18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma

Lee, Jeong Won; Kang, Keon Wook; Park, Shin Young; Lee, Sang Mi; Paeng, Jin Chul; Chung, June Key; Lee, Myung Chul; Lee, Dong Hoon

doi:10.1007/s00259-009-1133-x

Cited by 73 publications

(50 citation statements)

References 24 publications

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“…Tumor volume was significant for model construction (P \ 0.0001) whereas tumor location was not (P = 0.793) biological aggressiveness of the tumor [13,15], whereas other reports have failed to reproduce such observations [24]. One report pointed out that 18 F-FDG PET has low sensitivity in discriminating high-grade meningiomas from low-grade, although significant differences in 18 F-FDG uptake between high and low-grade meningiomas are observed at the same time [6]. The potential of 18 F-FDG PET for predicting tumor proliferative potential or histological grading is controversial for meningiomas.…”

Section: Discussionmentioning

confidence: 78%

“…Development of such methods would enable diagnosis of malignant meningiomas without performing surgical resection and would benefit patients harboring such tumors. However, few reports have referred to the possibility of using metabolic imaging to characterize meningiomas [6,[11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 98%

“…Although the risk factors for malignant behavior of meningiomas are not fully understood, factors such as tumor location and shape have been implicated [4,5]. However, biological aggressiveness and histopathological grading can currently only be assessed after surgical removal of the tumor [6].…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography

et al. 2011

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The clinical course of meningioma varies from case to case, despite similar characteristics on magnetic resonance (MR) imaging. Functional imaging including (11)C-methionine and (18)F-fluorodeoxyglucose (FDG) positron-emission tomography (PET) has been widely studied for noninvasive preoperative evaluation of brain tumors. However, few reports have examined correlations between meningiomas and findings on (11)C-methionine and FDG PET. The objective of this study was to clarify the relationship between tumor characteristics and (11)C-methionine and FDG uptake in meningiomas. For 68 meningiomas in 51 cases, (11)C-methionine uptake was evaluated by measuring both mean and maximum tumor/normal (T/N) ratio for the whole area of the tumors. FDG uptake in 44 of those meningiomas was also analyzed. Tumor size was measured volumetrically, and tumor-doubling time was estimated. Histopathological evaluation was performed in 19 surgical cases. Mean and maximum T/N ratios of (11)C-methionine PET were significantly higher in skull-base lesions than in non-skull-base lesions. Correlations of mean and maximum T/N ratio of (11)C-methionine PET with tumor-doubling time, MIB-1 labeling index, microvessel density and World Health Organization grading were not significant. Mean T/N ratio of (11)C-methionine PET correlated significantly with tumor volume according to logarithm regression modeling (P < 0.0001, R = 0.544). However, mean and maximum T/N ratio of FDG-PET correlated with none of the tumor characteristics described above. These results suggest that (11)C-methionine uptake correlates with tumor volume, but not with tumor aggressiveness.

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Section: Discussionmentioning

confidence: 78%

Section: Introductionmentioning

confidence: 98%

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Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography

et al. 2011

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“…[5][6][7] However, the sensitivity of FDG PET to detect high-grade meningioma was not high. 8 One important finding in this patient was the leukemoid reaction as a presenting sign. Paraneoplastic leukemoid reaction is a sign of a poor prognosis in solid tumors and has often been described in many other malignancies.…”

Section: Figurementioning

confidence: 97%

MRI and FDG PET/CT Uncovered the Cause of a Paraneoplastic Leukemoid Reaction

Wang

Han

Chen

2016

Clinical Nuclear Medicine

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An 18-year-old man with progressive headache and vomiting for 2 weeks had significantly elevated levels of WBC count, which kept on rising over time during in-hospital evaluation. Exhaustive examinations did not reveal infection or any other explanations of increased WBC count. Instead, brain MRI and FDG PET/CT identified a malignant lesion in the brain without abnormality elsewhere. The pathological examination revealed a rhabdoid meningioma. The level of the WBC counts returned to normal promptly after surgical resection of the tumor, which confirmed the diagnosis of paraneoplastic leukemoid reaction.

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“…Lee et al recently reported that FDG uptake using PET scans was higher in Grade II and III meningiomas as compared with Grade I lesions and was predictive of tumor recurrence and aggressiveness [6]. However, the utility of this observation in clinical practice is still unclear.…”

Section: Diagnosismentioning

confidence: 97%

Management of Meningeal Neoplasms: Meningiomas and Hemangiopericytomas

Lamar

Lesser

2011

Curr. Treat. Options in Oncol.

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Meningiomas are the most frequently diagnosed primary brain tumor accounting for nearly one third of all primary brain and central nervous system tumors reported in the United States. According to the 2007 World Health Organization classification scheme, Grade I meningiomas are benign, Grade II defines atypical lesions, while Grade III meningiomas are anaplastic or frankly malignant tumors. Not surprisingly, Grade II and III meningiomas usually follow a more aggressive course and confer a worse prognosis. The diagnosis of meningioma is confirmed by pathologic examination and improvements in imaging help to better define when observation versus intervention is appropriate. Surgical resection, when possible, is the mainstay of treatment. When complete resection is not possible, stereotactic radiosurgery (SRS) can result in disease stabilization. Chemotherapy has yet to result in reproducible long-term disease free or overall survival benefits. Biologic agents remain under investigation. Hemangiopericytomas are rare dural based sarcomas. These tumors are known for their aggressiveness, high recurrence rates and their proclivity to metastasize to extracranial locations. Gross total resection when feasible remains the treatment of choice.

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18F-FDG PET in the assessment of tumor grade and prediction of tumor recurrence in intracranial meningioma

Abstract: FDG uptake in meningioma was the significant predictive factor of tumor recurrence and significantly correlated with the proliferative potential of the tumor.

Cited by 73 publications

References 24 publications

Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography

Clinical characteristics of meningiomas assessed by 11C-methionine and 18F-fluorodeoxyglucose positron-emission tomography

MRI and FDG PET/CT Uncovered the Cause of a Paraneoplastic Leukemoid Reaction

Management of Meningeal Neoplasms: Meningiomas and Hemangiopericytomas

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