Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome

Maciel, Gustavo Arantes Rosa; Moreira, Ricardo P. P.; Bugano, Diogo Diniz Gomes; Hayashida, Sylvia Asaka Yamashita; Marcondes, José Antônio Miguel; Gomes, Larissa; Mendonça, Berenice Bilharinho; Bachega, Tânia A. S. S.; Baracat, Edmund C.

doi:10.6061/clinics/2014(03)06

Cited by 8 publications

(10 citation statements)

References 33 publications

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“…29 The BclI variant is also associated with a lower frequency of insulin resistance in women with polycystic ovary syndrome. 30 These facts may support the hypothesis that BclI polymorphism has negative metabolic implications. The clinical significance of screening glucocorticoid gene polymorphism may be useful for identifying subgroups of patients at-risk who would benefit the most from personalized treatment.…”

Section: Polymorphism Bclisupporting

confidence: 73%

Glucocorticoid receptor polymorphism in obesity and glucose homeostasis

Majer-Łobodzińska¹,

Adamiec-Mroczek²

2017

Adv Clin Exp Med

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Glucocorticoid receptor (GR) activity plays a significant role in the etiology of obesity and is essential for glucose homeostasis, the development of hyperinsulinaemia and subsequent increased fat deposition. Several polymorphisms in the GR gene have been described, and at least three of them seem to be associated with altered glucocorticoid sensitivity and changes in glucose homeostasis, and other metabolic parameters. The N363S polymorphism has been associated with increased sensitivity to glucocorticoides, increased insulin response to dexamethasone and increased plasma glucose level. BclI polymorphism is associated with increased abdominal obesity, hyperinsulinaemia and increased insulin resistance. Another polymorphism, ER22/23EK, in contrast to the others, is associated with relative resistance to glucocoricides actions and more beneficial metabolic profile-lower insulin resistance level, decreased lower cardiovascular risk and subseuent prolongation of life time. More research is still needed to understand the mechanisms behind these associations at the molecular level.

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Section: Polymorphism Bclisupporting

confidence: 73%

Glucocorticoid receptor polymorphism in obesity and glucose homeostasis

Majer-Łobodzińska¹,

Adamiec-Mroczek²

2017

Adv Clin Exp Med

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“…Previous studies have shown a clear association of overweight/obesity with the pathophysiology of PCOS 30–32 . Increased BMI, especially when associated with central obesity, is linked to insulin resistance and compensatory hyperinsulinemia, ovulatory dysfunction, metabolic syndrome, and increased cardiovascular risk 33 .…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have shown a clear association of overweight/ obesity with the pathophysiology of PCOS. [30][31][32] Increased BMI,…”

Section: Discussionmentioning

confidence: 99%

Prevalence of metabolic disturbances among women with polycystic ovary syndrome in different regions of Brazil

Maffazioli

Lopes

Heinrich-Oliveira

et al. 2020

Intl J Gynecology & Obste

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Objective: To describe the prevalence of metabolic disturbances in a large cohort of women with polycystic ovary syndrome (PCOS) in southeastern Brazil and to compare the findings with other cohorts of Brazilian women with PCOS. Methods: A retrospective study analyzing clinical and laboratory data of 462 women with PCOS treated at an outpatient clinic in a tertiary hospital in southeastern Brazil. Prevalence of insulin resistance, glucose intolerance, type 2 diabetes, dyslipidemia, central obesity, hypertension, and metabolic syndrome was compared to that of other cohorts of age and body mass index-matched Brazilian women with PCOS. Results: Women with PCOS had a median age of 25.0 (21.0-29.0) years and BMI of 28.7 (23.9-34.0) kg/m 2. Prevalence of insulin resistance, glucose intolerance, and type 2 diabetes varied from 39.6% to 55.0%, 7.2% to 28.1%, and 2.0% to 4.1%, respectively. Prevalence of central obesity, dyslipidemia due to decreased high-density lipoprotein cholesterol, hypertriglyceridemia, and metabolic syndrome ranged from 57.8% to 66.4%, 54.1% to 70.4%, 22.9% to 35.1%, and 27.4% to 38.3%, respectively, which did not differ among regions in Brazil. Conclusion: Prevalence of metabolic disturbances was high among Brazilian women with PCOS. This study suggests that, from a public health perspective, authorities in Brazil should be aware of and encourage screening for metabolic dysfunction in women with PCOS in all regions of the country.

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“…Table 1 summarizes the characteristics of studies on Brazilian populations. Seven studies were from the Northeast region [23][24][25][26][27][28][29], thirteen studies were from the Southeast [30][31][32][33][34][35][36][37][38][39][40][41][42], five studies were from the South [43][44][45][46][47], and two studies were from the Midwest region [48,49]. No data from the North region were available.…”

Section: Discussionmentioning

confidence: 99%

“…Another one study was excluded from the meta-analyses because the control group included participants who were hirsute or had irregular menses [36]. Two studies in which data on PCOS participants were presented only as PCOS phenotypes [35,43] and other two studies that did not present SD values for the variables of interest [29,34] were equally excluded from the meta-analyses. In Brazilian women with PCOS, BMI ranged from 24.2 to 31.9 kg/m 2 ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Spritzer

Ramos

Marchesan

et al. 2021

Diabetol Metab Syndr

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Background Polycystic ovary syndrome (PCOS) is a common endocrine disease affecting women of reproductive age and associated with reproductive and metabolic dysfunction. Few studies are available regarding metabolic traits in Brazilian women with PCOS. The aim of this systematic review and meta-analysis was to summarize the available evidence regarding metabolic traits and comorbidities in Brazilian women with polycystic ovary syndrome (PCOS). Methods We systematically searched PubMed, Cochrane Central Register of Controlled Trials, and Embase for cross-sectional, case–control, or cohort studies focusing on populations of different regions from Brazil, published until July 31, 2019. Studies were selected if they reported PCOS diagnostic criteria. Studies without a control group were included if they presented relevant metabolic data. Results Of 4856 studies initially identified, 27 were included in the systematic review and 12 were included in the meta-analysis, for a total of 995 women with PCOS defined by Rotterdam criteria and 2275 controls from different regions of Brazil. Obesity, metabolic syndrome and IGT were prevalent, and standard mean differences for BMI (SMD 0.67, 95% CI, 0.29, 1.05), waist circumference (SMD 0.22, 95% CI 0.02, 0.41), systolic (SMD 0.66, 95% CI 0.30, 1.01) and diastolic blood pressure (SMD 0.55, 95% CI 0.24, 0.87), glucose (SMD 0.21, 95% CI 0.04, 0.38) and HOMA (SMD 0.78, 95% CI 0.52, 1.04) were significantly higher in Brazilian women with PCOS compared to controls. Lipid profile was more adverse in PCOS vs. non-PCOS women. Between-study heterogeneities were low/moderate for glucose and HOMA and moderate/high for the other variables. Conclusions The data of this systematic review and meta-analysis indicate that Brazilian women with PCOS have a worse metabolic profile than women without PCOS with no important regional differences. The prevalence of metabolic changes is intermediate in Brazil vs. other countries.

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Association of glucocorticoid receptor polymorphisms with clinical and metabolic profiles in polycystic ovary syndrome

Cited by 8 publications

References 33 publications

Glucocorticoid receptor polymorphism in obesity and glucose homeostasis

Glucocorticoid receptor polymorphism in obesity and glucose homeostasis

Prevalence of metabolic disturbances among women with polycystic ovary syndrome in different regions of Brazil

Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

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