18F-FDG whole body positron emission tomography (PET) in patients with unknown primary tumours (UPT)

Lassen, Ulrik; Daugaard, Gedske; Eigtved, Annika; Damgaard, Karen; Friberg, Lars

doi:10.1016/s0959-8049(99)00077-5

Cited by 123 publications

(72 citation statements)

References 14 publications

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“…According to the literature, carcinoma of the lung and pancreas are the most common primary carcinomas that initially present as CUP (15,16). Other common malignancies such as colorectal, breast, and prostate cancer infrequently present as CUP (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…Other common malignancies such as colorectal, breast, and prostate cancer infrequently present as CUP (15,16). The anatomic location, size, and number of the lesions (inadequate viable liver tissue that could remain after operation), or patient's comorbid conditions (i.e., cardiac, pulmonary, or renal failure), each one alone or in combination, makes operation unsafe or impossible (17).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Radiofrequency ablation of liver metastases from cancer of unknown primary site (cup)

Mylona

Stroumpouli²,

Pomoni³

et al. 2009

Diagn Interv Radiol

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Radiofrequency ablation of liver metastases from cancer of unknown primary site (cup)

Mylona

Stroumpouli²,

Pomoni³

et al. 2009

Diagn Interv Radiol

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“…Recent series have reported the utility of PET imaging in patients specifically with cervical lymph node presentations [16][17][18][19][20][21][22] as well as in other sites [23][24][25][26]. Those studies indicate that PET imaging can detect an unknown primary tumor in 20%-60% of patients when conventional workups have failed to do so.…”

Section: Pet Scanning In Unknown Primary Cancer Gary Greene MDmentioning

confidence: 99%

Cancer of Unknown Primary: Changing Approaches. A Multidisciplinary Case Presentation from the Joan Karnell Cancer Center of Pennsylvania Hospital

et al. 2004

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Cancer of unknown primary is a common clinical syndrome, accounting for 2%-5% of cancer patients. A representative case is presented. This heterogenous group of disorders includes entities such as poorly differentiated carcinoma of unknown primary, adenocarcinoma of unknown primary, neuroendocrine carcinoma of unknown primary, squamous cell carcinoma of unknown primary, poorly differentiated (not otherwise specified) cancer of unknown primary, and melanoma of unknown primary. It is crucial to identify those treatment-responsive presentations of unknown primary with the greatest potential for long-term survival.This discussion emphasizes newer approaches to the diagnosis and treatment of unknown primary cancer, including advances in pathology with immunoperoxidase and molecular genetic techniques, positron emission tomography, and published chemotherapeutic trials. With the increased sophistication of pathologic and radiologic techniques, the frequency of unknown primary cancers will likely continue to decline. Further, as newer and more targeted therapies for specific types of cancer are identified, the previously held nihilism regarding the search for and identification of the primary may become less supportable. The Oncologist 2004;9:330-338 The Oncologist 2004;9:330-338 www.TheOncologist.com Correspondence: David M. Mintzer, M.D., Joan Karnell Cancer Center, 230 West Washington Square, 2nd Floor, Philadelphia, Pennsylvania 19106, USA. Telephone: 215-829-6088; Fax: 215-829-6104; e-mail: dmmonc@aol.com Received September 5, 2003; accepted for publication December 16, 2003. ©AlphaMed Press 1083-7159/2004 CASE PRESENTATIONA 49-year-old female presented with swollen lymph nodes in her left neck. She felt well without any active systemic or localizing symptoms. She had a history of an early cervical cancer treated 15 years previously with cryosurgery and cone resection without known recurrence. TheOncologist ® Cancer Medicine: Case Discussion LEARNING OBJECTIVESAfter completing this course, the reader will be able to:1. Describe the newer pathologic techniques for defining the site of origin of unknown primary cancers, including immunohistochemistry and molecular genetic techniques.2. List the subsets of patients with unknown primary cancers most likely to achieve long-term survival with appropriate therapies.3. Explain how the newer radiologic techniques such as MRI and PET scanning can help to localize unknown primary cancers.Access and take the CME test online and receive 1 hour of AMA PRA category 1 credit at CME.TheOncologist.com CME CMEThis material is protected by U.S. Copyright law. Unauthorized reproduction is prohibited. For reprints contact: Reprints@AlphaMedPress.com Mintzer, Warhol, Martin et al. 331 She had undergone a benign right breast biopsy 3 years previously. Her past medical history was notable for mitral valve prolapse, tonsillectomy, and appendectomy. She had quit smoking 6 years previously, with a 15 pack-year history. Her family history was positive for colon cancer in he...

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“…The rate of primary tumour detection by FDG-PET/CT found in our study is in agreement with most studies in literature, with site detection rates of between 21% and 47%. 13,14,15,16,17,18 The low rate of detection of primary in CUPS, by imaging modalities employed so far, attributed to various factor; spontaneous regression, immune modulated destruction of the primary cancer , faster proliferation rate of lymphnodal metastases .and removal of primary site by sloughing of a necrotic tumour from the gastrointestinal tract are discussed . Bronchogenic carcinoma mistaken for a lymph node metastasis may also be an explanation for an unsuccessful primary tumour search.…”

mentioning

confidence: 99%

“…Various other studies mentioned a wide range of false positive result (7 to 31 %). 14,15,16,17,18,19 These false positive result could be due to a few factors like a high physiological uptake in head and neck region and GIT. The small size of the tumour has also been attributed to missing the lesion on biopsy, wherein a sampling error, could lead to apparent false positive FDG -PET results.…”

mentioning

confidence: 99%

Role of F-18 FDG PET/CT to Identify Potential Primary Lesion in Carcinoma of Unknown Primary Site (CUPS)

Agarwal¹

2017

jmscr

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18F-FDG whole body positron emission tomography (PET) in patients with unknown primary tumours (UPT)

Cited by 123 publications

References 14 publications

Radiofrequency ablation of liver metastases from cancer of unknown primary site (cup)

Radiofrequency ablation of liver metastases from cancer of unknown primary site (cup)

Cancer of Unknown Primary: Changing Approaches. A Multidisciplinary Case Presentation from the Joan Karnell Cancer Center of Pennsylvania Hospital

Role of F-18 FDG PET/CT to Identify Potential Primary Lesion in Carcinoma of Unknown Primary Site (CUPS)

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