200 mm wafer-scale integration of sub-20 nm sacrificial nanofluidic channels for manipulating and imaging single DNA molecules

Wang, C.; Nam, Sung Wook; Cotte, J.; Peng, Hongbo; Jahnes, C.; Wang, D.; Bruce, Robert L.; Guillorn, Michael A.; Gignac, Lynne; Advocate, W. H.; Breslin, Chris; Brink, Markus; Bucchignano, J.; Duch, Elizabeth A.; Galan, Armand; Kratschmer, E.; Litwinowicz, P. J.; Lofaro, M.; Price, W. H.; Rossnagel, S. M.; Goldblatt, R.; Joseph, Eric; Pfeiffer, Douglas R.; Rao, Satyavolu S. Papa; Royyuru, A. K.; Stolovitzky, Gustavo; Colgan, E. G.; Lin, Qinghuang; Polonsky, S.

doi:10.1109/iedm.2013.6724627

Cited by 2 publications

(2 citation statements)

References 5 publications

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“…Molecules were stretched prior to imaging via gradient nanopillars, which were located in the channels. The IBM team claims that their easy to manufacture design and reproducible techniques (illustrated in Figure ) have a variety of potential applications . This work closely follows that of Rommel's team in 2012, who used the synthetic interference lithography/ion etching technique in an effort to develop a low‐cost, simplistic fabrication method .…”

Section: Micro‐ To Nanofluidics An Introductionmentioning

confidence: 83%

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Pioneering medical advances through nanofluidic implantable technologies

Hood

Ferrari

et al. 2017

WIREs Nanomed Nanobiotechnol

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Nanofluidic implantables represent a recent advance in a broad effort for developing personalized, point-of-care medical technologies. Such systems have unprecedented potential when matched with the newest developments in robotics, microprocessing, and tissue engineering. In this review, we present their emergence in medicine within the fields of diagnostics, biosensing, therapeutics, and theranostics. Discussion includes current limitations and future directions for these systems, as commensurate advances in power density and electronic processing are continually redefining the possible. As the research and funding attention coincide with complementary technological breakthroughs, the field is expected to grow into an advanced toolset for preserving human health. WIREs Nanomed Nanobiotechnol 2017, 9:e1455. doi: 10.1002/wnan.1455.

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Section: Micro‐ To Nanofluidics An Introductionmentioning

confidence: 83%

“…One to three show the microchannel, nanochannel, and vent‐hole modules, respectively. (Figure (a), Reprinted with permission from Ref . Copyright 2013 IBM ) (b) A transmission electron microscope (TEM) image of a sacrificially etched nanochannel with a 5 nm characteristic dimension.…”

Section: Micro‐ To Nanofluidics An Introductionmentioning

confidence: 99%

Pioneering medical advances through nanofluidic implantable technologies

Hood

Ferrari

et al. 2017

WIREs Nanomed Nanobiotechnol

View full text Add to dashboard Cite

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Creation of a transient vapor nanogap between two fluidic reservoirs for single molecule manipulation

Polonsky¹,

Balagurusamy²,

Ott³

2014

Review of Scientific Instruments

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We introduce a new experimental technique for manipulating a segment of a charged macromolecule inside a transient nanogap between two fluidic reservoirs. This technique uses an FPGA-driven nanopositioner to control the coupling of a nanopipette with the liquid surface of a fluidic cell. We present results on creating a transient nanogap, triggered by a translocation of double-stranded DNA between a nanopipette and a fluidic cell, and measure the probability to find the molecule near the tip of the nanopipette after closing the gap. The developed platform will enable testing of our recent theoretical predictions for the behavior of charged macromolecule in a nanogap between two fluidic reservoirs.

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200 mm wafer-scale integration of sub-20 nm sacrificial nanofluidic channels for manipulating and imaging single DNA molecules

Cited by 2 publications

References 5 publications

Pioneering medical advances through nanofluidic implantable technologies

Pioneering medical advances through nanofluidic implantable technologies

Creation of a transient vapor nanogap between two fluidic reservoirs for single molecule manipulation

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