2019
DOI: 10.6061/clinics/2019/e630
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Abstract: OBJECTIVES: Cystathionine β-synthase is a major enzyme in the metabolism of plasma homocysteine. Hyperhomocysteinemia is positively associated with hypertension and stroke. The present study was performed to examine the possible effects of Cystathionine β-synthase promoter methylation on the development of hypertension and stroke. METHODS: Using quantitative methylation-specific PCR, we determined the Cystathionine β-synthase methylation levels in 218 healthy individual… Show more

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Cited by 30 publications
(27 citation statements)
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“…Recently, Wang et al described DNA hypermethylation in the CBS promoter and its association with increased risk of stroke in human populations. Hypermethylation of CBS leads to low enzyme activity, plasma homocysteine accumulation, and increased susceptibility to stroke [47]. High levels of plasma homocysteine are also associated with DNA hypermethylation of thrombomodulin (TM) in patients with IS.…”
Section: Dna Methylation In Ismentioning
confidence: 99%
“…Recently, Wang et al described DNA hypermethylation in the CBS promoter and its association with increased risk of stroke in human populations. Hypermethylation of CBS leads to low enzyme activity, plasma homocysteine accumulation, and increased susceptibility to stroke [47]. High levels of plasma homocysteine are also associated with DNA hypermethylation of thrombomodulin (TM) in patients with IS.…”
Section: Dna Methylation In Ismentioning
confidence: 99%
“…The association of HHcy with hypertension and stroke [113] was found to depend on DNA methylation [114]. Specifically, a study examining the effects of methylation on the development of hypertension and stroke (stroke n = 132, hypertension n = 243, controls n = 218) has found that hypertensive and stroke patients had higher methylation levels in the CBS gene promoter compared with healthy controls.…”
Section: Hhcy and Dna Methylationmentioning
confidence: 99%
“…The characteristics of eligible studies were shown in Supplementary Table 2. Of the 20 studies, 17 were casecontrol studies (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42), two were prospective cohort studies (43,44), and one was a cross-sectional study (45). Participants of the included studies were mostly older adults, with mean age ranging from 47.4 to 75.0 years.…”
Section: Summary Of Findingsmentioning
confidence: 99%
“…Eighteen studies had an independent evaluation for the diagnosis of IS and claimed the use of imaging tests such as brain computed tomography, magnetic resonance imaging, or magnetic resonance diffusion weighted imaging (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)44). Nineteen out of 20 studies assessed DNA methylation from acute/subacute stroke patients (26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43)(44). Seventeen studies were assessed as high or medium-quality, and three studies were evaluated as low-quality (Supplementary Table 3 for casecontrol studies, Supplementary Table 4 for cohort studies and cross-sectional studies).…”
Section: Summary Of Findingsmentioning
confidence: 99%
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