2018
DOI: 10.6061/clinics/2018/e150
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: OBJECTIVES:Dietary omega-3 fatty acids have been efficacious in decreasing serum cholesterol levels and reducing the risk of cardiovascular disease. However, the metabolic and molecular changes induced by the omega-3 fatty acid α-linolenic acid (ALA), which is found in linseed oil, are not fully understood. In this study, we showed a correlation between ALA and insulin resistance, inflammation and endoplasmic reticulum stress (ERS).METHODS:We studied 40 male mice (C57/BL6) divided into 4 groups: a control (C) … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
5

Citation Types

2
14
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 20 publications
(16 citation statements)
references
References 33 publications
2
14
0
Order By: Relevance
“…In contrast, treadmill exercise did not seem to effectively reverse the alterations of autophagy markers observed in 18-month-old DIO mice. Our data are similar to the results obtained in a recent study in mice fed a HFD for 12 weeks and then subjected to 8 weeks of treadmill exercise, showing no significant changes on autophagy/lipophagy markers [90]. However, a previous study conducted in younger mice (8-week-old) fed a Western diet for 4 weeks, followed by 4 weeks of voluntary wheel running, showed a stimulatory action of exercise on autophagy characterized by greater LC3II/I ratio and lower p62 protein [40].…”
Section: Discussionsupporting
confidence: 92%
See 1 more Smart Citation
“…In contrast, treadmill exercise did not seem to effectively reverse the alterations of autophagy markers observed in 18-month-old DIO mice. Our data are similar to the results obtained in a recent study in mice fed a HFD for 12 weeks and then subjected to 8 weeks of treadmill exercise, showing no significant changes on autophagy/lipophagy markers [90]. However, a previous study conducted in younger mice (8-week-old) fed a Western diet for 4 weeks, followed by 4 weeks of voluntary wheel running, showed a stimulatory action of exercise on autophagy characterized by greater LC3II/I ratio and lower p62 protein [40].…”
Section: Discussionsupporting
confidence: 92%
“…These data are in agreement with those observed by Kandeil et al [89] evidencing a marked reduction of Xbp1 mRNA levels and other ER stress biomarkers (CHREBP, CHOP, GRP78) in liver of young rats supplemented with n-3 PUFA, in parallel with the reduction of hepatic lipid content. The study of Gonçalves et al [90] has also found reduced expression of hepatic Xbp1 after dietary supplementation with the n-3 PUFA α-linolenic acid (ALA). Moreover, it has been shown that DHA ameliorates fructose-induced hepatic steatosis by modulating ER stress response (reducing Xbp1 mRNA and pIRE1α and IRE1α levels) in primary mouse hepatocytes [91].…”
Section: Discussionmentioning
confidence: 99%
“…This study demonstrated that PS-ALA was capable of ameliorating hepatic steatosis as well as optimizing lipid profiles, weakening inflammation, mitigating liver damage, and inhibiting oxidative stress induced by chronic lard-based HFD, which implied that PS attaching ALA had a good effect on protecting against NAFLD. Our results were supported by existing evidence showing that 7 Oxidative Medicine and Cellular Longevity ALA prevented hepatic steatosis in HFD-feeding mice [21] and intake of β-sitosterol and stigmasterol alleviated NAFLD in western-style HFD-feeding mice [22].…”
Section: Discussionsupporting
confidence: 89%
“…Excessive growth of WAT, abnormal glucose metabolism, and lipid metabolism disorders are the basic physiological phenomena induced by a high-fat diet. Previous studies have shown that ALA or ALA-enriched diets alter body composition, improve glucose tolerance, and attenuate IR ( 17 19 ). Supplementation of ALA improves serum adiponectin levels and insulin sensitivity in patients with type 2 diabetes ( 20 ).…”
Section: Discussionmentioning
confidence: 99%