2019
DOI: 10.6061/clinics/2019/e631
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Abstract: OBJECTIVE: Primary Sjögren's syndrome (pSjS) is a chronic autoimmune disease that causes dry eye and mouth. No laboratory parameters to monitor the activation of this disease have been identified. Therefore, any possible relationships between salivary and blood myxovirus resistance 1 (MX1) and pSjS must be prospectively studied. METHODS: Thirty female patients with pSjS, 30 women with rheumatoid arthritis (RA) without secondary Sjögren's syndrome (SjS) and 28 healthy co… Show more

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Cited by 6 publications
(4 citation statements)
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“…LAMP3 was the third most upregulated DEG in our results, in agreement with previous studies that also reported elevated LAMP3 levels in SS (62,117). MX1 has also been found elevated in other cohorts of SS patients, including conjunctiva (13,14), labial salivary biopsies (53,62,127,128), and serum (129). When comparing our DEGs with previous studies that performed comprehensive gene analysis of the conjunctiva, our studies identified four overlapping DEGs (MX1, C2, CFB, STAT1, STAT2) (13,14).…”
Section: Genessupporting
confidence: 91%
“…LAMP3 was the third most upregulated DEG in our results, in agreement with previous studies that also reported elevated LAMP3 levels in SS (62,117). MX1 has also been found elevated in other cohorts of SS patients, including conjunctiva (13,14), labial salivary biopsies (53,62,127,128), and serum (129). When comparing our DEGs with previous studies that performed comprehensive gene analysis of the conjunctiva, our studies identified four overlapping DEGs (MX1, C2, CFB, STAT1, STAT2) (13,14).…”
Section: Genessupporting
confidence: 91%
“…Combined with previous studies, we speculate that HSP90AA1 may also be involved in the immune mechanism of vitiligo. Myxovirus Resistance 1 (MX1, also known as MxA) is the main mediator of IFN-based antiviral reactions, and MX1 is strongly affected by type 1 IFN 27 . Mx1 can cause hindrance in replication of RNA and DNA viruses 28 .…”
Section: Discussionmentioning
confidence: 99%
“…Furthermore, at least five of the differentially expressed genes ( Icam1, Batf, S100a9, Mx1 , and Irf7 ) evaluated by a NanoString® panel from murine conjunctivae subjected to desiccating stress were also upregulated in the conjunctiva of SS patients 269 . Some of these genes have been implicated in the SS and dry eye before 270 279 . Of particular interest is BATF.…”
Section: Dry Eye Diseasementioning
confidence: 99%