162 Two different hormone transporting systems in human blood: features of peptide hormone transport in human blood

Garipova, M.I.; Bashkatov, S. A.; Dazko, Olesya I.; Косова, А.А.; Migunova, Maria E.

doi:10.1080/07391102.2015.1032799

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“…Thus, the results emphasis that the proposed novel leads would be effective in treating oxidative stress mediated AD therapeutics. It is known that hydrophobic hormones can be transporting in blood by two mechanisms: in serum proteins complex and in internal volume of erythrocytes (Dolomatov et al, 1999;Eliseeva et al, 2009;Garipova & Usmanova, 2013;Garipova & Dazko, 2015;Garipova, Morugova, Kireeva, Ibragimov, & Baranova, 2010;Gimatdinova et al, 2011). It is interesting to answer the question of how the intracellular hormone concentration is related to it is concentration in each of hormone transporting systems.…”

Section: Referencesmentioning

confidence: 99%

Book of Abstracts. Albany 2019: The 20th Conversation

Sarma¹

2019

Journal of Biomolecular Structure and Dynamics

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The aim of structural biology is to explain life processes in terms of macromolecular interactions in the cell. These interactions typically involve more than two partners, and can run up to dozens. A full description will need to characterize all structures on the atomic level, and the way these structures change in the process. Because of the crowded environment of the cell, such characterization is presently (but see below) only possible when the group of interacting molecules (often organized into processive 'molecular machines') is isolated and studied in vitro. While X-ray crystallography has provided structures of a large number of molecular structures, the need for crystals diffracting to high resolution has severely limited the number of supramolecular assemblies and the range of conformers that can be studied with this technique. Single-particle cryo-electron microscopy is about to fill this gap, allowing functional processes to be studied in great detail without imposing restraints on the structures. There are many examples now for this expansion of Structural Biology toward a full characterization of a functional process. Future developments of single-particle cryo-EM include the study of short-lived intermediates in a nonequilibrium system by time-resolved techniques, and the characterization of continuous structural changes using data mining from large ensembles of molecule images. It is very interesting and promising that another technique of cryo-EM, cryo-electron tomography of FIB-milled cell sections, has started to contribute information about processes even within the cellular context. Distinct ribosome states, for instance, have already been identified and localized by subtomogram averaging. With this advance, we get closer to the fulfillment of the most ambitious aim of Structural Biology, the visualization and interpretation of molecular interactions in situ.

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Section: Referencesmentioning

confidence: 99%

Book of Abstracts. Albany 2019: The 20th Conversation

Sarma¹

2019

Journal of Biomolecular Structure and Dynamics

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162 Two different hormone transporting systems in human blood: features of peptide hormone transport in human blood

Cited by 1 publication

References 2 publications

Book of Abstracts. Albany 2019: The 20th Conversation

Book of Abstracts. Albany 2019: The 20th Conversation

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