Whole-Body Vibration Training Increases Myocardial Salvage Against Acute Ischemia in Adult Male Rats

Abstract

BackgroundWhole body vibration training (WBV) is a new training program, which is safe and effective. It can be followed by the public. However, data on the safety and efficacy of vibration on myocardial ischemia reperfusion (IR) injury are lacking.ObjectiveTo examine the effect of WBV on the tolerance of the myocardium to acute IR injury in an experimental rat model.MethodsTwenty-four male Wistar rats were divided into control and vibration groups. Vibration training consisted of vertical sinusoidal whole body vibration for 30 min per day, 6 days per week, for 1 or 3 weeks (WBV1 and WBV3 groups, respectively). All the rats were submitted to myocardial IR injury. Myocardial infarct size and ischemia-induced arrhythmias were assessed. Differences between variables were considered significant when p < 0.05.ResultsNo differences were observed between the groups regarding the baseline hemodynamic parameters. Infarct size was smaller in the experimental group (control, 47 ± 2%; WBV1, 39 ± 2%; WBV3, 37 ± 2%; p < 0.05, vs. control). Vibration produced a significant decrease in the number and duration of ventricular tachycardia (VT) episodes compared to the control value. All ventricular fibrillation (VF) episodes in the vibration groups were self-limited, while 33% of the rats in the control group died due to irreversible VF (p = 0.02).ConclusionThe data showed that vibration training significantly increased cardiac tolerance to IR injury in rats, as evidenced by reduction in the infarct size and cardiac arrhythmias, and by facilitating spontaneous defibrillation.

Exercise Training Alleviates Cardiac Fibrosis through Increasing Fibroblast Growth Factor 21 and Regulating TGF-β1-Smad2/3-MMP2/9 Signaling in Mice with Myocardial Infarction

“…Exercise training has been proven to be an effective strategy of rehabilitation for MI patients [11,12]. Some studies detected the cardioprotective effects of different types of exercise models [6,7,9,10]. In this study, we confirmed that AET, RET, WBV, and ES enhanced the cardiac function of normal mice.…”

“…Ameliorating cardiac fibrosis and inhibiting cardiomyocytes apoptosis would be key therapeutic targets to improve cardiac function following MI. Increasing data from clinic and animal research suggests that exercise training is an effective strategy in improving cardiac function [6][7][8][9][10][11][12]. Exercise training has beneficial effects on preventing or reversing pathological cardiac remodeling by reducing collagen production [13].…”

Ischemic Preconditioning in Cardiac and Skeletal Muscle Induced by Exercise

“…From the therapeutic point of view the possible implications of PE, can contribute to improve the treatment of cardiovascular diseases, it has been reported that in a training protocol with vibration, increases cardiac tolerance to reperfusion injury after ischemia, decreases the size of the infarction and cardiac arrhythmias and facilitates spontaneous defibrillation [15]. These data suggest that exercise helps to regulate the participation of the electrical conduction system after a cardiac insult, the mechanisms by which this happens has not yet been elucidated.…”

Recentes Avanços na Pesquisa Experimental em Cardiologia

“…5 Mesmo atividades consideradas passivas, como a vibração de corpo inteiro, tiveram efeitos benéficos em ratos, como o aumento da tolerância à isquemia miocárdica. 6 O conjunto dos resultados contribui para o entendimento dos mecanismos pelos quais o exercício tem efeitos benéficos na prevenção e no tratamento das doenças cardiovasculares.…”