Lipid Tetrad Index (LTI) and Lipid Pentad Index (LPI) in Healthy Subjects

Morais, Charles Augusto Dos Santos; Oliveira, Samuel Henrique Vieira; Lima, Luciana Moreira

doi:10.5935/abc.20130048

Cited by 3 publications

(3 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Only a few studies are available to the best of our knowledge, which have evaluated LPI and LTI in healthy individuals. [ 29 ] Although LPI values were higher in children of premature CAD patients as compared to the children of normal healthy individuals but to the best of our knowledge, LPI is not tested in the premature CAD patients for the assessment of lipid risk factors. In this study, we have compared this index in cases and of premature CAD with the healthy individuals.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Bansal

Agarwal

2016

J Lab Physicians

View full text Add to dashboard Cite

Introduction:The high prevalence, severity, and prematurity of coronary artery disease (CAD) in the Indian population cannot be completely explained by the conventional lipid parameters and the existing lipid indices.Aims and Objectives:To calculate newly defined advanced atherogenic index (AAI) in premature CAD patients and compare it between cases and controls and Correlate its values with the existing indices.Material and Methods:One hundred and twenty premature CAD patients and an equal number of age and sex matched healthy individuals were included in this study. Lipid profile and nonconventional lipid parameters like oxidized Low density lipoprotein (OX LDL), small dense LDL (SD LDL), lipoprotein (a) apolipoprotein B (Apo B), and apolipoprotein A1 (Apo A1) were estimated and their values were used to define AAI and existing lipid indices like AI, lipid tetrad index (LTI) and lipid pentad index (LPI).Results:The mean age of cases and controls was 37.29 + 4.50 and 36.13 + 3.53 years, respectively. The value of AAI was highly significant in cases (3461.22 ± 45.20) as compared to controls (305.84 ± 21.80). AAI has shown better statistical significance and correlation (P < 0.0001, r = 0.737) as compared to the earlier indices such as AI (P < 0.01, r = 0.52), LTI (P < 0.001, r = 0.677) and LPI (P < 0.001, r = 0.622) in premature CAD. Kolmogorov D statistic and cumulative distribution function plot has shown that AAI can discriminate cases and controls more accurately as compared to the earlier indices.Conclusion:Statistically AAI appears to be a better marker of consolidated lipid risk in premature CAD patients as compared to the earlier indices.

show abstract

Section: Discussionmentioning

confidence: 99%

“…A study by Morais et al . [ 29 ] showed a positive correlation between LTI and LDL which is important risk factor for the pathogenesis of CAD but LDL is not included in the calculation of this index.…”

Section: Discussionmentioning

confidence: 99%

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Bansal

Agarwal

2016

J Lab Physicians

View full text Add to dashboard Cite

show abstract

“…The risk for CVD was estimated using LTI and LPI ( 14 ) and modified Risk Score for identifying young individuals with a high probability of having advanced atherosclerotic lesions, reported by McMahan et al ( 15 ). According to risk score values, we have additionally divided the children into Low risk group (score lower or equal to 4 points), Medium risk group (5–8 points) and Higher risk group (above 8 points).…”

Section: Methodsmentioning

confidence: 99%

Cardiovascular Risk Factors In 7–13 Years Old Children From Vojvodina (Serbia)

Dželajlija¹,

Spasić

Kotur‐Stevuljević

et al. 2016

Journal of Medical Biochemistry

View full text Add to dashboard Cite

SummaryBackgroundAtherosclerosis is a chronic inflammatory disease which starts early in life and depends on many factors, an important one being dyslipoproteinemia. According to several studies, atherosclerotic plaques or their precursors could be seen in children younger than 10 years. During later life, interaction with a sedentary way of life, as well as unhealthy nutrition, smoking, alcohol consumption, obesity and family history of cardiovascular disease cause the burden of atherosclerotic disease.MethodsStudy included 624 children (316 boys, 308 girls), aged from 7–13 years. We analysed socio-demographic data (BMI, blood pressure, cardiovascular family history, smoking status), as well as lipid status with lipoprotein little a-Lp(a), and apolipoproteins: Apo AI, Apo B-100 for all children. This enabled us to calculate new atherogenic indices Tg/HDL-c, lipid tetrad index (LTI) and lipid pentad index (LPI). Cardiovascular risk for later life was estimated by using modified Risk Score for Young Individuals (RS), which divided the subjects according to the score level: low, medium and higher risk.ResultsThe older children (13 y) had better lipid status than the younger children, i.e. significantly lower total cholesterol, LDL-C, triglycerides and non-HDL-C concentration and significantly higher HDL-C concentration than the younger children and this was in accordance with the RS level. Children with a positive family history of CV disease had significantly higher Lp(a) concentration and blood pressure. LPI was significantly higher in children with a higher RS.ConclusionsThe results of our work could be used for cardiovascular risk assessment in apparently healthy children to provide preventive measures which could control the changeable risk factors.

show abstract

Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism

Bansal

Suri

Suryan

et al. 2022

Hormone Molecular Biology and Clinical Investigation

View full text Add to dashboard Cite

Objectives The objective of this study is to estimate lipid parameters in subclinical hypothyroidism and correlate it with TSH. Methods Forty newly diagnosed cases of subclinical hypothyroidism and Forty age and gender-matched healthy controls were recruited for the study. Blood samples were collected from them and serum lipid profile (i.e. HDL, LDL, TG, serum total cholesterol) of the subjects was estimated by standard photometric methods in a fully auto-analyzer (MINDRAY BS-300) using commercially available kits and VLDL cholesterol was calculated using the Friedewald’s formula. While serum Ox-LDL, Lipoprotein A, Apolipoprotein A1 and Apo B were estimated by using commercial kit based on enzyme-linked immmunosorbent assay. Results The parameters such as Oxidized low-density lipoprotein (Ox-LDL), lipoprotein (a), apolipoprotein A1, apolipoprotein B and small dense lipoprotein (sd LDL) were significantly increased in subclinical hypothyroid cases when compared with the control subjects (p<0.0001). In present study results showed significant positive correlations of serum thyroid stimulating hormone (TSH) with Ox-LDL (r=0.85, p<0.01), sd LDL (r=0.71, p<0.01). Conclusions The present study focuses on the role of Ox-LDL, sd-LDL Lipoprotein A, Apolipoprotein A1 and Apo B that are sensitive indicators of atherogenic dyslipidemia in subclinical hypothyroidism and can serve as a better & novel risk factor for CAD.

show abstract

Lipid Tetrad Index (LTI) and Lipid Pentad Index (LPI) in Healthy Subjects

Cited by 3 publications

References 7 publications

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Advanced Atherogenic Index for the Assessment of Consolidated Lipid Risk in Premature Coronary Artery Disease Patients in India

Cardiovascular Risk Factors In 7–13 Years Old Children From Vojvodina (Serbia)

Level of non-conventional lipid parameters and its comparative analysis with TSH in subclinical hypothyroidism

Contact Info

Product

Resources

About