2015
DOI: 10.1080/09168451.2015.1012149
View full text |Buy / Rent full text
Has correction 2015-7-3Has erratum 2015-7-3
|
Sign up to set email alerts
|

Abstract: Lipid-derived electrophilic molecules are endogenously generated and are causally involved in many pathophysiological effects. Prostaglandin D2, a major cyclooxygenase product in a variety of tissues and cells, readily undergoes dehydration to yield the J-series PGs such as 15-deoxy-Δ12,14-PGJ2 (15d-PGJ2). Because of the electrophilic α,β-unsaturated ketone moiety present in its cyclopentenone ring, 15d-PGJ2 acts as an endogenous electrophile. 15d-PGJ2 can covalently react via the Michael addition reaction wit… Show more

Help me understand this report
Editorial notices

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
2

Citation Types

0
17
0

Year Published

2016
2016
2020
2020

Publication Types

Select...
3
1

Relationship

0
4

Authors

Journals

citations
Cited by 25 publications
(51 citation statements)
references
References 53 publications
(51 reference statements)
0
17
0
Order By: Relevance
“…Indeed, 15d-PGJ 2 induces differentiation of rat embryonic midbrain cells into dopaminergic neuronal cells in a PPARγ-dependent manner [25]. Nevertheless, 15d-PGJ 2 is also involved in PPARγ-independent pathways via direct covalent binding to proteins other than PPARγ [47]; 15d-PGJ 2 enhances nerve growth factor-induced neurite outgrowth via covalent binding to activator protein-1 [48] or the transient receptor potential vanilloid 1 [49] in PC12 cells. These studies suggest that 15d-PGJ 2 -induced neuritogenesis and neuronal differentiation involve pathways that are dependent or independent of PPARγ, according to the cell type.…”
Section: Discussionmentioning
confidence: 99%
“…Indeed, 15d-PGJ 2 induces differentiation of rat embryonic midbrain cells into dopaminergic neuronal cells in a PPARγ-dependent manner [25]. Nevertheless, 15d-PGJ 2 is also involved in PPARγ-independent pathways via direct covalent binding to proteins other than PPARγ [47]; 15d-PGJ 2 enhances nerve growth factor-induced neurite outgrowth via covalent binding to activator protein-1 [48] or the transient receptor potential vanilloid 1 [49] in PC12 cells. These studies suggest that 15d-PGJ 2 -induced neuritogenesis and neuronal differentiation involve pathways that are dependent or independent of PPARγ, according to the cell type.…”
Section: Discussionmentioning
confidence: 99%
“…PGD2 has a relatively short half-life, after which it is further converted to various bioactive derivatives (Schuligoi et al, 2007;Shibata et al, 2002). Induction of ROS by PGD2 treatment may be attributed to 15-deoxy-delta-12,14-prostaglandin J2 (15d-PGJ2), a spontaneous electrophilic metabolite of PGD2 that has been shown to mediate some of its biological actions via ROS (Shibata, 2015;Wang and Mak, 2011). In addition to PGD2,15d-PGJ2 has been also found to be elevated in bald scalp, and its inhibitory effects on hair growth were more profound compared with the parental prostaglandin (Garza et al, 2012).…”
Section: Discussionmentioning
confidence: 99%
“…in several cell and potentially acts as an endogenous suppressor of inflammation (29, 30). There are a number of possible mechanisms for this activity (31). First, 15d-PGJ 2 is a ligand for peroxisome proliferator-activated receptor gamma (PPAR-γ), a member of the nuclear receptor superfamily and a transcription factor with pleiotropic effects on adipocyte differentiation, glucose homeostasis, lipid metabolism, cell growth, and inflammation (29, 32).…”
Section: Discussionmentioning
confidence: 99%
“…One of these products, PGD 2 , is an abundant prostaglandin in several tissues. PGD 2 activates G-protein-coupled receptors on its target cells, but PGD 2 also undergoes dehydration in vivo and in vitro to generate cyclopentenone metabolites of the J series, including 15-deoxy-delta 12,14 -prostaglandin J 2 (15d-PGJ 2 ) (2, 3). 15d-PGJ 2 represses inflammatory responses in several models, including modulation of genes such as iNOS, TNF-α, and COX-2 (4, 5).…”
Section: Introductionmentioning
confidence: 99%