2018
DOI: 10.5935/abc.20180263
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Abstract: BackgroundIn menopause, there is greater cellular exposure to oxidative stress, related to the decreased antioxidative effects of estrogen. These metabolic changes favor the progression of cardiovascular diseases, such as atherosclerosis. Abnormal function of the aorta - the most important artery - is associated with many cardiovascular diseases. Collagen, especially types I and III, is one of the most important aortic wall components and it can be affected by many factors, including menopause. The 8-OHdG is o… Show more

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Cited by 4 publications
(4 citation statements)
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“…Animal models in general have long been the cornerstone for cardiovascular research. Small mammals such as mice and rats, among other available species, stood out for several advantages such as short life cycles and low maintenance cost(Maifrino et al., 2019). However, there are many relevant morphophysiological differences between small and large mammals, including humans, that make extrapolation of data inaccurate and inconsistent (Spannbauer et al., 2019).…”
Section: Introductionmentioning
confidence: 99%
“…Animal models in general have long been the cornerstone for cardiovascular research. Small mammals such as mice and rats, among other available species, stood out for several advantages such as short life cycles and low maintenance cost(Maifrino et al., 2019). However, there are many relevant morphophysiological differences between small and large mammals, including humans, that make extrapolation of data inaccurate and inconsistent (Spannbauer et al., 2019).…”
Section: Introductionmentioning
confidence: 99%
“…112 The main MMPs involved in cardiovascular diseases are MMP-2 and MMP-9. 41,42 We have shown recently that the mechanostimulation of smooth muscle cells provokes hypermethylation of the TIMP1 promotor, resulting in a decrease of TIMP1 transcription and translation in conjunction with an increased matrix remodeling enzymatic activity.…”
Section: Mmps and Ectopic Vascular Calcificationmentioning
confidence: 99%
“…Aerobic exercise is recommended in a nonpharmacological fashion for the prevention and treatment of diseases associated with weight gain (e.g., dyslipidemia). 1,[10][11][12] However, a few studies evaluated the direct effects of aerobic exercise in adipose tissue when associated with estrogen deprivation and dyslipidemia.…”
Section: Introductionmentioning
confidence: 99%