Physical Activity and Lipid Profile in the ELSA-Brasil Study

Abstract

BackgroundRegular physical activity (PA) induces desirable changes in plasma levels of high- and low-density lipoproteins (HDL and LDL, respectively) and triglycerides (TG), important risk factors for cardiometabolic diseases. However, doubts whether intensity and duration have equivalent benefits remain.ObjectiveTo assess the association of PA intensity and duration with HDL, LDL and TG levels.MethodsCross-sectional study with 12,688 participants from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline, who were not on lipid-lowering medication. After adjustment for important covariates, multiple linear regression was used to assess the association of PA intensity and duration with HDL, LDL and TG (natural logarithm) levels.ResultsBoth moderate and vigorous PA and PA practice ≥ 150 min/week were significantly associated with higher HDL and lower TG levels. Vigorous PA was associated with lower LDL only on univariate analysis. After adjustments, moderate and vigorous PA increased mean HDL level by 0.89 mg/dL and 1.71 mg/dL, respectively, and reduced TG geometric mean by 0.98 mg/dL and 0.93 mg/dL, respectively. PA practice ≥ 150 min/week increased mean HDL level by 1.05 mg/dL, and decreased TG geometric mean by 0.98 mg/dL.ConclusionOur findings reinforce the benefits of both PA parameters studied on HDL and TG levels, with a slight advantage for vigorous PA as compared to the recommendation based only on PA duration.

The Association of Ideal Cardiovascular Health and Atherogenic Index of Plasma in Rural Population: A Cross-Sectional Study from Northeast China

“…Study found that the reduction in TG levels was associated with higher physical activity intensity, but not with physical activity frequency [37]. Another study reinforced the benefits of physical activity on HDL and TG levels, with a slight advantage for vigorous physical activity as compared to physical activity duration of 150 min/week [39]. In our study, occupational physical activity intensity was used to access the status of physical activity and could provide approximations of ideal, intermediate, and poor physical activity recommended by the AHA.…”

Altered composition and functional profile of high-density lipoprotein in leprosy patients

“…Initially, it was observed that Mb pre-MDT patients (n = 8) compared to healthy controls (n = 12) presented reduced HDL-cholesterol concentrations with values varying between 21-39, min-max mg/dL. A worrying fact, since the Brazilian Longitudinal Multicentric Study of Adult Health (ELSA Brazil) [55] classified as desirable levels of HDL-cholesterol �40 mg/dL for men and �50 mg/dL for women. These data are in agreement with recent findings from Silva et al (2018) and Negera et al (2018), which also observed lower levels of HDL-cholesterol in Mb patients compared to Pb and HC [56,57].…”

Could Omega 3 Fatty Acids Preserve Muscle Health in Rheumatoid Arthritis?

“…Lipid profile Omega 3 fatty HDL-c levels [102] More exercise is associated with smaller HDL-P, fewer large HDL-P and reduced mean HDL-size [130] TNF-α inhibitors TC and HDL-c levels [131] Omega 3 fatty circulating oxidized LDL-c [105][106][107] Correlation between the intensity of physical activity and HDL levels [132] 3 months anti-TNF-α treatment TC levels [133] DHA and EPA LDL particle size in hypertensive type 2 diabetes patients and with a hypertriglyceridemia [103,104] Inverse correlation between the intensity of physical activity and TG and LDL levels [132] TNF-α inhibition anti-inflammatory properties of HDL-c [134] Table 2. Cont.…”

“…Further work should be performed to explore the relevance of multimodal strategies, including the consideration of other nutrients such as protein but also physical activity and/or specific medications (Table 2). Physical activity is known to improve TG and HDL-c serum levels [132], and helps to preserve lean body mass, muscle anabolic response and muscle function in RA patients [136][137][138]. On the other hand, an optimized protein intake seemed to have beneficial effects on muscle protein metabolism, muscle mass and quality.…”