2020
DOI: 10.6061/clinics/2020/e1596
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Abstract: OBJECTIVES: Anemia and changes in platelets (PLT) are common in inflammatory bowel disease (IBD). In our study, we aimed to verify whether PLT count can independently reflect the severity of IBD. METHODS: In our hospital, 137 Crohn’s Disease (CD), 69 Ulcerative colitis (UC) patients, and 412 healthy controls were included to compare the differences in PLT count. In addition, the effect of anemia, C-reactive protein (CRP), age, CD activity index (CDAI) or Mayo on PLTs wa… Show more

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Cited by 7 publications
(3 citation statements)
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“…In our study, we also found higher platelet count levels in ISBCD with small bowel ulcers than in OSBUD. This finding is consistent with Li et al [ 30 ]. Although our median platelet count level of 268 × 10 9 /L was lower than their reported level of 294.58 × 10 9 /L, this difference may be related to the selection of a specific CD population in our study.…”
Section: Discussionsupporting
confidence: 94%
“…In our study, we also found higher platelet count levels in ISBCD with small bowel ulcers than in OSBUD. This finding is consistent with Li et al [ 30 ]. Although our median platelet count level of 268 × 10 9 /L was lower than their reported level of 294.58 × 10 9 /L, this difference may be related to the selection of a specific CD population in our study.…”
Section: Discussionsupporting
confidence: 94%
“…PLTs are involved in active disease periods and not only regulate coagulation but also enhance mucosal in ammation [28]. PLT changes have been described in IBD and include morphological alterations (mean platelet volume (MPV), platelet distribution width (PDW) and PCT) and count increases, which are linked to PLT activation induced by in ammatory agonists [29,30]. MPV was negatively correlated with some in ammation markers, including CRP and ESR [31], while PCT percentages were markedly correlated with CRP and ESR [32].…”
Section: Discussionmentioning
confidence: 99%
“…The haematological parameters of the TGN group have shown significant improvement (*p < 0.05) as compared to the TNBS group. Many kinds of the literature revealed a substantial increase in the platelet count associated with IBD conditions [48][49][50]. Moreover, in human IBD is reported with 50-70% increase in circulating platelet count [51].…”
Section: Haematologymentioning
confidence: 99%