2014
DOI: 10.6061/clinics/2014(02)11
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Abstract: OBJECTIVE:To evaluate the effect of blocking the angiotensin II AT-1 receptor by the systemic administration of candesartan on the expression of intercellular adhesion molecule-1 in the sclera and choroid of hypercholesterolemic rabbits.METHODS:New Zealand rabbits were divided into 3 groups, as follows: GI, which was fed a rabbit standard diet; GII, which was fed a hypercholesterolemic diet; and GIII, which received hypercholesterolemic diet plus candesartan. Samples of the rabbits' sclera and choroid were the… Show more

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Cited by 7 publications
(11 citation statements)
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References 31 publications
(47 reference statements)
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“…In another in vivo study, candesartan exerted anti‐inflammatory effects via inhibiting the expression of TLR2 and TLR4 (Dasu et al, ), which have been shown to promote atherosclerosis in animal models (Shinohara et al, ). Torres et al () investigated the effects of candesartan treatment in hypercholesterolemic rabbits and found reduced expression of ICAM‐1 and consequent macrophage accumulation in the sclera and choroid. Hadi et al () have reported that candesartan reduces cytokine (TNF‐α, IL‐6, and IL‐1β) and chemokine levels (MCP‐1) as well as plasma lipid profile including total cholesterol, triglycerides, and LDL‐C, while also increasing plasma HDL‐C levels in treated rabbits.…”
Section: Ras Pharmacological Inhibitors In the Treatment Of Inflammatory Diseasesmentioning
confidence: 99%
See 1 more Smart Citation
“…In another in vivo study, candesartan exerted anti‐inflammatory effects via inhibiting the expression of TLR2 and TLR4 (Dasu et al, ), which have been shown to promote atherosclerosis in animal models (Shinohara et al, ). Torres et al () investigated the effects of candesartan treatment in hypercholesterolemic rabbits and found reduced expression of ICAM‐1 and consequent macrophage accumulation in the sclera and choroid. Hadi et al () have reported that candesartan reduces cytokine (TNF‐α, IL‐6, and IL‐1β) and chemokine levels (MCP‐1) as well as plasma lipid profile including total cholesterol, triglycerides, and LDL‐C, while also increasing plasma HDL‐C levels in treated rabbits.…”
Section: Ras Pharmacological Inhibitors In the Treatment Of Inflammatory Diseasesmentioning
confidence: 99%
“…The antiatherogenic and anti-inflammatory effects of ARBs have been investigated in previous preclinical (Blessing et al, 2008;Dasu, Riosvelasco, & Jialal, 2009;Fukuda, Enomoto, Hirata, Nagai, & Sata, 2010;Ge et al, 2004;Hadi et al, 2013;Hayashi, Sasamura, Azegami, & Itoh, 2012;Johnstone et al, 2004;Li, Fu, Gao, & Ma, 2010;Shimada et al, 2011;Strawn, Chappell, Dean, Kivlighn, & Ferrario, 2000;Torres et al, 2014;Xu et al, 2007;Xu, Sharma, Li, & Zhao, 2013;Zhao et al, 2014) and clinical studies (Dandona et al, 2003;Gong, Shao, Fu, & Zou, 2015;Graninger, Reiter, Drucker, Minar, & Jilma, 2004;Hirohata et al, 2010;Hirohata et al, 2012;Janic, Lunder, Prezelj, & Šabovic, 2014;Koh et al, 2004;Navalkar, Parthasarathy, Santanam, & Khan, 2001;Rahman et al, 2002;Ramadan et al, 2016;Stumpe et al, 2007;Yamamoto et al, 2011;Yano et al, 2012). Treatment of ApoE-deficient spontaneously hyperlipidemic mice with high-dose candesartan caused a clear regression of atherosclerotic lesions by decreasing lipid-retaining proteoglycan biglycan and suppressing ACAT1 expression (Hayashi et al, 2012).…”
Section: Arbs In the Treatment Of Atherosclerosismentioning
confidence: 99%
“…The present study corroborates the findings of earlier studies that hypercholesterolaemia may induce the same events in the choroid–sclera complex. The exacerbated expression of oxidised LDL in the choroid and sclera observed in G1 rabbits could account for the increase in the expression of chemotactic molecules ( 15 ) , such as monocyte chemoattractant protein-1, adhesion molecules ( 16 ) and intercellular adhesion molecule-1, which would induce an increase in macrophage concentrations in the choroid–sclera complex and, consequently, an increase in the thickness of the choroid and sclera as observed in the present study and in other studies ( 16 , 17 , 20 , 48 ) . From the ocular point of view, it is important to note that oxidised LDL, chemotactic molecules, adhesion molecules and macrophages are associated with the physiopathogenesis of AMD and may trigger or worsen this disease ( 2 , 9 , 10 , 46 – 49 ) .…”
Section: Discussionmentioning
confidence: 99%
“…It is recognized that ICAM-1 may be even more important in promoting nephropathy associated with T2DM because its expression is not only induced by factors common to both types of diabetes, such as hyperglycemia [102], AGEs [103], hyperfi ltration [104], and OS [105], but it can also be increased by additional elements characteristic of T2DM, including hyperlipidemia [106], hyperinsulinemia [107], and elevated levels of circulating TNF- [108], which are associated with obesity [109]. In fact, the up-regulation of ICAM-1 can be observed soon after the induction of diabetes in streptozotocin (STZ)-induced diabetic rats [92,110].…”
Section: Icam-1mentioning
confidence: 99%