18F-FDG PET/CT and COVID-19

Joob, Beuy; Wiwanitkit, Viroj

doi:10.1007/s00259-020-04762-6

Cited by 34 publications

(28 citation statements)

References 3 publications

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“…For these patients, isolation and medical treatment should be carried out as early as possible, which would be helpful for better control of the infection and cut off the transmission at an early stage. Moreover, this study's first-time nucleic acid RT-PCR tests have a test positive rate of 68%, which is higher than previous study (14,16) (positive rate 30-50%). It may be related to the fact that the nucleic acid test samples were collected and stored by specialized personnel in our hospital who had received professional training.…”

Section: Threshold Diagnostic Value Of Patient Age and Lymphocyte Countcontrasting

confidence: 69%

“…Previous research (14) shows the main reasons of nucleic acid RT-PCR test's false negative lymphocyte count lower than 1.53×10 9 /L should be considered linked to COVID-19. If there is available travel history in epidemic area or contact history with people form epidemic area or with confirmed patients, that could provide another strong evidence for diagnosing COVID-19.…”

Section: Threshold Diagnostic Value Of Patient Age and Lymphocyte Countmentioning

confidence: 99%

“…At present, real-time reverse transcriptase polymerase chain reaction (RT-PCR) is used as main method of virus infection detection (13). Many studies had shown that the positive rate of RT-PCR could be low, especially the first time of nucleic acid test (12,14). How to increase the effectiveness of COVID-19 early diagnosis when RT-PCR has high false negative rate is the major challenge during the combat against SARS-CoV-2 around world.…”

Section: Introductionmentioning

confidence: 99%

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Analysis of factors associated early diagnosis in coronavirus disease 2019 (COVID-19)

Gong

Xing

et al. 2020

Preprint

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Background The pandemic of coronavirus disease 2019 (COVID-19) has become the first concern in international affairs as the novel coronavirus (SARS-CoV-2) is spreading all over the world at a terrific speed. The accuracy of early diagnosis is critical in the control of the spread of the virus. Although the real-time RT-PCR detection of the virus nucleic acid is the current golden diagnostic standard, it has high false negative rate when only apply single test. Objective Summarize the baseline characteristics and laboratory examination results of hospitalized COVID-19 patients. Analyze the factors that could interfere with the early diagnosis quantitatively to support the timely confirmation of the disease. Methods All suspected patients with COVID-19 were included in our study until Feb 9th, 2020. The last day of follow-up was Mar 20th, 2020. Throat swab real-time RT-PCR test was used to confirm SARS-CoV-2 infection. The difference between the epidemiological profile and first laboratory examination results of COVID-19 patients and non-COVID-19 patients were compared and analyzed by multiple logistic regression. Receiver operating characteristic (ROC) curve and area under curve (AUC) were used to assess the potential diagnostic value in factors, which had statistical differences in regression analysis. Results In total, 315 hospitalized patients were included. Among them, 108 were confirmed as COVID-19 patients and 207 were non-COVID-19 patients. Two groups of patients have significance in comparing age, contact history, leukocyte count, lymphocyte count, C-reactive protein, erythrocyte sedimentation rate (p<0.10). Multiple logistic regression analysis showed age, contact history and decreasing lymphocyte count could be used as individual factor that has diagnostic value (p<0.05). The AUC of first RT-PCR test was 0.84 (95% CI 0.73-0.89), AUC of cumulative two times of RT-PCR tests was 0.92 (95% CI 0.88-0.96) and 0.96 (95% CI 0.93-0.99) for cumulative three times of RT-PCR tests. Ninety-six patients showed typical pneumonia radiological features in first CT scan, AUC was 0.74 (95% CI 0.60-0.73). The AUC of patients age, contact history with confirmed people and the decreased lymphocytes were 0.66 (95% CI 0.60-0.73), 0.67 (95% CI 0.61-0.73), 0.62 (95% CI 0.56-0.69), respectively. Taking chest CT scan diagnosis together with patients age and decreasing lymphocytes, AUC would be 0.86 (95% CI 0.82-0.90). The age threshold to predict COVID-19 was 41.5 years, with a diagnostic sensitivity of 0.70 (95% CI 0.61-0.79) and a specificity of 0.59 (95% CI 0.52-0.66). Positive and negative likelihood ratios were 1.71 and 0.50, respectively. Threshold of lymphocyte count to diagnose COVID-19 was 1.53x109/L, with a diagnostic sensitivity of 0.82 (95% CI 0.73-0.88) and a specificity of 0.50 (95% CI 0.43-0.57). Positive and negative likelihood ratios were 1.64 and 0.37, respectively. Conclusion Single RT-PCR test has relatively high false negative rate. When first RT-PCR test show negative result in suspected patients, the chest CT scan, contact history, age and lymphocyte count should be used combinedly to assess the possibility of SARS-CoV-2 infection.

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Section: Threshold Diagnostic Value Of Patient Age and Lymphocyte Countcontrasting

confidence: 69%

Section: Threshold Diagnostic Value Of Patient Age and Lymphocyte Countmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Analysis of factors associated early diagnosis in coronavirus disease 2019 (COVID-19)

Gong

Xing

et al. 2020

Preprint

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“…More broadly, Deng et al [3] also argue for the possible 18 F-FDG PET utility, as a sensitive tool to detect and monitor inflammatory diseases, such as viral pneumonia, monitor disease progression, and treatment outcomes, according to the major goals of precision medicine in which PET imaging is well-known to be crucially involved [4]. On the opposite, Joob and Wiwanitkit have recalled that 18 F-FDG PET is still not recommended in infectious pneumonia, and especially warned of the risk of disease spreading in PET departments [5].…”

mentioning

confidence: 99%

PET imaging of COVID-19: the target and the number

Guedj

Verger

Cammilleri

2020

Eur J Nucl Med Mol Imaging

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“…In contrast, another letter to the editor by Joob et al [47], had a different view, staging that 18 F-FDG PET/CT is a more complex test than chest CT, and longer testing period for 18 F-FDG PET/CT examinations may increase risk of disease transmission. They conclude that further studies are needed to determine whether 18 F-FDG PET/CT is an appropriate testing modality for COVID-19, and this is currently not recommended for COVID-19 diagnosis.…”

Section: ) Pet/ctmentioning

confidence: 99%

The Role of Imaging in the Detection and Management of COVID-19: A Review

Dong

Tang

Wang

et al. 2021

IEEE Rev. Biomed. Eng.

341

247

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Coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is spreading rapidly around the world, resulting in a massive death toll. Lung infection or pneumonia is the common complication of COVID-19, and imaging techniques, especially computed tomography (CT), have played an important role in diagnoses and treatment assessment of the disease. Herein, we review the use of imaging characteristics and computing models that have been applied for the management of COVID-19. CT, positron emission tomography -CT (PET/CT), lung ultrasound, and magnetic resonance imaging (MRI) have been used for detection, treatment, and follow-up. The quantitative analysis of imaging data using artificial intelligence (AI) is also explored. Our findings indicate that typical imaging characteristics and their changes can play an important role in the detection and management of COVID-19. In addition, AI or other quantitative image analysis methods are urgently needed to maximize the value of imaging in the management of COVID-19.

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18F-FDG PET/CT and COVID-19

Cited by 34 publications

References 3 publications

Analysis of factors associated early diagnosis in coronavirus disease 2019 (COVID-19)

Analysis of factors associated early diagnosis in coronavirus disease 2019 (COVID-19)

PET imaging of COVID-19: the target and the number

The Role of Imaging in the Detection and Management of COVID-19: A Review

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