Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio
            and Myocardial Bridge

Enhoş, Asım; Coşansu, Kahraman; Huyut, Mustafa Ahmet; Turna, Fahrettin; Karaçöp, Erdem; Bakshaliyev, Nijad; Nadir, Aydın; Оздемир, Рамазан; Uluganyan, Mahmut

doi:10.5935/abc.20180253

Cited by 14 publications

(16 citation statements)

References 24 publications

(37 reference statements)

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“…It has been reported that increased MHR level was associated with systemic inflammation and MHR could be used as predictive marker of future cardiovascular disease. 20 , 32 , 33 , 34 , 35 To the best of the present authors’ knowledge, MHR has not yet been evaluated in patients with psoriasis. The current study revealed that MHR levels in the patient group were higher than those of the healthy controls, and that MHR values were positively correlated with PASI score.…”

Section: Discussionmentioning

confidence: 98%

“… 20 , 32 However, HDL-C inhibits monocyte activities, impedes the transformation of monocytes to macrophages, and eliminates cholesterol from these cells, which leads to a restricted inflammatory response. 20 , 32 , 33 , 34 For this reason, it is reasonable to combine these two parameters into a single index (MHR) as an inflammatory marker. It has been reported that increased MHR level was associated with systemic inflammation and MHR could be used as predictive marker of future cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Şirin

Korkmaz

Erturan

et al. 2020

Anais Brasileiros de Dermatologia

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Background Psoriasis is a chronic systemic inflammatory disease frequently associated with serious comorbidities. Objectives To investigate the systemic inflammatory burden in psoriasis and to assess the correlation between traditional and novel inflammatory markers and the severity of the disease. Methods This cross-sectional study was conducted on 60 patients with psoriasis vulgaris and 50 healthy volunteers. Data including demographics, Psoriasis Area and Severity Index scores, and laboratory results were analyzed and compared. Results Compared with the control group, the psoriatic patients had significantly higher high sensitive C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, leukocyte, neutrophil, neutrophil-to-lymphocyte ratio, monocyte to high density lipoprotein (HDL) cholesterol ratio, and aspartate aminotransferase levels, and significantly lower HDL cholesterol levels (p < 0.05). No significant difference was found in procalcitonin, lymphocyte, monocyte, hemoglobin, red blood cell distribution width, platelet, mean platelet volume, platelet distribution width, lymphocyte-to-monocyte ratio, anti-cyclic citrullinated peptide, glucose, alanine aminotransaminase, blood urea nitrogen, creatinine, triglyceride, total cholesterol, and LDL cholesterol levels between the two groups (p > 0.05). The Psoriasis Area and Severity Index score was positively correlated with high-sensitivity C-reactive protein, serum amyloid A, and monocyte to HDL cholesterol ratio, and negatively correlated with lymphocyte-to-monocyte ratio (p < 0.05). Study limitations This was a single-center study with relatively limited numbers of patients and controls. Conclusions The data show that high sensitivity C-reactive protein, serum amyloid A, erythrocyte sedimentation rate, neutrophil-to-lymphocyte ratio, and monocyte to HDL cholesterol ratio can be used as markers of systemic inflammation in patients with psoriasis. Moreover, high sensitivity C-reactive protein, serum amyloid A, monocyte to HDL cholesterol ratio and lymphocyte-to-monocyte ratio are closely related to the Psoriasis Area and Severity Index score, and they may be regarded as objective indicators in determining the disease severity.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Şirin

Korkmaz

Erturan

et al. 2020

Anais Brasileiros de Dermatologia

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“…A new prognostic factor in cardiovascular disease, the ratio of monocytes to high-density lipoprotein (MHR), has recently been recommended and could be used as an indicator of infl ammation. Elevated MHR levels were associated with cigarette smoking , obesity and muscular bridge diagnosed with coronary anjiography (4,14,15). The activation of monocytes and their differentiated forms into lipid-laden machropages plays a signifi cant role in the promotion of immune defense and also drives infl ammation and cardiovascular disease (1,3,9).…”

Section: Discussionmentioning

confidence: 99%

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

Abacıoğlu¹

2021

BLL

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BACKGROUND: Mitral valve prolapse (MVP) is a common disorder, affl icting 2 % to 3 % of the general population. Despite the general belief of a benign disorder, there is an increasing awareness of an association between mitral valve prolapse and sudden cardiac death from arrhythmia and also atherosclerosis. Monocyte to high density lipoprotein ratio (MHR) is a new tool for predicting infl ammation, which plays a major role in atherosclerosis. OBJECTIVE: To evaluate the relationship between MHR and the presence of MVP. METHODS: The study population consisted of 82 patients with MVP and the control group of 78 normal individuals. Transthoracic echocardiograpy was performed for all of the study population and peripheral venous blood samples were drawn for measuring MHR and other haemotological parameters. RESULTS: The patients with MVP were more likely to have higher MHR values (15.82 ± 6.01 in MVP patients and 13.30 ± 6.43 in controls; p=0.011). Monocyte counts and MHR of the MVP group were signifi cantly higher than the control group and MHR values were directly proportional with the regurgitation area. CONCLUSION: The MHR is strongly associated with MVP and regurgitation area and might be a prognostic factor for patients with MVP

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“…In this issue of the Arquivos Brasileiros de Cardiologia , Enhos et al. 5 proposed that a newly described tool for the assessment of inflammation and atherosclerosis - the relationship between monocytes and high-density lipoprotein (HDL), abbreviated as MHR (monocyte-to-HDL-cholesterol ratio) - could be associated with atherosclerosis in segments proximal to an MB. The authors studied 160 patients with MBs and without significant coronary lesions and observed that at a cut-off value of 13.55, the MHR was able to detect the presence of MBs with a 59% sensitivity, 65% specificity, and an area under the ROC curve of 0.687 (95% confidence interval 0.606-0.769, p < 0.001).…”

mentioning

confidence: 99%

“…The authors attributed this association to the occurrence of endothelial dysfunction and inflammation in patients with MB. 5…”

mentioning

confidence: 99%

A New Marker of Myocardial Bridge?

Villela

Oliveira

2018

Arquivos Brasileiros De Cardiologia

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Assessment of the Relationship between Monocyte to High-Density Lipoprotein Ratio and Myocardial Bridge

Cited by 14 publications

References 24 publications

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Evaluation of monocyte to HDL cholesterol ratio and other inflammatory markers in patients with psoriasis

Monocyte to high-density lipoprotein ratio: a prognostic factor for mitral valve prolapse?

A New Marker of Myocardial Bridge?

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