Prevention and control of chronic post-amputation pain of extremities: systematic review

Abstract

BACKGROUND AND OBJECTIVES: Inflammation is a defense response of the body to a cellular damage caused by physical, chemical or biological agents, which triggers, among other factors, pain. Although inflammation plays an important role in the protection and regeneration of tissue injury, inflammatory pain results in decreased quality of life. In view of this, the development of safe and less invasive forms for the treatment of inflammatory pain is of great importance. The objective of this study was to evaluate the antihyperalgesic potential of the culture supernatant of keratinocytes and human fibroblasts in an experimental model of inflammatory hyperalgesia. METHODS: Evaluation of carrageenan induced inflammatory hyperalgesia through the use of electronic von Frey in animal models treated with culture supernatant of keratinocytes and fibroblasts. RESULTS: Local administration of naloxone, a nonselective opioid antagonist, in peripheral tissue, has been observed to inhibit the antihyperalgesic effect of the keratinocyte culture supernatant. Fibroblast culture supernatant on days 1 and 3 reverses for 2 hours the carrageenan induced inflammatory hyperalgesia, which is mediated by µ opioid agonist. CONCLUSION: This study indicates that culture supernatant of fibroblasts and keratinocytes is capable of inducing antinociception in inflammatory hyperalgesia, mediated by the release of Evaluation of the keratinocytes or fibroblasts culture supernatant in an inflammatory hyperalgesia model Avaliação do sobrenadante da cultura de queratinócitos ou fibroblastos em modelo de hiperalgesia inflamatória

Atuação Multidisplinar Na Promoção Da Saúde

“…Após a amputação a dor pode se apresentar tanto no membro residual ou coto, quanto no membro fantasma, que é caracterizado pela sensação dolorosa relacionado ao membro ou parte dele, que foi removido na cirurgia. (Xavier, et al, 2020) A dor é definida com uma experiência sensitiva e emocional desconfortável que está associada a uma lesão tecidual real ou em potencial. De acordo com seu surgimento fisiopatológica é classificada em cinco grupos principais: a nociceptiva que corresponde a uma dor constante ou intermitente, a neuropática que é um tipo de dor crônica que ocorre quando os nervos sensitivos do Sistema Nervoso Central e/ou periférico são feridos ou danificados, a disfuncional que ocorre quando há alterações neuroquímicas em vias que levam os estímulos sensitivos até a medula e cérebro e também naquelas envolvidas na modulação do processo doloroso, psicogênica atribuída aos fatores psicológicos na percepção de dor e mista.…”

Pain management in the postoperative period of amputation surgeries: A scoping review

“…Thus, as it is a complex condition, it requires knowledge and skills from health professionals to perform adequate pain management, since it is a singular and subjective topic, which requires an individualized care plan. Among the strategies, you can choose to use drugs and non‐pharmacological measures, but there is still no consensus on the most effective and efficient way to manage this event (Milosevic et al, 2021; Xavier et al, 2020).…”