Predictive value of C-reactive protein in critically ill patients after abdominal surgery

Sapin, Frédéric; Biston, Patrick; Piagnerelli, Michaël

doi:10.6061/clinics/2017(01)05

Cited by 8 publications

(5 citation statements)

References 35 publications

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“…4,13 CRP has been implicated in a number of inflammation-related diseases, including atherosclerosis/coronary artery disease, sepsis and serious bacterial infections, and tissue injury secondary to trauma or surgery. 14,15 The many physiologic roles of CRP include mediating coagulation and platelet aggregation, neutrophil activation, apoptotic signaling, stimulation of pro- and anti-inflammatory cytokines, complement activation, and antigen presentation. 14 The precise mechanisms resulting in the association between CRP and ferritin with mortality in the present cohort are unclear, and it is possible that elevations of these biomarkers reflect related but distinct inflammatory pathways and insults.…”

Section: Discussionmentioning

confidence: 99%

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

Horvat

Bell

Kantawala

et al. 2019

Clin Pediatr (Phila)

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Our objective was to determine if C-reactive protein (CRP) and ferritin values alone and in combination are associated with mortality among hospitalized children. All hospitalized patients at our institution with a CRP or ferritin assay in 2015 and 2016 were included. Area under the receiver operating curves (AUROC) were examined, optimal cut-points determined, and patients were stratified into low-, intermediate-, or high-risk groups based on elevation of zero, one, or both biomarkers. A total of 14 928 CRP and 653 ferritin values were obtained, with both obtained for 172 patients. AUROC for maximum CRP value was 0.76 (0.68-0.85) with a cut-point of 7.1 mg/dL for in-hospital mortality and 0.90 (0.83-0.98) for maximum ferritin with a cut-point of 373 ng/mL. Elevation of both ferritin and CRP was associated with the highest inpatient mortality (21.7%) and greatest organ dysfunction, followed by either biomarker alone. Additional prospective study of these biomarkers in combination is warranted.

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Section: Discussionmentioning

confidence: 99%

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

Horvat

Bell

Kantawala

et al. 2019

Clin Pediatr (Phila)

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“…Published studies have associated IAI with a prolonged morbidity and significant mortality rate [16,17,18,19,20]. This situation can be associated with some reasons, for example, inadequate empirical antibacterial treatment and poor inflectional control that leads to increasing bacterial resistance [21,22].…”

Section: Discussionmentioning

confidence: 99%

“…IAI are still regarded as an important cause of morbidity and mortality worldwide, despite antibiotics application [16,17]. These infections are caused by Gram-negative, aerobic, and anaerobic mandatory and often mixed bacterial flora [18].…”

Section: Introductionmentioning

confidence: 99%

Serum Interleukin-8 in Patients with Different Origin of Intra-Abdominal Infections in Perioperative Period

2019

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Intra-abdominal infections (IAI) are associated with high levels of pro-inflammatory serum IL-8 and poor outcomes, but data on IL-8 levels in various inflammatory reactions are contradictory. A better understanding of the diagnostic role of IL-8 is important, since the clinical relevance remains unclear. Methods: That was a single-center observational longitudinal cross-sectional study included 56 patients with various origins of intra-abdominal infections: 24 patients with postoperative abscesses, 12 patients with primary intra-abdominal abscesses, and 20 patients with diffuse peritoneal collection. Perioperative serum concentrations of interleukin-8 IL-8 were investigated at the day before surgery, on the 2nd–3rd day, and on the 5th–7th day after surgery. The hypothesis suggested that there was a difference in serum IL-8 in patients with IAI of different origin in the perioperative period. Results: The study showed that the level of serum IL-8 in patients with intra-abdominal infections of different origins is lower in comparison with healthy individuals. Despite the fact that we did not detect any statistically significant differences in the level of IL-8 in serum in IAI of different origin in the perioperative period, its lowest index was observed in the patients with postoperative abscesses on the 5th–7th days after surgical intervention. The levels of serum IL-8 ≤49.71 pg/mL and ≤48.88 pg/mL may serve as diagnostic markers for primary and postoperative abscesses with significant sensitivity and specificity. Conclusions: Our results differ from previous studies that showed high serum IL-8. High-quality clinical trials are needed to better comprehend the role of inflammatory mediators in IAI with different origin.

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“…Despite its common clinical use, few studies have examined CRP levels as a biomarker of infection in critically ill patients, and the results have not been consistent (Sapin, 2017). Apart from CRP, other clinical inflammatory indicators are white blood cells (WBC) and their sub-populations, which play an important role in the assessment, diagnosis, and prognosis of inflammation in critically ill patients.…”

Section: Introductionmentioning

confidence: 99%

Research Connections: Association of opioid analgesics and sedation with inflammatory markers in critically ill patients: a retrospective descriptive exploratory study

Charalambous¹,

Papavasiliou²,

Middleton³

et al. 2018

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SUMMARYMedical care of critically ill patients is complex and resource intensive. Systemic inflammation is a usual problem among critically ill patients; however, the effects of common medications on inflammation has not been adequately studied.Aim: To explore associations between sedation and opioid analgesics with common inflammatory markers in critically ill patients treated in intensive care units (ICU).Methods: This is a retrospective descriptive correlational study. The study was conducted at the ICU of the biggest Cyprus general hospital and involved all patients hospitalized during the year 2013. Purposive sampling was used. Collection of data was carried out through the ICU electronic data.Results: There is no apparent association of opiate analgesics and suppressants with the CRP.Conclusion: There was no significant association between the use of opiate analgesics and sedatives and inflammatory indicators. There is a need for further research to investigate potential associations between pharmacotherapy and inflammatory markers in critically ill patients giving emphasis on confounding variables, such as patients’ clinical characteristics and severity.

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Predictive value of C-reactive protein in critically ill patients after abdominal surgery

Cited by 8 publications

References 35 publications

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

C-Reactive Protein and Ferritin Are Associated With Organ Dysfunction and Mortality in Hospitalized Children

Serum Interleukin-8 in Patients with Different Origin of Intra-Abdominal Infections in Perioperative Period

Research Connections: Association of opioid analgesics and sedation with inflammatory markers in critically ill patients: a retrospective descriptive exploratory study

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