2-Amino-3′-dialkylaminobiphenyl-based fluorescent intracellular probes for nitric oxide surrogate N₂O₃

Abstract

A thorough structure-property relationship study has produced much-improved fluorescence probes for nitric oxide surrogate, e.g. N2O3, compared to the original NO550.

Small-molecule fluorescent probes based on covalent assembly strategy for chemoselective bioimaging

“…18B ). 109 Among the probes, NO7 acts as a promising material for live cell imaging. Due to its greater response to stimuli, higher selectivity for NO, and the ability to image both the reacted and unreacted probe, NO7 provides an attractive option as a nitric oxide probe and a potentially valuable alternative to the commercial dye DAF-FM in various applications.…”

Nitric Oxide Releasing Delivery Platforms: Design, Detection, Biomedical Applications, and Future Possibilities

“…After triazole formation, the quenching process is hindered, which leads to fluorescence enhancement. 30 Kojima and co-workers first reported DAFs probes that have a detection limit up to 5 nM of NO. 31 These probes exhibit fluorescence increments of ∼100 folds after the triazole formation, and they can be excited with visible wavelength light.…”

Development of a ratiometric nitric oxide probe with baseline resolved emissions by an ESIPT and rhodol ring opened-closed integrated two-photon platform

“…As an important free radical in living organisms and an indispensable messenger molecule in pathological processes such as heart disease, immune system disease, and neurological degeneration disease, nitric oxide (NO) is produced from Larginine under the action of nitric oxide synthase. [1][2][3][4][5] Revealing the distribution and concentration uctuations of NO is essential for the early diagnosis of the above-mentioned diseases. [6][7][8][9][10] Currently, uorescence imaging has provided powerful assistance for real-time and in situ detection of NO distribution and concentration uctuations in living organisms due to its advantages of simple operation, visualization, high sensitivity, and high spatial and temporal resolution.…”