Factors related to chronic pain in institutionalized elderly

Abstract

BACKGROUND AND OBJECTIVES: Inflammation is a defense response of the body to a cellular damage caused by physical, chemical or biological agents, which triggers, among other factors, pain. Although inflammation plays an important role in the protection and regeneration of tissue injury, inflammatory pain results in decreased quality of life. In view of this, the development of safe and less invasive forms for the treatment of inflammatory pain is of great importance. The objective of this study was to evaluate the antihyperalgesic potential of the culture supernatant of keratinocytes and human fibroblasts in an experimental model of inflammatory hyperalgesia. METHODS: Evaluation of carrageenan induced inflammatory hyperalgesia through the use of electronic von Frey in animal models treated with culture supernatant of keratinocytes and fibroblasts. RESULTS: Local administration of naloxone, a nonselective opioid antagonist, in peripheral tissue, has been observed to inhibit the antihyperalgesic effect of the keratinocyte culture supernatant. Fibroblast culture supernatant on days 1 and 3 reverses for 2 hours the carrageenan induced inflammatory hyperalgesia, which is mediated by µ opioid agonist. CONCLUSION: This study indicates that culture supernatant of fibroblasts and keratinocytes is capable of inducing antinociception in inflammatory hyperalgesia, mediated by the release of Evaluation of the keratinocytes or fibroblasts culture supernatant in an inflammatory hyperalgesia model Avaliação do sobrenadante da cultura de queratinócitos ou fibroblastos em modelo de hiperalgesia inflamatória

Prevalência de dor crônica em idosos: revisão integrativa da literatura / Prevalence of chronic pain in the older adults: an integrative literature review

“…Evidenciada de maneira subjetiva ao envolver mecanismos físicos, psíquicos e culturais, a dor crônica interfere em mudanças psicológicas que podem resultar em dificuldades no desenvolvimento de papeis diários (25) de idosos com dor crônica quando comparado com idosos sem dor crônica, o que afeta diretamente a saúde com uma imposição de sofrimento desnecessário (26). O conhecimento das interações entre os fatores sociodemográficos e de saúde em relação à dor crônica pode enfatizar e facilitar o entendimento tanto da necessidade de uma abrangência multimodal ou interdisciplinar quanto à compreensão da complexa rede de interações entre as variáveis ao longo da vida, pois o fardo negativo da dor crônica leva ao isolamento social e à dificuldade de mobilidade do indivíduo (27) e quando não controlada, pode causar impactos prejudiciais sobre a saúde, como alterações psicossomáticas (28).…”