Abstract:Introduction
Atherosclerosis is a chronic inflammatory disease, in which foam cell macrophage (FCM) accumulation is initiated by hypercholesterolemia. Classical (M1) and alternative (M2) activation of FCMs could play important roles in atherosclerotic plaque progression and rupture, in part by increasing production of matrix metalloproteinases (MMPs), which directly destabilise plaques. Thelper1(Th1) lymphocytes are believed essential for classical macrophage activation in plaque by secreting cytokines includi… Show more
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