13C-Urea Breath Test With Infrared Spectroscopy for Diagnosing Helicobacter pylori Infection in Children and Adolescents

Kawakami, Elisabetye; Machado, Rodrigo Strehl; Reber, Marialice; Patrı́cio, Francy Reis da Silva

doi:10.1097/00005176-200207000-00010

Cited by 48 publications

(43 citation statements)

References 32 publications

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“…13 C-UBT is highly sensitive (96.8%) and specific (93.2%), but it requires an expensive tracer and high-cost equipment (mass spectrometer or infrared spectrometer), which are not widely available. 31 The stool antigen test is a direct enzyme immunoassay for detecting H. pylori antigens in stool samples. This test is highly sensitive (94.6%) and specific (96.5%), and it only requires equipment that is available in most laboratories.…”

Section: Discussionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

et al. 2010

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CONTEXT AND OBJECTIVE: Helicobacter pylori infection is mainly acquired during childhood, and is associated with significant morbidity in adults. The aim here was to evaluate the seroprevalence and risk factors of H. pylori infection among children of low socioeconomic level attended at a public hospital in São Paulo, Brazil. DESIGN AND SETTING:Cross-sectional study, among patients attended at an outpatient clinic.METHODS: 326 children were evaluated (150 boys and 176 girls; mean age 6.82 ± 4.07 years) in a cross-sectional study. Patients with chronic diseases or previous H. pylori treatment, and those whose participation was not permitted by the adult responsible for the child, were excluded. The adults answered a demographic questionnaire and blood samples were collected. The serological test used was Cobas Core II, a second-generation test. Titers > 5 U/ml were considered positive. RESULTS: H. pylori infection was diagnosed in 116 children (35.6%). Infected children were older than uninfected children (7.77 ± 4.08 years versus 5.59 ± 3.86 years; p < 0.0001). The seroprevalence increased from 20.8% among children aged two to four years, to 58.3% among those older than 12 years. There were no significant relationships between seropositivity and gender, color, breastfeeding, number of people in the home, number of rooms, bed sharing, living in a shantytown, maternal educational level, family income or nutritional status. In multivariate analysis, the only variable significantly associated with H. pylori seropositivity was age.CONCLUSION: Infection had intermediate prevalence in the study population, and age was associated with higher prevalence. RESUMO CONTEXTO E OBJETIVO:A infecção por Helicobacter pylori é adquirida principalmente na infância e é associada a morbidade significativa em adultos.O objetivo foi avaliar a soroprevalência de infecção por H. pylori bem como fatores de risco em crianças de baixo nível socioeconômico atendidas em um hospital público em São Paulo, Brasil. TIPO DE ESTUDO E LOCAL:Estudo transversal, realizado entre pacientes atendidos em ambulatório. MÉTODOS:Foram avaliadas 326 crianças (150 meninos e 176 meninas, idade: média 6,82 ± 4,07 anos) em estudo transversal. Foram excluídas aquelas com doenças crônicas, tratamento prévio de H. pylori e cujo responsável não consentiu participar do estudo. Os responsáveis responderam questionário demográfico e foi coletada uma amostra de sangue. O teste sorológico empregado foi o CobasCore II, exame de segunda geração, sendo considerados positivos títulos > 5 U/ml. RESULTADOS:Infecção por H. pylori foi diagnosticada em 116 (35,6%). A idade dos pacientes infectados foi maior que a dos demais (7,77 ± 4,08 anos versus 5,59 ± 3,86 anos; p < 0,0001). A prevalência aumenta de 20,8% entre dois e quatro anos de idade para 58,3% entre maiores de 12 anos. Não houve relação significativa entre soropositividade e sexo, raça, aleitamento materno, número de pessoas ou de cômodos na casa, compartilhamento de camas, domicílio em favela, escolaridade mat...

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Section: Discussionmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

et al. 2010

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“…UBT has been validated (28,53,242,250,253,362,481,542) and is the most highly recommended noninvasive test for children. The protocol used in adults can be followed.…”

Section: Application In Different Clinical Settingsmentioning

confidence: 99%

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

2007

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SUMMARY The discovery of Helicobacter pylori in 1982 was the starting point of a revolution concerning the concepts and management of gastroduodenal diseases. It is now well accepted that the most common stomach disease, peptic ulcer disease, is an infectious disease, and all consensus conferences agree that the causative agent, H. pylori, must be treated with antibiotics. Furthermore, the concept emerged that this bacterium could be the trigger of various malignant diseases of the stomach, and it is now a model for chronic bacterial infections causing cancer. Most of the many different techniques involved in diagnosis of H. pylori infection are performed in clinical microbiology laboratories. The aim of this article is to review the current status of these methods and their application, highlighting the important progress which has been made in the past decade. Both invasive and noninvasive techniques will be reviewed.

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“…The test was validated for adults in Brazil on 1999 (26) and for adolescents and children on 2002 (106) . Although highly accurate, simple and relatively cheap, the test has not yet been incorporated into daily gastroenterology practice, its use being restricted to large urban centers and for epidemiological studies.…”

Section: Statementmentioning

confidence: 99%

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

Coelho

Maguinilk

Zaterka³

et al. 2013

Arq. Gastroenterol.

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Significant progress has been obtained since the Second Brazilian Consensus Conference on Helicobacter pylori Infection held in 2004, in São Paulo, SP, Brazil, and justify a third meeting to establish updated guidelines on the current management of H. pylori infection. The Third Brazilian Consensus Conference on H pylori Infection was organized by the Brazilian Nucleus for the Study of Helicobacter, a Department of the Brazilian Federation of Gastroenterology and took place on April 12-15, 2011, in Bento Gonçalves, RS, Brazil. Thirty-one delegates coming from the five Brazilian regions and one international guest, including gastroenterologists, pathologists, epidemiologists, and pediatricians undertook the meeting. The participants were allocated in one of the five main topics of the meeting: H pylori, functional dyspepsia and diagnosis; H pylori and gastric cancer; H pylori and other associated disorders; H pylori treatment and retreatment; and, epidemiology of H pylori infection in Brazil. The results of each subgroup were submitted to a final consensus voting to all participants. Relevant data were presented, and the quality of evidence, strength of recommendation, and level of consensus were graded. Seventy per cent and more votes were considered as acceptance for the final statement. This article presents the main recommendations and conclusions to guide Brazilian doctors involved in the management of H pylori infection.

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13C-Urea Breath Test With Infrared Spectroscopy for Diagnosing Helicobacter pylori Infection in Children and Adolescents

Abstract: 13C-urea breath test performed with infrared spectroscopy is a reliable, accurate, and noninvasive diagnostic tool for detecting H. pylori infection.

Cited by 48 publications

References 32 publications

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Seroprevalence of Helicobacter pylori infection among children of low socioeconomic level in São Paulo

Helicobacter pyloriDetection and Antimicrobial Susceptibility Testing

3rd BRAZILIAN CONSENSUS ON Helicobacter pylori

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