival was 95%, with the poorer NPI groups having worse breast cancer specific survival (Log-rank, P < 0.0001). More importantly, patients with IBTR had a shorter breast cancer-specific survival than those who were IBTR-free (Log-rank, P < 0.0001). CONCLUSIONS Our treatment regimen, combining BCS with a 5-mm target margin and hypofractionated 40-Gy RT, results in an extremely low rate of IBTR, and compares favourably with the target IBTR rate of < 5% defined by the Association of Breast Surgeons (ABS) at BASO guidelines.

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mentioning

confidence: 99%

Audit of local recurrence following breast conservation surgery with 5-mm target margin and hypofractionated 40-Gray breast radiotherapy for invasive breast cancer

Liau

Cariati²,

Noble

et al. 2010

annals

View full text Add to dashboard Cite

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2001 Longterm follow-up of axillary node positive breast cancer patients receiving adjuvant systemic therapy alone: Patterns of recurrence

Cited by 1 publication

References 0 publications

Audit of local recurrence following breast conservation surgery with 5-mm target margin and hypofractionated 40-Gray breast radiotherapy for invasive breast cancer

Audit of local recurrence following breast conservation surgery with 5-mm target margin and hypofractionated 40-Gray breast radiotherapy for invasive breast cancer

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