2010
DOI: 10.1055/s-0030-1249945 View full text |Buy / Rent full text
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Abstract: Our study shows that 18F-FDG PET/CT improves the identification and characterisation of potentially malignant pulmonary nodules with a diameter < 1 cm. This technique could be a valid alternative to a surgical approach, currently the main method to investigate indeterminate lung nodules.

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“…although evidence from a few small studies is decidedly mixed, [127][128][129] consensus holds that they are not reliably characterized by PET scan. Given the relatively low prevalence of malignancy, the risks of surgical diagnosis usually outweigh the benefits.…”
Section: 31mentioning
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“…although evidence from a few small studies is decidedly mixed, [127][128][129] consensus holds that they are not reliably characterized by PET scan. Given the relatively low prevalence of malignancy, the risks of surgical diagnosis usually outweigh the benefits.…”
Section: 31mentioning
“…These authors described a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96%, 76%, 86%, and 93% respectively. In our experience, 8 which includes 57 patients with lesions of between 5 mm and 9 mm, the 18 F-FDG PET showed a sensitivity, specificity and accuracy of 95%, 72%, and 82% respectively. The fibrobronchoscopy, 9 the endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB/TBNA), 10 the CT led percutaneous pulmonary biopsy (CTPLB) 11,12 and videoassisted thoracic surgery (VATS) 13 for peripheral SPNs made it possible to obtain a preoperative histological diagnosis and to establish procedures for surgery.…”
Section: Introductionmentioning
“…[10] Although there are limited number of comparative studies on the diagnostic performance of CT versus PET/CT in SPNs, one of the studies has shown that 18 F-FDG PET/CT is superior to CT alone in nodules smaller than 1.5 cm, proving that it is the most optimal diagnostic method in characterization of small nodules. [10] In our study, there were seven patients with SPNs smaller than 1.5 cm which had a SUV max value above 2.5 in three (who had negative follow-up results in one, tuberculosis in one, and adenocarcinoma in one) and below 2.5 in four patients (which confirmed to be tuberculosis in one and who had negative results in three). In another study, the diagnostic efficacy of FDG PET/CT and quantitative first-pass 320 detector row perfusion CT were compared in discrimination of malignant and benign pulmonary nodules and concluded that CT had potential to be more specific and accurate.…”
Section: Discussionmentioning
“…[9] As a result, the reduction in the number of unnecessary thoracotomies has been achieved by imaging of the SPNs with PET/CT. [10] However, false positive results are one of the major disadvantages of PET/CT imaging particularly in countries with a higher incidence of granulomatous diseases. [11] Another disadvantage of this imaging method is false negative results related to some specific histopathological subtypes, particularly to adenocarcinomas.…”
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