Correlation of Insulin Resistance with Anthropometric Measures and Blood Pressure in Adolescents

Morais, Polyana; Sousa, Ana Luíza Lima; Jardim, Thiago de Souza Veiga; Nascente, Flávia Miquetichuc Nogueira; Mendonça, Karla Lorena; Póvoa, Thaís Inácio Rolim; Carneiro, Carolina de Souza; Ferreira, Vanessa Roriz; Souza, Weimar Kunz Sebba Barroso de; Jardim, Paulo César Brandão Veiga

doi:10.5935/abc.20160041

Cited by 16 publications

(20 citation statements)

References 34 publications

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“…Mechanisms explaining the effect of obesity on male fertility include abnormal reproductive hormone levels, increased release of adipose-derived hormones and adipokines associated with obesity, and other physical problems including sleep apnea and increased scrotal temperatures [ 39 ]. In our study, the correlation between pairs of clinical features of the study population was positive between HOMA-IR and waist circumference, BMI, SBP, fasting glucose, and fasting insulin, in accordance with previous reports [ 40 ].…”

Section: Discussionsupporting

confidence: 93%

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children

Cardenas-Vargas

Nava

Garza‐Veloz

et al. 2018

International Journal of Endocrinology

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Obesity is considered the main risk factor associated with the development of insulin resistance (IR). The aim of this study was to evaluate the influence of obesity on puberty onset and IR in Mexican children. A total of 378 children (189 boys and 189 girls) aged 8–14 years participated in the study. IR was estimated using the homeostasis model assessment for IR (HOMA-IR). The mean fasting glucose (FG) and basal insulin levels were 82 mg/dl and 11.0 μIU/ml in boys and 77.3 mg/dl and 12.3 μIU/ml in girls (P < 0.05). Subjects with obesity at Tanner stages II–V showed increased FG levels (P < 0.05). In boys with obesity, there was a decrease in HOMA-IR in Tanner stage IV and differences in age between boys with normal weight and those with obesity in Tanner V, being older the boys with obesity. Obesity in children and adolescents was associated with higher HOMA-IR values. In boys with obesity, IR increased at the end of pubertal maturation, with a delay in puberty. These findings should be considered on the establishment of IR cutoff values for pubertal population in Mexico and in the establishment of strategies to prevent the health problems related to obesity.

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Section: Discussionsupporting

confidence: 93%

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children

Cardenas-Vargas

Nava

Garza‐Veloz

et al. 2018

International Journal of Endocrinology

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“…(25) On the other hand, the correlation of HOMA-IR with the BMI percentile (r=0.198; p=0.037) found in this study is lower than that reported with anthropometric parameters in adolescents from Jalisco, Mexico (BMI: r=0.27; p<0.001), Brazil (BMI: r=0.366; p=0.031) and Chile (BMI: r=0.327; p<0.0001). (26)(27)(28) According to the body weight analysis, the overweight and obese group had higher insulin and HOMA-IR levels than the normal weight group (p=0.010 and p=0.015), trend that has been reported in adolescents from Peru and Venezuela. (29,30) For several years, IR has been described as a high impact factor for the alteration of the level of triglycerides and HDL cholesterol, lipids closely related to the development of metabolic syndrome in both adult and adolescent population.…”

Section: Discussionmentioning

confidence: 67%

Correlation of HOMA-IR with BMI-for-age percentile in children and adolescents from the Soconusco region of Chiapas, Mexico

et al. 2019

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Introduction: Insulin resistance (IR) is a major risk factor for developing diabetes mellitus type 2 and cardiovascular diseases. In pediatrics, morbidity and mortality associated with these diseases highlights the diagnostic importance of IR for primary care.Objective: To determine Homeostatic Model Assessment Insulin Resistance (HOMA-IR) values and their correlation with BMI-for-age percentile in children and adolescents of the Soconusco region of Chiapas, Mexico.Materials and methods: Cross-sectional study. Overweight and obesity prevalence was determined based on the Body Mass Index (BMI) percentile of 112 children (5-19 years old). Glucose and fasting insulin values were quantified and used for estimation of HOMA-IR.Results: The combined prevalence of obesity and overweight was 66%, with insulin (p=0.010) and HOMA-IR (p=0.015) values higher than those of the normal weight group. The HOMA-IR values correlated positively with age (r=0.636), weight (r=0.569), height (r=0.578) and BMI percentile (r=0.198).Conclusions: In the study population, HOMA-IR has a moderately significant correlation with an increase in BMI percentile.

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“…The same cut-off value was used by authors in Košice (Slovakia) in a group of 224 high school students with an average age of 18 years and found only a 13.9% prevalence of IR [50]. The IR prevalence in a relatively small sample of Brazilian children (n=162) aged 12-18 years was slightly higher, 23.5% at the same cut-off point of 3.16, but at overweight/obesity prevalence of 45.7% [51]. However, if we used the lowest recommended cut-off values [47], the prevalence of IR would increase to 53.7% (males) and 68.3% (females).…”

Section: Discussionmentioning

confidence: 99%

The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14–18-Year-Old Slovak Adolescents

Jurkovičová¹,

Hirošová²,

Vondrová³

et al. 2020

Preprint

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The prevalence of cardiometabolic risk factors has increased in Slovakian adolescents as a result of serious lifestyle changes. This cross-sectional study aimed to assess the prevalence of insulin resistance (IR) and the associations with cardiometabolic and selected lifestyle risk factors in a sample of Slovak adolescents. In total, 2,629 adolescents (45.8% males) aged between 14 and 18 years were examined in the study. Anthropometric parameters, blood pressure, and resting heart rate were measured, fasting venous blood samples were analysed, and HOMA-IR was calculated. The mean HOMA-IR was 2.45±1.91 without a significant intersexual difference. IR (cut-off point for HOMA-IR=3.16) was detected in 18.6% of adolescents (19.8% males, 17.6% females). IR was strongly associated with overweight/obesity (especially central) and with almost all monitored cardiometabolic factors, except for TC and systolic BP in females. The multivariate model selected variables such as low level of physical fitness, insufficient physical activity, breakfast skipping, a small number of daily meals, frequent consumption of sweetened beverages, and low educational level of fathers as the significant risk factors of IR in adolescents. Recognizing the main lifestyle risk factors and early IR identification is important in terms of the performance of preventive strategies. Weight reduction, regular physical activity, and healthy eating habits can improve insulin sensitivity and decrease the incidence of metabolic syndrome, type 2 diabetes, and CVD in adulthood.

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Correlation of Insulin Resistance with Anthropometric Measures and Blood Pressure in Adolescents

Cited by 16 publications

References 34 publications

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children

The Influence of Obesity on Puberty and Insulin Resistance in Mexican Children

Correlation of HOMA-IR with BMI-for-age percentile in children and adolescents from the Soconusco region of Chiapas, Mexico

The Prevalence of Insulin Resistance and the Associated Risk Factors in a Sample of 14–18-Year-Old Slovak Adolescents

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