2021
DOI: 10.6061/clinics/2021/e2355
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Abstract: Liu Q, Zhang N, Li Z, He H. Efficacy of autologous platelet-rich plasma gel in the treatment of refractory pressure injuries and its effect on wound healing time and patient quality of life. Clinics (Sao Paulo).

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Cited by 11 publications
(12 citation statements)
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“…It shows that the effect of conventional treatment on relieving the pain of patients is not obvious, although the use of PRP or VSD can relieve the pain, the effect is less than the combination of the two. Liu et al [ 26 ] evaluated the efficacy of PRP gel in the treatment of refractory pressure injury and its effect on wound healing time and patients' quality of life, and the results were similar to this study. The time of complete wound healing in group D was 24.5 ± 2.32 days, which was significantly shorter than that in groups A, B, and C, and the difference had statistical significance ( P < 0.05).…”
Section: Discussionsupporting
confidence: 78%
“…It shows that the effect of conventional treatment on relieving the pain of patients is not obvious, although the use of PRP or VSD can relieve the pain, the effect is less than the combination of the two. Liu et al [ 26 ] evaluated the efficacy of PRP gel in the treatment of refractory pressure injury and its effect on wound healing time and patients' quality of life, and the results were similar to this study. The time of complete wound healing in group D was 24.5 ± 2.32 days, which was significantly shorter than that in groups A, B, and C, and the difference had statistical significance ( P < 0.05).…”
Section: Discussionsupporting
confidence: 78%
“…However, there is a little evidenced to suggest the routine use of the PRP in pressure ulcers. 36 This fact is consistent with the proposals of some government bodies, such as the Spanish Agency for Medicines and Health Products, which encourage researchers to carry out properly designed clinical trials to establish adequate levels of evidence in each of the pathologies that merit the use of PRP 37 or with the conclusions of some systematic reviews regarding the need for randomized clinical trials to evaluate the use of PRP in wound management. 38 Currently, there are not a significant number of publications related to the use of PRP in PI or studies in the management of other types of ulcers and in the general management of both acute and chronic wounds.…”
Section: Discussionsupporting
confidence: 70%
“…12 , 38 , 50 , 57 Recently, a study using negative pressure wound therapy plus PRP gel found an acceleration in ulcer closure times related to patients with refractory treatment. 36 These findings indicate the use of PRP as the treatment of choice for the topical care of chronic wounds. In fact, it is proposed that health services that care for patients with chronic wounds should ensure that any patient who requires it can benefit from the use of PRP.…”
Section: Discussionmentioning
confidence: 94%
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“…The WBP theory focuses on the following four aspects of the wound that affect healing, namely, TIME: T (tissue nonviable) necrotic tissue, I (infection or inflammation) infection or inflammation, M (moisture imbalance) wet balance, and E (edge of wound) wound margin [ 12 ]. The TIME system was originally proposed by Schultz et al [ 13 ], who focused on removing the bacterial, necrotic and cellular load affecting the wound surface, trying to maintain the wet balance of the wound surface, using various biological factors to actively create a relatively appropriate wound microenvironment, and accelerating wound healing or creating conditions for surgery. Supported by these scientific theories, the effect of silver ion dressing covering caused a hot debate.…”
Section: Discussionmentioning
confidence: 99%