Effects of surfactants on preterm infant lungs

Pacifici, Gian Maria

doi:10.5935/medicalexpress.2015.02.06

Cited by 2 publications

(1 citation statement)

References 38 publications

(29 reference statements)

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“…However, when this does not occur, PNBs will present respiratory distress, which can be mild or even very severe depending on gestational age and the severity of the hyaline membrane disease caused by surfactant dysfunction. This condition can cause difficulty in differentiating the diagnosis of COVID-19, when NBs present risk factors, such as when a mother is diagnosed with COVID-19 (21) .…”

Section: Discussionmentioning

confidence: 99%

Um olhar para o recém-nascido com covid-19: revisão integrativa

et al. 2021

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Objetivo: Investigar as manifestações clínicas, fatores de risco, tratamento e prevenção dos recém-nascidos acometidos pela COVID-19 relatados na literatura científica. Método: Trata-se de revisão integrativa, cuja pergunta foi “Quais as manifestações clínicas, possíveis fatores de risco, tratamento e prevenção dos recém-nascidos acometidos pela COVID-19 têm sido relatados na literatura científica?” Os descritores utilizados foram newborn, COVID-19, SARS-CoV-2 e as bases de dados: LILACS, MEDLINE e Biblioteca Virtual em Saúde. A busca ocorreu em maio de 2020. Resultados: Os cuidados de prevenção para o novo Coronavírus ao recém-nascido são fundamentais, visto que, ainda existem muitas lacunas relacionadas ao tratamento. Foram identificadas diferentes manifestações clínicas no recém-nascido, o que sugere continuidade de estudos. Discussão: Tendo em vista os aspectos analisados, atualizações contínuas sobre abordagens terapêuticas são necessárias para orientar os profissionais. Conclusão: Os poucos estudos incluídos acerca do acometimento da COVID-19 na população neonatal confirmam a necessidade de serem realizadas novas investigações.

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Section: Discussionmentioning

confidence: 99%

Um olhar para o recém-nascido com covid-19: revisão integrativa

et al. 2021

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Temporal effects of caffeine on intrapulmonary shunt in preterm ventilated infants

Kaltsogianni,

Bhat,

Greenough

et al. 2024

Journal of Perinatal Medicine

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Objectives We hypothesized that caffeine would be associated with a transient reduction in the right-to-left shunt and VA/Q. We aimed to explore the temporal effects of caffeine on right-to-left shunt, ventilation perfusion ratio (VA/Q) and shift of the oxyhaemoglobin dissociation curve (ODC) in premature ventilated infants. Methods Retrospective cohort study at a tertiary neonatal unit of infants born at less than 31 weeks of gestation that were mechanically ventilated on day three of life. The non-invasive method of the ODC was used to determine the right-to-left shunt, VA/Q and shift before and at 1, 4 and 20 h after a maintenance dose of caffeine citrate. Results 21 infants were included with a median (range) gestational age of 27 (23.7–30.7) weeks. The median shunt percentage was significantly reduced, compared to baseline at 1 h (8 (range: 7–9) % vs. 4 (range: 0–6) %, p=0.042) and 4 h post caffeine administration (8 (range: 7–9) % vs. 0 (range: 0–3) %, p=0.042), but the VA/Q and the right shift of the ODC did not differ significantly between these time points. At 20 h, there were no significant differences between these indices compared to baseline values. Conclusions Caffeine led to a transient decrease in intrapulmonary shunt from one to 4 h after administration and this may be due to its diuretic action.

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Effects of surfactants on preterm infant lungs

Cited by 2 publications

References 38 publications

Um olhar para o recém-nascido com covid-19: revisão integrativa

Um olhar para o recém-nascido com covid-19: revisão integrativa

Temporal effects of caffeine on intrapulmonary shunt in preterm ventilated infants

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