18-Fluorine Fluorodeoxyglucose Positron Emission Tomography with Computerized Tomography Versus Computerized Tomography Alone for the Management of Solitary Lung Nodules with Diameters Inferior to 1.5 cm

Divisi, Duilio; Tommaso, Sergio Di; Leonardo, Gabriella Di; Brianzoni, E; Vico, Andrea De; Crisci, Roberto

doi:10.1055/s-0030-1249945

Cited by 38 publications

(28 citation statements)

References 16 publications

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“…although evidence from a few small studies is decidedly mixed, [127][128][129] consensus holds that they are not reliably characterized by PET scan. Given the relatively low prevalence of malignancy, the risks of surgical diagnosis usually outweigh the benefits.…”

Section: 31mentioning

confidence: 99%

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Gould

Donington

Lynch

et al. 2013

Chest

1,072

1,022

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we suggest that no additional diagnostic evaluation need be performed (Grade 2C) .Remark : This recommendation applies only to solid nodules. For guidance about follow-up of subsolid nodules, see Recommendations 6.5.1 to 6.5.4 . 2.3.3.In the individual with an indeterminate nodule that is identifi ed by chest radiography, we recommend that CT of the chest should be performed (preferably with thin sections Objectives: The objective of this article is to update previous evidence-based recommendations for evaluation and management of individuals with solid pulmonary nodules and to generate new recommendations for those with nonsolid nodules. Methods: We updated prior literature reviews, synthesized evidence, and formulated recommendations by using the methods described in the "Methodology for Development of Guidelines for Lung Cancer" in the American College of Chest Physicians Lung Cancer Guidelines, 3rd ed. Results: We formulated recommendations for evaluating solid pulmonary nodules that measure . 8 mm in diameter, solid nodules that measure Յ 8 mm in diameter, and subsolid nodules. The recommendations stress the value of assessing the probability of malignancy, the utility of imaging tests, the need to weigh the benefi ts and harms of different management strategies (nonsurgical biopsy, surgical resection, and surveillance with chest CT imaging), and the importance of eliciting patient preferences. Conclusions: Individuals with pulmonary nodules should be evaluated and managed by estimating the probability of malignancy, performing imaging tests to better characterize the lesions, evaluating the risks associated with various management alternatives, and eliciting their preferences for management. CHEST 2013; 143(5)(Suppl):e93S-e120SAbbreviations: AAH 5 atypical adenomatous hyperplasia; ACCP 5 American College of Chest Physicians; AIS 5 adenocarcinoma in situ; EBUS 5 endobronchial ultrasound; ENB 5 electromagnetic navigation bronchoscopy; FDG 5 fl uorodeoxyglucose; HU 5 Hounsfi eld unit; LR 5 likelihood ratio; SPECT 5 single-photon emission CT; TBB 5 transbronchial biopsy; TTNB 5 transthoracic needle biopsy; VATS 5 video-assisted thoracic surgery; VBN 5 virtual bronchoscopy navigation; VDT 5 volume doubling time

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Section: 31mentioning

confidence: 99%

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Gould

Donington

Lynch

et al. 2013

Chest

1,072

1,022

View full text Add to dashboard Cite

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“…These authors described a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 96%, 76%, 86%, and 93% respectively. In our experience, 8 which includes 57 patients with lesions of between 5 mm and 9 mm, the 18 F-FDG PET showed a sensitivity, specificity and accuracy of 95%, 72%, and 82% respectively. The fibrobronchoscopy, 9 the endobronchial ultrasound-guided transbronchial biopsy (EBUS-TBB/TBNA), 10 the CT led percutaneous pulmonary biopsy (CTPLB) 11,12 and videoassisted thoracic surgery (VATS) 13 for peripheral SPNs made it possible to obtain a preoperative histological diagnosis and to establish procedures for surgery.…”

Section: Introductionmentioning

confidence: 80%

Clinical Management of Solitary Pulmonary Micronodule: A Pilot Study

Crisci

Divisi

2013

Archivos de Bronconeumología (English Edition)

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“…[10] Although there are limited number of comparative studies on the diagnostic performance of CT versus PET/CT in SPNs, one of the studies has shown that 18 F-FDG PET/CT is superior to CT alone in nodules smaller than 1.5 cm, proving that it is the most optimal diagnostic method in characterization of small nodules. [10] In our study, there were seven patients with SPNs smaller than 1.5 cm which had a SUV max value above 2.5 in three (who had negative follow-up results in one, tuberculosis in one, and adenocarcinoma in one) and below 2.5 in four patients (which confirmed to be tuberculosis in one and who had negative results in three). In another study, the diagnostic efficacy of FDG PET/CT and quantitative first-pass 320 detector row perfusion CT were compared in discrimination of malignant and benign pulmonary nodules and concluded that CT had potential to be more specific and accurate.…”

Section: Discussionmentioning

confidence: 99%

“…[9] As a result, the reduction in the number of unnecessary thoracotomies has been achieved by imaging of the SPNs with PET/CT. [10] However, false positive results are one of the major disadvantages of PET/CT imaging particularly in countries with a higher incidence of granulomatous diseases. [11] Another disadvantage of this imaging method is false negative results related to some specific histopathological subtypes, particularly to adenocarcinomas.…”

mentioning

confidence: 99%

Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers

Karyağar¹

2017

Turk Gogus Kalp Dama

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ÖZAmaç: Bu çalışmada, sigara içme öyküsü olmayan soliter pulmoner nodüllü hastalarda flor-18 florodeoksiglikoz pozitron emisyon tomografi/bilgisayarlı tomografinin ( 18 F-FDG PET/BT) tanısal gücü araştırıldı.Ça lış mapla nı:Haziran 2009 -Mart 2013 tarihleri arasında, sigara içme öyküsü olmayan, soliter pulmoner nodüllü olan, 18 F-FDG PET/BT görüntülemesi yapılan toplam 38 hasta (25 kadın, 13 erkek; ort. yaş 63±14 yıl; dağılım 23-84 yıl) retrospektif olarak incelendi. Her hastanın tıbbi öyküsü alındı ve malignite tanısı tüm hastalarda ilk olarak bilgisayarlı tomografi ile kondu. Tanı, daha sonra histopatolojik analiz sonuçları veya en az iki yıllık takip sonuçları ile doğrulandı. Bul gu lar:Ortalama lezyon çapı 20±6 (dağılım 8-28) mm idi. On bir hastada, çoğunluğunda adenokarsinom olmak üzere (n=10) akciğer karsinomu var iken, 10 hastada FDG tutan tümör saptandı.18 F-FDG PET/BT'nin duyarlılığı, özgüllüğü ve doğruluğu, pozitif öngörü ve negatif öngörü değerleri sırasıyla %91, %63, %71, %50 ve %94 idi. Malignite tanısı konan hastaların tümü kadın ve ileri yaşta idi. Erkek hastalardan yalnız birinde malign nodül vardı.So nuç: Çalışmamızda adenokarsinom baskın olmakla birlikte, sigara içmeyen soliter pulmoner nodüllü hastalarda 18 F-FDG PET/BT'nin duyarlılığı ve negatif öngörü değeri yüksek bulundu.Anah tarsöz cük ler: Bilgisayarlı tomografi; florodeoksiglikoz; sigara içmeyenler; positron emisyon tomografi; soliter pulmoner nodül. ABSTRACTBackground: This study aims to investigate the diagnostic performance of fluorine-18-fluorodeoxyglucose positron emission tomography/computed tomography (

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18-Fluorine Fluorodeoxyglucose Positron Emission Tomography with Computerized Tomography Versus Computerized Tomography Alone for the Management of Solitary Lung Nodules with Diameters Inferior to 1.5 cm

Abstract: Our study shows that 18F-FDG PET/CT improves the identification and characterisation of potentially malignant pulmonary nodules with a diameter < 1 cm. This technique could be a valid alternative to a surgical approach, currently the main method to investigate indeterminate lung nodules.

Cited by 38 publications

References 16 publications

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Evaluation of Individuals With Pulmonary Nodules: When Is It Lung Cancer?

Clinical Management of Solitary Pulmonary Micronodule: A Pilot Study

Diagnostic performance of 18F-FDG PET/CT in solitary pulmonary nodules of non-smokers

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