Intestinal transplantation: evolution and current status

Cunha-Melo, José Renan; Costa, Guilherme

doi:10.5935/medicalexpress.2014.06.05

Cited by 6 publications

(3 citation statements)

References 78 publications

(69 reference statements)

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“…This could be as a result of differences in breed and diet. The clinical signs attributable to short bowel syndrome by other workers are diarrhea, fluid and electrolytes abnormalities and weight loss [2,[18][19][20][21][22]. The clinical signs attributable to short bowel syndrome mentioned in their report is in agreement with our findings as our dogs that had 70% of their small intestinal tract resected manifested these clinical signs.…”

Section: Discussionsupporting

confidence: 92%

Establishing Short Bowel Syndrome in Nigerian Dogs

Kisani

Adeyanju

Elsa

et al. 2017

International Journal of Veterinary Sciences Research

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Article HistoryDetermining the relationship between percentage resection and development of short bowel syndrome is important as it provides information on the expected outcome of the resection carried out which will enable the surgeon to prepare adequately to manage such patients. Ten adult Nigerian indigenous dogs with mean body weight 11.2 kg were used in this study. The animals were premedicated with atropine (0.04mg/kg) and xylazine (1mg/kg) intramuscularly. Anaesthesia was induced with thiopentone sodium (10mg/kg) intravenously. The abdominal cavity was entered through the ventral midline incision. Three animals each were subjected to 50% and 60% small intestinal resection while four animals were subjected to 70% small intestinal resection. The animals subjected to 50% and 60% intestinal resection did not manifest signs of short bowel syndrome. However, the animals subjected to 70% small intestinal resection manifested clinical signs attributable to short bowel syndrome. The animals subjected to 50% and 60% small intestinal resection had remnant small intestinal tract of up to 100cm while dogs that underwent 70% resection had remnant small intestinal bowel length of less than 100 cm. It is therefore, concluded that 70% small intestinal length resection is the minimum that can produce short bowel syndrome in Nigerian dogs and animals with remnant small bowel length of less than 100 cm after undergoing resection will come down with short bowel syndrome. Contribution/Originality:This study is one of very few studies which have investigated the crown-rump length, total small intestinal length and the percentage small intestinal resection that will result in short bowel syndrome in Nigerian dogs.

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Section: Discussionsupporting

confidence: 92%

Establishing Short Bowel Syndrome in Nigerian Dogs

Kisani

Adeyanju

Elsa

et al. 2017

International Journal of Veterinary Sciences Research

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“…Over the last 2 decades, visceral transplantation has evolved into the standard of care for patients with irreversible intestinal failure who no longer can be maintained on intravenous nutrition and for those with complex abdominal pathology (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12). The number of intestinal transplants in USA peaked in 2007 then declined over next 5 years then has been increasing over last 3 years (13,14).…”

Section: Introductionmentioning

confidence: 99%

Long-term survival in visceral transplant recipients in the new era: A single-center experience

Elsabbagh

Hawksworth

Khan

et al. 2019

American Journal of Transplantation

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There is a paucity of data on long-term outcomes following visceral transplantation in the contemporary era. This is a single-center retrospective analysis of all visceral allograft recipients who underwent transplant between November 2003 and December 2013 with at least 3-year follow up data. Clinical data from a prospectively maintained database was used to assess outcomes including patient and graft survival. Of 174 recipients, 90 were adults and 84 were pediatric patients. Types of visceral transplants were isolated intestinal transplant (56.3%), combined liver intestinal transplant (25.3%), multi-visceral transplant (16.1%) and modified multivisceral transplant (2.3%). 3-, 5-, and 10-year overall patient survival was 69.5%, 66%, and 63%, respectively, while 3-, 5-, and 10-year overall graft survival was 67%, 62%, and 61%, respectively. In multivariable analysis, significant predictors of survival included pediatric recipient (P= 0.001), donor/recipient weight ratio less than 0.9 (P= 0.008), no episodes of severe acute rejection (P= 0.021), cold ischemia time less than 8 hours (P= 0.014) and shorter hospital stay (P= 0.0001). In conclusion, visceral transplantation remains a good option for treatment of end stage intestinal failure with parenteral nutritional complications. Proper graft selection, shorter cold ischemia time and improvement of immunosuppression regimens could significantly improve the long-term survival.

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“…In intestinal transplants, advancements in therapy have contributed to a decrease in mortality rates [11]. Despite these advances, long-term patient and graft survival remains substantially lower compared to other organ transplants, except for lung transplants [20], with all-cause mortality rates of nearly 44% at 5 years [13].…”

Section: Introductionmentioning

confidence: 99%

Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis

Ameyaw,

Boateng,

Annor

et al. 2024

Ann Transplant

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Background Long-term patient survival after intestinal transplantation (IT) remains low compared with other organ transplants despite years of advancement in clinical experience. While patients with extremely high or low body mass index (BMI) are often considered ineligible for IT, the impact of BMI on post-transplant IT survival remains understudied. Material/Methods Using the United Network for Organ Sharing Standard Transplant database, we conducted a retrospective cohort study on patients who underwent IT between April 11, 1994, and September 29, 2021. We assessed the association of recipient and donor BMI at transplant with post-transplant mortality using Kaplan-Meier survival curves and univariate and multivariate Cox regression analyses. Results A total of 1541 patients were included in our final sample. Of these patients, 806 were females (52.5%) and most were in the normal-weight BMI subgroup (54.2%). Obese class II (mean; 36.8±10.92 years) and underweight patients (mean; 37.6±13.37 years) were significantly younger than patients in other BMI categories. The adjusted multivariate model demonstrated an increased risk of mortality in underweight IT recipients compared to normal-weight IT recipients (aHR=1.25, 95% confidence interval [CI], 1.02–1.54; P =0.032). There was no significant association between donor BMI categories and survival in IT recipients. Conclusions Recipient BMI below normal is associated with an increased risk of mortality after intestinal transplantation and represents a potentially modifiable patient characteristic to improve survival outcomes.

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Intestinal transplantation: evolution and current status

Cited by 6 publications

References 78 publications

Establishing Short Bowel Syndrome in Nigerian Dogs

Establishing Short Bowel Syndrome in Nigerian Dogs

Long-term survival in visceral transplant recipients in the new era: A single-center experience

Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A United Network for Organ Sharing Database Analysis

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