1TP3-06 Effects of Pressure on Volume-Fluctuation Dynamics of Proteins(The 47th Annual Meeting of the Biophysical Society of Japan)

Abstract

Polyglutamme digcases which melude Huntmgton s disease are Laused by an abnormal expansion of CAG repeats If the numbei of the repeat lcngth becomes longei than the LmuLat length the protein would miglold and aggregate to form inseluble amyToid like fibritts eve"tually leading to ncuronal dygfunction and cell death lt is ktiown that polyg!utamme peptides take the S ghcet structure when they aggregate but theil detal]ed structure s still unclear Recent studies hdve indiLatLd that monomtllc polygluLamme peptide has no specifie stiucture We theTetore performed the replica exchange moleLular dynamics (REMD) simulation te investigate the conformauon ensernble of menomenL