Patients with pure dermatomyositis/polymyositis and anti-PM/Scl autoantibody resembling anti-synthetase syndrome

Alves, Samara Pereira; Silva, Marilda Guimarães; Borges, Isabela Bruna Pires; Shinjo, Samuel Katsuyuki

doi:10.5935/medicalexpress.2018.mo.002

Cited by 3 publications

(1 citation statement)

References 27 publications

(75 reference statements)

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“…This pattern of onset with isolated symptoms and incomplete forms of the disease as well as the similarity of ASS to other autoimmune diseases can result into possible diagnostic mistakes for patients with ASS. Alves et al (18) observed that patients with dermatomyositis and polymyositis with the presence of autoantibodies anti-PM/Scl demonstrated a pattern of clinical presentation similar to that of ASS, confusing the diagnosis, which is the reason we also elected to exclude patients with anti-PM/ Scl autoantibodies in this study. When a patient presents with joint involvement, the pattern is a peripheral symmetric polyarthritis, similar to that of rheumatoid arthritis (19).…”

Section: Original Papermentioning

confidence: 99%

The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces

et al. 2020

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The antisynthetase syndrome (ASS) is clinically characterized by fever, myositis, interstitial lung disease, joint involvement, mechanic’s hands, or Raynaud’s phenomenon, and the presence of antisynthetase autoantibodies. These clinical manifestations may not occur simultaneously. Therefore, the aim of this study was to analyze the sequence in which these clinical manifestations can develop at the onset of ASS. This retrospective, single-center cohort study enrolled 55 ASS patients. Their mean age at the onset of ASS symptoms was 42.3±11.8 years. There was a predominance of female patients (75.9%) and white patients (72.7%). At initial presentation, 41.8% of the patients had fever, 43.6% had joint symptoms, 38.2% had myositis, 36.4% had interstitial lung disease, 18.2% had Raynaud’s phenomenon, and 16.4% had mechanic’s hands. Subsequent clinical symptoms emerged at varying time points. In two out of 55 cases, joint, muscle, and lung manifestations developed simultaneously. The median time between the onset of symptoms and the complete ASS clinical manifestation was 19.9 (4.0-60.2) months; whereas, the timeframe between the onset of symptoms and the ASS diagnosis was 29.0 (11.0-63.0) months. The confounding misdiagnoses interfering with the initial diagnosis were polymyositis (52.7%), dermatomyositis (29.1%), nonspecific interstitial pneumopathy (23.6%), rheumatoid arthritis (18.2%), and others (10.9%). Clinical features at the onset of ASS are highly variable. Consequently, confounding factors can lead to significant delays for the final and definitive diagnosis of ASS. Therefore, ASS should be considered a differential diagnosis in patients with initial symptoms of joint, lung, and/or muscle involvements, as well as fever, mechanic’s hands, and/or Raynaud’s phenomenon manifestations.

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Section: Original Papermentioning

confidence: 99%

The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces

et al. 2020

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Aplicabilidade de biomarcadores em miopatias autoimunes sistêmicas

Shinjo

Souza

2019

Rev Paul Reumatol

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As miopatias autoimunes sistêmicas são um grupo heterogêneo de doenças raras que acometem primariamente a musculatura esquelética. Entretanto, outros órgãos e sistemas podem estar afetados. Entre diversos biomarcadores disponíveis, serão abordados no presente estudo os autoanticorpos miosite-específicos e miosite-associados que têm sido caracterizados e correlacionados com diversas manifestações fenotípicas dessas doenças. Unitermos: Autoanticorpos. Autoimunidade. Biomarcadores. Miopatias inflamatórias. Miosite.

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Dermatomiosite Na Infância: Um Desafio Diagnóstico

Amorim,

Ferraz,

Peruchi

et al. 2023

Rev. Contemp.

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Introdução: Dermatomiosite é uma miopatia sistêmica autoimune de acometimento muscular, cutâneo e, conforme o indivíduo, articular, cardíaco, pulmonar e gastrointestinal. Sabe-se que o sexo feminino é o mais afetado, em especial na idade média de 40 anos. A Dermatomiosite Juvenil (DMJ) costuma afetar principalmente crianças entre 5 e 14 anos, embora possa ocorrer em outras faixas etárias durante a infância e adolescência. As meninas têm o dobro do risco de desenvolver a DMJ em comparação com os meninos. Atualmente, o grande desafio da doença é o diagnóstico, que muitas vezes necessita de biópsia cutânea ou muscular para corroborar com a hipótese. Pode haver achados característicos na eletroneuromiografia e alterações na dosagem laboratorial de desidrogenase lática. Por fim, a terapia mais frequentemente utilizada são os corticoides. Metodologia: Trata-se de revisão sistemática de literatura acerca de quadros diagnosticados de dermatomiosite na infância. Dentre os 16 artigos levantados nas plataformas Scielo, Pubmed e nas publicações dos Anais Brasileiros de Dermatologia, 9 foram selecionados. Os descritores foram: “dermatomiosite”, “dermatomiosite na infância”, “diagnósticos dermatológicos na infância” e “doenças reumatológicas na infância”. Discussão: Para diagnosticar a DMJ, além da presença de características típicas na pele como o heliotropo e as pápulas de Gottron, são necessários três dos seguintes quatro critérios: fraqueza muscular simétrica na região próxima às articulações, aumento dos níveis sanguíneos de enzimas musculares, alterações eletromiográficas características e resultados compatíveis em biópsia muscular. Conclusão: Diante das manifestações clínicas descritas, independentemente do sexo ou da idade, é importante solicitar os exames supracitados no intuito de confirmar ou descartar a possibilidade diagnóstica de dermatomiosite. Assim, será possível promover maior cuidado e qualidade de vida aos acometidos pela doença.

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Patients with pure dermatomyositis/polymyositis and anti-PM/Scl autoantibody resembling anti-synthetase syndrome

Cited by 3 publications

References 27 publications

The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces

The clinical manifestations at the onset of antisynthetase syndrome: A chameleon with multiple faces

Aplicabilidade de biomarcadores em miopatias autoimunes sistêmicas

Dermatomiosite Na Infância: Um Desafio Diagnóstico

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