Severe Mitral Regurgitation by Hyperthyroidism in the Absence of Left Ventricular Dilatation

Jorge, Antônio José Lagoeiro; Martins, Wolney de Andrade; Gripp, Eliza de Almeida; Almeida, Breno Macedo de; Figueroa, Camila Cezário Rocha Paz; Sabino, Cíntia Lobo

doi:10.5935/2359-4802.20170089

Cited by 2 publications

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“…In addition, there is blood volume expansion and increase in enddiastolic pressure and cardiac workload. 15 Around half of patients with thyrotoxicosis are admitted due to cardiovascular complications. 16 Studies have shown the prevalence of HF in up to 68% 17 and incidence of 14% 18 of patients with thyrotoxicosis.…”

Section: Discussionmentioning

confidence: 99%

Challenges in the Management of Thyrotoxicosis Associated with Atrial Fibrillation and Heart Failure: Two Case Reports

Sadiq

Chamba

2021

Clin Med Insights Case Rep

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Background: Thyrotoxicosis is a clinical syndrome with high amounts of free thyroid hormone levels causing elevated thyroid hormone function in body tissues. Prolonged effects of free thyroid hormones may lead to cardiac complications such as atrial fibrillation (AF) and heart failure (HF). Case 1: A 31-year-old female, was admitted due to difficulty in breathing, generalised body swelling and jaundice. She was dyspnoeic with an irregular heart rate, and presented with abnormal vitals, liver and thyroid function tests which were diagnostic for thyroid storm. She was managed over 32 days in-hospital stay with carbimazole, propranolol, hydrocortisone, digoxin and furosemide. Unfortunately, she was readmitted 6 months later with worsened HF symptoms and passed away. Case 2: A 57-year-old female, was admitted due to difficulty in breathing, bilateral lower limb swelling and jaundice. She was tachypnoeic with an irregular heart rate, and presented with abnormal liver enzymes and thyroid function tests which were diagnostic for thyrotoxicosis. She was managed with carbimazole, propranolol, digoxin and furosemide, and was discharged on the 6th hospital day. Conclusion: Prolonged untreated thyrotoxicosis increases the risk of AF and HF. Early and monitored treatment and follow-up of hyperthyroidism is key to the management of AF and HF in achieving a better outcome.

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Section: Discussionmentioning

confidence: 99%

Challenges in the Management of Thyrotoxicosis Associated with Atrial Fibrillation and Heart Failure: Two Case Reports

Sadiq

Chamba

2021

Clin Med Insights Case Rep

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“…The time frame for improvement in MR with antithyroid therapy can be highly variable, from days to as long as 9 months in previous reports. 5 , 7 , 10 For patients with chordal rupture, however, definitive surgical intervention has been required. 5 , 7 A heart team discussion was held regarding the most appropriate treatment of the severe MR.…”

Section: Question 7: How Is Severe Mitral Regurgitation Secondary To ...mentioning

confidence: 99%

A “Grave” Case of Mitral Regurgitation

et al. 2022

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Severe Mitral Regurgitation by Hyperthyroidism in the Absence of Left Ventricular Dilatation

Cited by 2 publications

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Challenges in the Management of Thyrotoxicosis Associated with Atrial Fibrillation and Heart Failure: Two Case Reports

Challenges in the Management of Thyrotoxicosis Associated with Atrial Fibrillation and Heart Failure: Two Case Reports

A “Grave” Case of Mitral Regurgitation

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