18 Coupling CE and microchip-based devices with mass spectrometry

Schappler, Julie; Veuthey, Jean‐Luc; Rudaz, Serge

doi:10.1016/s0149-6395(07)00018-9

Cited by 19 publications

(16 citation statements)

References 389 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The on-line combination of highly efficient CE separations and MS is now well established and offers numerous major benefits. [10] As in many liquid-based separation techniques, electrospray ionization (ESI) is the predominant method for performance of on-line CE-MS. The advantages of ESI are simplicity, high ionization efficiency in terms of ions released from charged droplets, and ability to produce multiply charged ions.…”

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

New Insights in Pharmaceutical Analysis

Guillarme

Schappler²,

Bernard³

et al. 2012

Chimia

Self Cite

View full text Add to dashboard Cite

The research unit of pharmaceutical analytical chemistry (PAC) has been active in the field of separation sciences for many years. Liquid chromatography (LC) and its latest improvements such as ultra-high performance chromatography (UHPLC) and supercritical fluid chromatography (SFC) are deeply and thoroughly studied, from a fundamental viewpoint to its various application capabilities. Electro-driven separations such as capillary electrophoresis (CE) are also a major field of interest, especially for macromolecules, and low cost. All these techniques are investigated with various detection modes including mass spectrometry (MS) for various applications where high sensitivity and selectivity is needed. Extracting the relevant information from the overwhelming amount of data generated by modern analytical platforms has become an important issue for knowledge discovery in various research fields. The appropriate treatment of such data is therefore of crucial importance to provide valuable information. Numerous works in our research group have demonstrated the usefulness of statistical and mathematical methodologies to improve quality of the results. Therefore, well-established chemometric approaches (e.g. design of experiments, multivariate data analysis, etc.) are implemented to optimize the analytical process from method development to data analysis.

show abstract

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

New Insights in Pharmaceutical Analysis

Guillarme

Schappler²,

Bernard³

et al. 2012

Chimia

Self Cite

View full text Add to dashboard Cite

show abstract

“…The most generally used ionization technique for structure elucidation [135] and quantitative analytical application [136] is CE-ESI-MS. Microchip CE-MS, in turn, is a useful tool in biomicroanalysis [138]. CE-stacking is a useful tool for preconcentration prior to the MS analysis [137].…”

Section: Coupling Of Ms To Ce and Related Techniquesmentioning

confidence: 99%

The Role of Analytical Chemistry in the Safety of Drug Therapy

Gǒrög

2012

Analytical Techniques for Clinical Chemistry

View full text Add to dashboard Cite

“…In this configuration, the sheath liquid mixes with the CE effluent at the tip of the separation capillary, providing electrical contact at the outlet end of the capillary, and the appropriate flow rate and solvent conditions for ionization and evaporation of the analytes. [36][37][38] The main limitation of CE-ESI-MS concerns the use of volatile electrophoretic buffers (e.g. acetate, formate, carbonate, ammonium), and/or volatile selectivity modifiers to avoid the putative contamination of the ESI source.…”

Section: Spe With MCXmentioning

confidence: 99%

“…The sheath liquid was an iprOH-water mixture that afforded electrical connection to close the CE circuit and evaporation of CE effluent at the tip of the capillary. [37,48,51] Conventionally, a small percentage of acid is added to the hydro-organic mixture for basic compounds ionization (e.g. formic acid, TFA) to assist analyte protonation, and a small amount of ammonia is added to increase deprotonation of acidic compounds.…”

Section: Interface and Ms Conditionsmentioning

confidence: 99%

Single-Run Separation of Closely Related Cationic and Anionic Compounds by CE-ESI-MS: Application to the Simultaneous Analysis of Melamine and its Analogs in Milk

Köhler

Cognard

Marchi

et al. 2011

Chimia

Self Cite

View full text Add to dashboard Cite

In recent years, two adulteration incidents concerning the addition of melamine, a nitrogen-rich industrial small polar compound, to pet food and infant formula products have occurred in China. These issues prompted laboratories to develop methods for the analysis of melamine and related compounds in a wide variety of food products and ingredients. In this context, a CE-ESI-MS method was developed to simultaneously analyze melamine and its related products (ammeline, ammelide and cyanuric acid) that possess close physico-chemical properties. This method allows the simultaneous analysis of both cations and anions in a single run, using CE to divide the run into two time segments in normal polarity mode. For this purpose, ESI polarity was switched once during the run, increasing sensitivity and data quality. The method was applied to spiked powdered milk and melamine-contaminated powdered milk, with two sample preparation procedures.

show abstract

18 Coupling CE and microchip-based devices with mass spectrometry

Cited by 19 publications

References 389 publications

New Insights in Pharmaceutical Analysis

New Insights in Pharmaceutical Analysis

The Role of Analytical Chemistry in the Safety of Drug Therapy

Single-Run Separation of Closely Related Cationic and Anionic Compounds by CE-ESI-MS: Application to the Simultaneous Analysis of Melamine and its Analogs in Milk

Contact Info

Product

Resources

About