2005
DOI: 10.1593/neo.04577
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Abstract: Our study indicates that 18F-FDG uptake in lung cancer correlates well with the Glut-1, HK-II, and PCNA expression. For nonmalignant lesions, the presence of a higher inflammatory process correlated with 18F-FDG uptake.

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Cited by 208 publications
(161 citation statements)
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“…In adenocarcinoma, poorly differentiated areas such as the solid central area were stained more strongly than well differentiated areas such as those showing lepidic growth. [20][21][22]24 In the present study, more than half of all tumor cells were positive for GLUT-1 in 37.5% of MPMs, 85.7% of lung squamous cell carcinomas, and 36.7% of lung adenocarcinomas. These results indicate that GLUT-1 negativity in small samples such as those obtained by biopsy does not exclude malignancy, and that positive immunoreactivity for GLUT-1 may be an aid to accurate diagnosis of malignancy.…”
Section: Discussionmentioning
confidence: 68%
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“…In adenocarcinoma, poorly differentiated areas such as the solid central area were stained more strongly than well differentiated areas such as those showing lepidic growth. [20][21][22]24 In the present study, more than half of all tumor cells were positive for GLUT-1 in 37.5% of MPMs, 85.7% of lung squamous cell carcinomas, and 36.7% of lung adenocarcinomas. These results indicate that GLUT-1 negativity in small samples such as those obtained by biopsy does not exclude malignancy, and that positive immunoreactivity for GLUT-1 may be an aid to accurate diagnosis of malignancy.…”
Section: Discussionmentioning
confidence: 68%
“…35 GLUT-1 expression has been revealed in a variety of carcinomas, such as those of the breast, head and neck, bladder, and renal cells. [15][16][17][18][19]23 In the lung, about 34.3-100% of lung adenocarcinomas 16,[20][21][22]24 and 100% of lung squamous cell carcinomas [20][21][22]24 are reported to express GLUT-1 at the primary site. With regard to MPM, only one article has describe that two of four studied cases were positive for GLUT-1.…”
Section: Discussionmentioning
confidence: 99%
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“…Moreover, the expression of glucose transporter type 1 (Glut-1) differed substantially between NSCLC of different histologies [23]. Adenocarcinomas were reported to express low levels of Glut-1 [24]. These tumours have a lower 18FDG uptake and a lower SUVmax than squamous cell tumours [21].…”
Section: Discussionmentioning
confidence: 99%
“…However, although Glut-1 is the major glucose transporter expressed in NSCLC, it is neither the sole nor the rate-limiting determinant of FDG uptake [25]. FDG uptake is known to be related to hexokinase and glucose-6-phosphatase activities in cancer [24,25]. Moreover, at the whole tumour level, FDG depends on such factors as tumour blood flow, intratumoral microvessel density and viable tumour cell number [2].…”
Section: Discussionmentioning
confidence: 99%