Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in
            Newborns. A Cohort Study

Lopes, Selma Alves Valente do Amaral; Guimarães, Isabel Cristina Britto; Costa, Sofia Fontes de Oliva; Acosta, Angelina Xavier; Sandes, Kyoko Abe; Mendes, Carlos Maurício Cardeal

doi:10.5935/abc.20180175

Cited by 19 publications

(18 citation statements)

References 25 publications

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“… 6) It is also known that critical CHD, especially cyanotic CHD, has a relatively high mortality rate among all CHD. 4) The majority of cyanotic CHD cases often require surgical treatment in the early days of life; however, when the birth weight is very low, it is challenging to perform surgical treatment. For this reason, cyanotic CHD in VLBW infants is expected to have a higher mortality rate than acyanotic CHD-VLBWs.…”

Section: Discussionmentioning

confidence: 99%

“…However, studies of CHD-VLBWs are insufficient to date. Past studies on preterm infants with CHD mainly included infants under 37 or 35 weeks of gestational age, 4) and most were based on insurance or big data rather than clinical data 5) 6) ; thus, the derived information cannot aid clinicians in the clinical setting. Therefore, more specific information is needed to determine whether CHD-VLBWs develop more prematurity-associated diseases than VLBW infants, which factors are related with the disease in CHD-VLBWs, which patients have a worse prognosis in cyanotic CHD, and the surgery-related prognosis.…”

Section: Introductionmentioning

confidence: 99%

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Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease

et al. 2020

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Background and Objectives This study aimed to provide morbidity and mortality information on very low birth weight (VLBW) infants with congenital heart disease (CHD-VLBWs). Methods The study used a 10-year cohort of VLBW infants from a single institution. CHD was classified according to International Classification of Diseases, Version 9, Clinical Modification. Mortality and neonatal outcomes were assessed by comparing the CHD-VLBWs with gestational age- and birth weight-matched controls. Results The prevalence of CHD-VLBWs was 7.5% (79/1,050), mean gestational age was 31.1±3.2 weeks, and mean birth weight was 1,126.2±268.3 g; 50.6% of the infants were small for the gestational age. The CHD-VLBWs more commonly had bronchopulmonary dysplasia (BPD), and the longer they were exposed to oxygen, the more frequently they developed BPD. Those with cyanotic heart disease developed severe BPD more frequently. Necrotizing enterocolitis (NEC) occurred frequently in the CHD-VLBWs and was not associated with their feeding patterns. CHD-VLBWs had a higher mortality rate; prematurity-related diseases were the leading cause of death before surgery, while heart-related problems were the leading cause of death after surgery. We found no significant difference in mortality from prematurity-related disease between the CHD-VLBWs and controls. In the subgroup analysis of CHD, the cyanotic CHD group had a higher incidence of BPD and higher mortality rate than the acyanotic CHD group. Conclusions CHD-VLBWs showed higher BPD, NEC, and mortality rates than those without CHD. There was also a higher incidence of BPD and mortality in VLBW infants with cyanotic CHD than in those with acyanotic CHD.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease

et al. 2020

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“…Lopes et al 11 and Brum et al 12 highlight that CHD is associated with a higher occurrence of fetal deaths, since it is present in up to 85% of autopsy findings, and is an outstanding major factor for causing cardiac arrest during the first two years of life. It should be highlighted that the number of deaths related to CHD is officially lower than in fact it should be.…”

Section: Discussionmentioning

confidence: 99%

Mortality due to congenital heart disease in Pernambuco from 1996 to 2016

Cabral

Guimarães

Filho

et al. 2020

Rev. Assoc. Med. Bras.

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SUMMARY BACKGROUND To determine the magnitude and temporal trends of deaths due to congenital heart disease (CHD) in Pernambuco between 1996 and 2016. METHODS This was an ecological, time-series study, involving all cases of deaths from congenital cardiovascular malformations in the state of Pernambuco, from 1996 to 2016, using data from DATASUS, SINASC and SIM. RESULTS There were 3,584 deaths from congenital cardiovascular malformations amongst individuals aged 0 to 14 years, of which 81.94% were concentrated in children aged under one year. The infant mortality rate (IMR) presented a linear growth trend of 0.4645 per year (p <0.01). The cause-of-death code Q24 (other congenital malformations of the heart) was present in 72.54% of the death records and 48.17% of the deaths occurred in infants aged between 28 and 364 days of life. The highest occurrence of deaths was identified in children with low birth weight (500 and 1,499g), male, premature, children of mothers without schooling, in deliveries at home (p <0.05). CONCLUSIONS Congenital heart disease still represents a public health problem as a cause of death, particularly in the first year of life, with IMR in a linear growth trend. Deaths from CHD were more prevalent in male children, born prematurely, with low birth weight, born to mothers with low schooling and deliveries without medical care.

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“…En relación con los embarazos múltiples, una publicación reciente reporta que las lesiones congénitas cardiacas en embarazos gemelares monocoriónicos se asocian a un riesgo 47% mayor en comparación con embarazos únicos, 3 lo cual, considerando el riesgo habitual que se encuentra entre 1-4%, no es un incremento significativo. 4 Lopes y colaboradores describieron en un estudio de población de gemelos un riesgo de 3.1 mayor (con intervalo de confianza 95% 1.5-6.4) de presentar coartación aórtica neonatal en esta población, 5 lo que representa una patología a considerar en un recién nacido gemelar con choque cardiogénico temprano.…”

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Reparación de cardiopatía congénita crítica en el prematuro

Realpe¹,

Aguilar²,

Darszon³

et al. 2021

Acta Médica Grupo Ángeles

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Síganos en Twitter: @actaMHA INTRODUCCIÓNLos defectos cardiacos son las malformaciones más frecuentes al nacimiento, se estima a nivel mundial una incidencia de 10-12 niños por cada 1,000 nacidos vivos. 1 Esto implica que, si en nuestro país hay un poco más de 2 millones de Reparación de cardiopatía congénita crítica en el prematuroRepair of critical congenital heart disease in prematurity

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Mortality for Critical Congenital Heart Diseases and Associated Risk Factors in Newborns. A Cohort Study

Cited by 19 publications

References 25 publications

Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease

Morbidity and Mortality of Very Low Birth Weight Infants with Congenital Heart Disease

Mortality due to congenital heart disease in Pernambuco from 1996 to 2016

Reparación de cardiopatía congénita crítica en el prematuro

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