Evaluation of renal function and immune system cells in elderly individuals from São Paulo City

Teixeira, Daniela; Longo-Maugéri, Ieda Maria; Duarte, Yeda A. O.; Lebrão, Maria Lúcia; Bueno, Valquíria

doi:10.6061/clinics/2013(01)oa06

Cited by 8 publications

(4 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The humoral immune response of the under studiedCKDpatients was affected in agreement with [36] that depended on B-Cells decreasing and death by apoptosis due to Uremia, thereby it causes a decreasing in immunoglobulins (Igs) levels production such as IgG, IgM and IgA especially in hemodialysis patients (HD) in agreement with [37,38] .…”

Section: Discussionsupporting

confidence: 72%

The Immunity Parameters of Renal Failure Patients

Al-Khafaji¹

2020

ATMPH

View full text Add to dashboard Cite

The current study focused on the alterations of immune parameters and response of renal failure patients before hemodialysis. The study involved equal number of patients and control (n=23) from both gender and their hemodialysis treatment was done, every 72hrs to once a week.The patients serum biochemical markers revealed a significant elevation in comparison with healthy controls for BUN,SC, UA, Na + , K + , Cl -, PO 3 -3 and ALT. While there were a significant decreasedin serum albumin.The patients sera were revealed no significant differences in Ca +2 and ALP concentration P≤0.01.The humoral immune response was significantly affected in renal failure patients due to uremia, so their sera revealed significant difference via increasing in IgA concentration in comparison with IgA of healthy controls,while patients sera had a significant difference via decreasing the complement C3 concentration of renal patients in comparison with C3 of healthy controls. However, patient with low immune response were prune to infection by contagious diseases such as HBV and HCV. The patients had disorder in serum α 2 -globulinin which was at the upper normal and leads to nephrotic syndrome.Albumin-to-globulin ratio (A/G ratio) and serum total protein revealed non-significant decreasing in renal failure patients in comparison with healthy controlssera so A/G ratio represents the lower normal(0.935±0.058) while the healthy control revealed A/G ratio (1.115± 0.067). Conclusion:The patients were of CKD in which most of them had chronic inflammatory lesion (i.e., fever, pruritus andmyalgia symptoms).

show abstract

Section: Discussionsupporting

confidence: 72%

The Immunity Parameters of Renal Failure Patients

Al-Khafaji¹

2020

ATMPH

View full text Add to dashboard Cite

show abstract

“…So there are 5 stages of chronic kidney disease according to the American Kidney Foundation classification (G1-G5, K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification). Teixeira et al (2013) reported an investigation on whether there was a confirmed decline of kidney function which correlated with the changes of levels of CD4 + T, CD8 + T and B cells in older patients. It is possible to observe that G3a (GFR = 45-59 mL/min/1.73 m 2 ) under light to moderate chronic kidney insufficiency in accordance with the classification of The American Kidney Foundation was related to considerably lower median percentage of CD8 + Т-cells, while substantial distinctions were not discovered in regard to the percentage of CD4 + Т-cells, percentage of Вcells (CD19 + ) or correlations of CD4/CD8 between individuals with similar kidney functions.…”

Section: Introductionmentioning

confidence: 99%

Peculiarities of leukocyte apoptosis modulation in children with pyelonephritis

Marchenko

Бабійчук²,

Mishyna

et al. 2020

Regul. Mech. Biosyst.

View full text Add to dashboard Cite

One of the leading places among inflammatory diseases of the urinary tract of children belongs to pyelonephritis, the course of which presents in most cases as a severe infectious disease threatening the patient’s life, which is the main reason for development of chronic kidney failure. This study was conducted to compare apoptosis stages in peripheral blood of children of different age categories with pyelonephritis depending on etiological factor and complications. The problem of mechanisms underlying immune system misregulation, especially functional activity of leukocytes in children with pyelonephritis, have not been explored in recent years. Assessment of leukocytes (neutrophils) apoptosis stages in peripheral blood of children of different age categories with pyelonephritis depending on complications and etiological factor was the aim of present study. The children's peripheral blood samples were analysed and assessed using a flow cytofluorimeter. The present study demonstrates an increase of the level of apoptotic cells at an early stage of apoptosis in children of all age categories with chronic pyelonephritis, which can be explained by associations of a wide range of pathogens and the presence of sequelae. An increase in the number of apoptotic cells in the late stage of apoptosis is observed in children aged 1 month – 8 years, in children 8–18 years, the amount of apoptotic cells is reduced by 1.5 times. The study of apoptosis stages allows complete characterization of the dynamics of the apoptotic process and supplementation of the pathogenesis of pyelonephritis in children. Such studies will make it possible to affect apoptosis modulation to regulate or correct it and encourage the finding of innovative solutions in the treatment related to influence on the immune response. We conclude that enhancement of peripheral blood leukocyte apoptosis in chronic form of pyelonephritis especially in young children is due to the polyetiology of this form of pyelonephritis and the development of complications.

show abstract

“…The innate and adaptive immune responses are very well coordinated and tightly regulated. It is when this coordination and regulation fails, that diseases occur ( 2 , 3 , 5 , 6 ).…”

mentioning

confidence: 99%

Immunologists’ perspective of nephropathology

Anis¹

2016

J Nephropathol

View full text Add to dashboard Cite

Evaluation of renal function and immune system cells in elderly individuals from São Paulo City

Cited by 8 publications

References 23 publications

The Immunity Parameters of Renal Failure Patients

The Immunity Parameters of Renal Failure Patients

Peculiarities of leukocyte apoptosis modulation in children with pyelonephritis

Immunologists’ perspective of nephropathology

Contact Info

Product

Resources

About