1068 The Presence of Microscopic Disease at the Resection Margins Predicts Post-Surgical Relapse in Crohn's Disease

Kinchen, James; Rajaratnam, Kowsala; Kingston, Gearoid; Mee, Anthony S.; Silva, Aminda N. De

doi:10.1016/s0016-5085(12)60711-2

Cited by 6 publications

(2 citation statements)

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“…Smoking, which constitutes a risk factor for postoperative recurrences, was disproportionately higher in patients undergoing conventional resection. Moreover, in group A, mucosal margins appeared histologically involved by the disease in 79% vs. 16% in group B [ 54 ], and a strong association between positive intestinal resection margins and increased risk of surgical recurrence of CD has been shown [ 55 ]. Currently, a large multicenter randomized controlled trial is undergoing, and the results should confirm or confound Coffey's hypothesis [ 56 ].…”

Section: Clinical Course and Surgical Treatmentsmentioning

confidence: 99%

The Role of Active Inflammation and Surgical Therapy in Crohn’s Disease Recurrence

Ingallinella

Campanelli

Antonelli

et al. 2020

Gastroenterology Research and Practice

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An altered balance between effector and regulatory factors is supposed to sustain the tissue-damaging immune response in inflammatory bowel disease (IBD). Several studies demonstrate that severe active inflammation is a strong predictor for surgical complications and recurrence. Indeed, bowel resection in Crohn’s disease (CD) patients has a high surgical recurrence rate. In this review, we examined the IBD inflammatory pathways, the current surgical treatments, and the almost inevitable recurrence. The question that might arise is if the cure of intestinal CD is to be found in the surgical approach. A selective search of two databases (PubMed and the Cochrane Library) has been carried out without considering a specific time horizon as inclusion criteria. The scope of this literature review was investigating on the role of inflammation in the management of CD. The following key words have been used to develop the query string: (i) inflammation; (ii) Crohn’s disease; (iii) surgery; and (iv) postsurgical recurrence.

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Section: Clinical Course and Surgical Treatmentsmentioning

confidence: 99%

The Role of Active Inflammation and Surgical Therapy in Crohn’s Disease Recurrence

Ingallinella

Campanelli

Antonelli

et al. 2020

Gastroenterology Research and Practice

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“…Other variables such as the type of surgery (for example, endtoend versus side toside anastomosis), certain genetic mutations, early age at onset of disease and lack of microscopic disease free margins of resection have been less consistently as sociated with an increased risk of POR. [30][31][32][33][34][35][36] Clearly, the absence of predictive factors for POR is what defines the patient at low risk. In addition, very limited bowel resection and long disease duration might be associated with a reduced risk of POR.…”

Section: Definitions Diagnosis and Risk Factorsmentioning

confidence: 99%

State-of-the-art medical prevention of postoperative recurrence of Crohn's disease

Sorrentino

2013

Nat Rev Gastroenterol Hepatol

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Postoperative recurrence of Crohn's disease is a frequent and often severe sequela of the disease. Until a few years ago it was deemed inescapable, as all the conventional medications used to treat the disease have been proven of little benefit in preventing recurrence after surgical treatment. In the past few years, anti-TNF agents given immediately after surgery have shown a remarkable efficacy in the prevention of disease recurrence. Large, randomized, controlled trials are currently underway to confirm these findings. Anti-TNF treatment of endoscopic lesions that occur after surgery seems to be less effective than using TNF antagonists to prevent recurrence. However, although the data are limited, this treatment strategy seems to be still superior to all the other prevention strategies that are not based on anti-TNF agents. Limited data are available on long-term outcomes of patients treated with anti-TNF agents after surgery. They suggest that these medications are safe and effective after many years of treatment. In addition, these agents might prevent recurrence even at doses lower than those used in patients with Crohn's disease who have not had surgery.

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Positive histologic margins is a risk factor of recurrence after ileocaecal resection in Crohn’s disease

Riault

Chatelain

Yzet

et al. 2021

Clinics and Research in Hepatology and Gastroenterology

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1068 The Presence of Microscopic Disease at the Resection Margins Predicts Post-Surgical Relapse in Crohn's Disease

Cited by 6 publications

References 0 publications

The Role of Active Inflammation and Surgical Therapy in Crohn’s Disease Recurrence

The Role of Active Inflammation and Surgical Therapy in Crohn’s Disease Recurrence

State-of-the-art medical prevention of postoperative recurrence of Crohn's disease

Positive histologic margins is a risk factor of recurrence after ileocaecal resection in Crohn’s disease

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