Exercise and Garlic Modulate microRNAs Involved in Diabetic Cardiopathy

Lima, A. R. R.

doi:10.5935/abc.20180259

Cited by 2 publications

(3 citation statements)

References 15 publications

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“…Cardiac, vascular, and kidney-associated diabetic complications are the most harmful. 20 , 21 TLR4 signaling can activate the transcription and translation of TNF-α, IL-6, and IL-12, causing inflammatory responses and inducing liver and kidney injuries. 19 , 22 , 23 Activation of NF-κB in the tissues and organs of diabetic rats resulted in up-regulation of TNF-α and IL-1 expression.…”

Section: Introductionmentioning

confidence: 99%

Role of TLR4/MyD88/NF-κB signaling in heart and liver-related complications in a rat model of type 2 diabetes mellitus

et al. 2021

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Aims To analyze expression of members of the Toll-like receptor (TLR)4/myeloid differentiation primary response 88 (MyD88)/nuclear factor (NF)-κB signaling pathway in the heart and liver in a rat model of type 2 diabetes mellitus (T2DM). Our overall goal was to understand the underlying pathophysiological mechanisms. Methods We measured fasting blood glucose (FBG) and insulin (FINS) in a rat model of T2DM. Expression of members of the TLR4/MyD88/NF-κB signaling pathway as well as downstream cytokines was investigated. Levels of mRNA and protein were assessed using quantitative real-time polymerase chain reaction and western blotting, respectively. Protein content of tissue homogenates was assessed using enzyme-linked immunosorbent assays. Results Diabetic rats had lower body weights, higher FBG, higher FINS, and higher intraperitoneal glucose tolerance than normal rats. In addition, biochemical indicators related to heart and liver function were elevated in diabetic rats compared with normal rats. TLR4 and MyD88 were involved in the occurrence of T2DM as well as T2DM-related heart and liver complications. TLR4 caused T2DM-related heart and liver complications through activation of NF-κB. Conclusions TLR4/MyD88/NF-κB signaling induces production of tumor necrosis factor-α, interleukin-6, and monocyte chemoattractant protein-1, leading to the heart- and liver-related complications of T2DM.

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Section: Introductionmentioning

confidence: 99%

Role of TLR4/MyD88/NF-κB signaling in heart and liver-related complications in a rat model of type 2 diabetes mellitus

et al. 2021

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“…Ferreira et al (2020) emphasize the importance of practicing physical exercises with adequate intensity and volume of time, so that benefits such as reducing NCDs and the risk of death from cardiovascular diseases are significant to health. This is corroborated by Lima et al (2011) when they point out in their results that exercises performed at higher intensities enhance the parameters of cardiac autonomic modulation in adolescents when compared with exercises performed at an intensity considered moderate.…”

Section: Authorsmentioning

confidence: 52%

“…Physical activity as leisure during adolescence can be an effective way to reduce the risks of comorbidities in this period of life, however, to stimulate adherence to the practice of physical activity, some aspects should be taken into consideration such as the encouragement of parents, physical education teachers and the availability of safe places close to home suitable for such practices. (FARIAS JUNIOR et al, 2012) According to Lima et al (2011) sessions promote beneficial changes in cardiac autonomic modulation, which can be enhanced when these activities are performed at higher but controlled intensities. Other beneficial aspects of the practice of strength training by adolescents that can be listed are the increase in muscle mass, strength gain, power, muscular endurance, physical conditioning, regulation of adiposity indexes and also numerous benefits to mental health (PINTO; PEREIRA, 2021).…”

Section: Resultsmentioning

confidence: 99%