2020
DOI: 10.6061/clinics/2020/e1528
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Abstract: OBJECTIVES: Many studies indicate that microRNAs (miRNAs) could be potential biomarkers for various diseases. The purpose of this study was to investigate the clinical value of serum exosomal miRNAs in systemic lupus erythematosus (SLE). METHODS: Serum exosomes were isolated from 38 patients with SLE and 18 healthy controls (HCs). The expression of miR-21, miR-146a and miR-155 within exosomes was examined by reverse transcription-quantitative polymerase chain reaction (… Show more

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Cited by 34 publications
(24 citation statements)
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References 30 publications
(37 reference statements)
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“…The EVs of SLE patients' blood samples contained more IgG, IgM, and C1q than those of the control group [21]. Additionally, it was confirmed that miR-21 and miR-155 were significantly increased in blood EVs extracted from SLE patients [46]. Plasma EVs of patients with severe psoriasis showed significantly increased IL-17 and miR-199a [9,14].…”
Section: Extracellular Vesicles As Biomarkers For Diagnosis Of Skin Diseasesmentioning
confidence: 72%
“…The EVs of SLE patients' blood samples contained more IgG, IgM, and C1q than those of the control group [21]. Additionally, it was confirmed that miR-21 and miR-155 were significantly increased in blood EVs extracted from SLE patients [46]. Plasma EVs of patients with severe psoriasis showed significantly increased IL-17 and miR-199a [9,14].…”
Section: Extracellular Vesicles As Biomarkers For Diagnosis Of Skin Diseasesmentioning
confidence: 72%
“…Differentially-expressed circulating miRNAs have been found in patients with various glomerular diseases, such as IgA nephropathy and lupus nephritis [33,34]. Signi cant differences in the expression pro les of urinary and circulating exosomal miRNAs have also been observed between HVs and patients with IMN [35,36].…”
Section: Discussionmentioning
confidence: 99%
“…Accumulated data has shown that miRNAs disruption and dysfunction can interfere with immune response, stimulate inflammatory cytokines release, initiate autoantibodies production and promote autoimmune diseases occurrence, such as SLE ( 62 , 63 ). The expression of miR-146a in SLE patients serum exosomes is significantly decreased, which can promote MSCs senescence by targeting TRAF6 and inhibiting NF-κB signaling pathway activation ( Figure 1 ) ( 64 , 65 ). Besides, exosomal miR-146a plays a key role in regulating innate immunity by targeting toll-like receptors (TLRs), tumor necrosis factor (TNF)-associated family (TNAF), and interleukin-1 receptor-associated kinase 1 (IRAK1) ( Table 1 ) ( 66 ).…”
Section: Immunoregulatory Effects Of Mscs and Msc-evs On T Cellsmentioning
confidence: 99%