Microcirculation and Cardiovascular Diseases

Tibiriçá, Eduardo; Lorenzo, Andrea De; Oliveira, Gláucia Maria Moraes de

doi:10.5935/abc.20180149

Cited by 12 publications

(9 citation statements)

References 20 publications

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“…Studies have shown that coronary microvascular dysfunction is associated with peripheral small vessel abnormalities of kidney, retina, and brain [18][19][20]. Conversely, peripheral microvascular function can be as a model to evaluate systemic microvascular function [21]. Cremaster muscle microcirculation is representative of the peripheral microvascular bed, which is widely used to visualize in vivo blood cells interacting with the endothelium and within the vessels [22].…”

Section: Discussionmentioning

confidence: 99%

Shexiang Tongxin Dropping Pill Improves Peripheral Microvascular Blood Flow via Cystathionine-γ-Lyase

Zhang

Zhao

et al. 2019

Med Sci Monit

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Background To explore the protective effects of Shexiang Tongxin Dropping Pill (STP) in improving peripheral microvascular dysfunction in mice and to explore the involved mechanism. Material/Methods A peripheral microvascular dysfunction model was established by combined myocardial infarction (MI) and lipopolysaccharide (LPS) injection in mice. Then, the mice were randomized into a model group (n=10) or an STP group (n=10), which were treated with normal saline and STP, respectively. The cremaster muscle microvascular blood flow velocity and numbers of leukocytes adherent to the venular wall were evaluated before and after drug intervention. We assessed the expression of adhesion molecule CD11b and related transcript factor FOXO1 in leukocytes, cystathionine-γ-lyase (CSE) mRNA expression in the cremaster muscle, and mitochondrial DNA copy numbers. Results Compared with those of control mice, the cremaster microvascular blood flow velocity, cremaster CSE expression, and mitochondrial DNA copy number in mice from the model group were significantly lower and leukocyte adhesion and CD11b and FOXO1 expression were significantly higher. Intervention with STP could significantly increase the cremaster microvascular flow velocity (0.480±0.010 mm/s vs. 0.075±0.005 mm/s), mRNA expression of cremaster CSE, and mitochondrial DNA copy number, but it inhibited leukocyte adhesion and decreased leukocyte CD11b and FOXO1 expression. Conclusions STP significantly improved peripheral microcirculation, in which increased CSE expression might be the underlying mechanism.

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Section: Discussionmentioning

confidence: 99%

Shexiang Tongxin Dropping Pill Improves Peripheral Microvascular Blood Flow via Cystathionine-γ-Lyase

Zhang

Zhao

et al. 2019

Med Sci Monit

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“…Microcirculation is the main site for material exchange and metabolite discharge ( Tibirica et al, 2018 ). The microcirculation function is directly related to microcirculation capillary formation and its blood perfusion level ( Meng et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Hypoxic Training Ameliorates Skeletal Muscle Microcirculation Vascular Function in a Sirt3-Dependent Manner

Zhao

Ding

et al. 2022

Front. Physiol.

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Hypoxic training improves the microcirculation function of human skeletal muscle, but its mechanism is still unclear. Silent information regulator 2 homolog 3 (Sirt3) can improve mitochondrial function and oxidative status. We aimed to examine the role of Sirt3 in the process of hypoxic training, which affects skeletal muscle microcirculation. C57BL/6 mice were assigned to control (C), hypoxic training (HT), Sirt3 inhibitor 3-(1H-1,2,3-triazol-4-yl) pyridine (3-TYP), and 3-TYP + hypoxic training (3-TYP + HT) groups (n = 6/group). Sirt3 inhibition was induced by intraperitoneal injection of Sirt3 inhibitor 3-TYP. After 6 weeks of intervention, microcirculatory capillary formation and vasomotor capacity were evaluated using immunofluorescence, Western blot, biochemical tests, and transmission electron microscopy (TEM). Laser Doppler flowmetry was used to evaluate skeletal muscle microcirculation blood flow characteristics. Six weeks of hypoxic training enhanced skeletal muscle microcirculation function and increased microcirculatory vasodilation capacity and capillary formation. After the pharmacological inhibition of Sirt3, the reserve capacity of skeletal muscle microcirculation was reduced to varying degrees. After the inhibition of Sirt3, mice completed the same hypoxic training, and we failed to observe the microcirculation function adaptation like that observed in hypoxic training alone. The microcirculation vasodilation and the capillaries number did not improve. Hypoxic training improved skeletal muscle microcirculation vasodilation capacity and increased skeletal muscle microcirculation capillary density. Sirt3 is involved in the adaptation of skeletal muscle microcirculation induced by hypoxic training.

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“…The small arteries and capillaries are continuously subjected to high pressure from the macrocirculatory system. [7,8]…”

Section: Discussionmentioning

confidence: 99%

“…However, the assessment still relies on the expertise of an experienced intensive care unit physician. [7,37] As a result, skin assessments can not be used on their own to guide clinical resuscitation.…”

Section: Discussionmentioning

confidence: 99%

Research progress on microcirculatory disorders in septic shock: A narrative review

Wang,

Ding,

Wang

et al. 2024

Medicine

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Hemodynamic coherence plays a critical role in the outcomes of septic shock. Due to the potential negative consequences of microcirculatory disorders on organ failure and clinical outcomes, the maintenance of a balance between the macrocirculation and microcirculation is a topic of significant research focus. Although physical methods and specialized imaging techniques are used in clinical practice to assess microcirculation, the use of monitoring devices is not widespread. The integration of microcirculation research tools into clinical practice poses a significant challenge for the future. Consequently, this review aims to evaluate the impact of septic shock on the microcirculation, the methods used to monitor the microcirculation and highlight the importance of microcirculation in the treatment of critically ill patients. In addition, it proposes an evaluation framework that integrates microcirculation monitoring with macrocirculatory parameters. The optimal approach should encompass dynamic, multiparametric, individualized, and continuous monitoring of both the macrocirculation and microcirculation, particularly in cases of hemodynamic separation.

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Microcirculation and Cardiovascular Diseases

Cited by 12 publications

References 20 publications

Shexiang Tongxin Dropping Pill Improves Peripheral Microvascular Blood Flow via Cystathionine-γ-Lyase

Shexiang Tongxin Dropping Pill Improves Peripheral Microvascular Blood Flow via Cystathionine-γ-Lyase

Hypoxic Training Ameliorates Skeletal Muscle Microcirculation Vascular Function in a Sirt3-Dependent Manner

Research progress on microcirculatory disorders in septic shock: A narrative review

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