16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium

Ross, J I; Eady, E. Anne; Cove, Jonathan H.; Cunliffe, W. J.

doi:10.1128/aac.42.7.1702

Cited by 162 publications

(94 citation statements)

References 27 publications

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“…The gene tet(U) is responsible for low-level tetracycline resistance by unknown means (Ridenhour et al, 1996). Point mutations within the 16S rRNA (Ross et al, 1998) and mutations that alter the permeability of the porin channels (Bolhuis et al, 1997) also increase tetracycline resistance.…”

Section: How Bacteria Exhibit Resistancementioning

confidence: 99%

Are Sewage Treatment Plants Promoting Antibiotic Resistance?

Jury

Khan

Vancov

et al. 2011

Critical Reviews in Environmental Science and Technology

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There is widespread speculation that sewage treatment plants (STPs) and aquatic environments in general may be breeding grounds for antibiotic resistant bacteria. We examine the question of whether low concentrations of antibiotics in STPs can provide or contribute to a selective pressure facilitating the acquisition or proliferation of antibiotic resistance among bacteria in the receiving environment. Examination of available literature suggests that relative levels of antibiotic resistance may be increased during sewage treatment processes. However, it is unclear whether this may be partially the result of horizontal gene transfer or entirely due to clonal propagation. While there is circumstantial evidence that the presence of antibiotics or other related genetic promoters in STP wastewaters may contribute to selective pressures for these processes, a definite role is yet to be demonstrated. Future researchers would benefit from the application of non-culture-based techniques because culture limits the possible observations to a small subset of STP microbial diversity.

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Section: How Bacteria Exhibit Resistancementioning

confidence: 99%

Are Sewage Treatment Plants Promoting Antibiotic Resistance?

Jury

Khan

Vancov

et al. 2011

Critical Reviews in Environmental Science and Technology

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“…This decline was due to the emergence of resistant strains of bacteria. A number of mechanisms have been suggested including; reduction of the intracellular concentration of the compound through active efflux [22], disruption of the tetracycline-ribosomal interaction by ribosomal protection proteins (RPPs) [23], enzymatic inactivation of the drug through mono-hydroxylation [24] and alteration of the target site through 16S RNA mutation [25].…”

Section: Resistancementioning

confidence: 99%

Tetracyclines: Drugs with Huge Therapeutic Potential

Bahrami

Morris²,

Pourgholami³

2012

MRMC

128

101

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Tetracyclines are an amazing class of chemical agents with multiple therapeutic potential. Structural modification of the original natural tetracyclines led to the synthesis and development of doxycycline and minocycline, compounds with higher lipophilicity, better oral pharmacokinetics and higher potency. Due to diverse pharmacological properties, these drugs are now under extensive investigation for use in the treatment of various disparate diseases. In recent years, several studies have conclusively reported anti-inflammatory, immune-modulating and neuroprotective effects of these compounds. There are currently over 200 ongoing clinical trials on tetracyclines. These studies extend over a wide range of diseases including dermatological diseases, behavior and mental disorders, immune system disorders, cardiovascular diseases, and cancer. In this review we will discuss the chemistry and pharmacology of these agents, and describe how their inhibitory effect on matrix metalloproteinase and on pro-inflammatory cytokines has kindled renewed interest in them. Based on the reports from pre-clinical and clinical trials, the therapeutic potential and application of tetracyclines may well be redefined and extensively extended.

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“…Though tetracycline resistance in isolates of Propionibacterium acnes has been reported since the 1980s from various parts of the world [56][57][58], no systematic study to characterize the mechanism was conducted until 1998, when Ross et al [59] showed a point mutation (G ? C) at position 1,058 in 16S-rRNA to be responsible for the resistant phenotype.…”

Section: Target Modificationmentioning

confidence: 99%

The tetracycline resistome

Thaker

Spanogiannopoulos

Wright

2009

Cell. Mol. Life Sci.

285

244

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Resistance to tetracycline emerged soon after its discovery six decades ago. Extensive clinical and non-clinical uses of this class of antibiotic over the years have combined to select for a large number of resistant determinants, collectively termed the tetracycline resistome. In order to impart resistance, microbes use different molecular mechanisms including target protection, active efflux, and enzymatic degradation. A deeper understanding of the structure, mechanism, and regulation of the genes and proteins associated with tetracycline resistance will contribute to the development of tetracycline derivatives that overcome resistance. Newer generations of tetracyclines derived from engineering of biosynthetic genetic programs, semi-synthesis, and in particular recent developments in their chemical synthesis, together with a growing understanding of resistance, will serve to retain this class of antibiotic to combat pathogens.

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16S rRNA Mutation Associated with Tetracycline Resistance in a Gram-Positive Bacterium

Cited by 162 publications

References 27 publications

Are Sewage Treatment Plants Promoting Antibiotic Resistance?

Are Sewage Treatment Plants Promoting Antibiotic Resistance?

Tetracyclines: Drugs with Huge Therapeutic Potential

The tetracycline resistome

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