Abstract:Calcific aortic valve disease (CAVD) involves progressive valve leaflet thickening and severe calcification, resulting in impaired leaflet motion. Although much research has advanced our knowledge of this disease, the mechanisms underlying the initiation and progression of CAVD are still unclear, necessitating further studies to elucidate the underpinning processes in the early stages of this disorder.Our present study aimed to (i) generate and (ii) evaluate the calcification potential of immortalised cell lin… Show more
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