Nebivolol in preventing atrial fibrillation following coronary surgery in patients over 60 years of age

Abstract

ObjectivePostoperative atrial fibrillation is a common complication after cardiac surgery, with an incidence as high as 20-50%. Increased age is associated with a significant increase in postoperative atrial fibrillation risk. This common complication is associated with higher morbidity and mortality rates. The aim of this study was to assess the efficacy of nebivolol in preventing atrial fibrillation following coronary artery bypass surgery in patients over 60 years of age.MethodsIn this prospective randomized study, 200 patients who were candidates for elective coronary artery bypass surgery were divided into two groups. The first group was administered with nebivolol and the second group was administered with metoprolol. Treatment was initiated four days prior to surgery, and patients were monitored for atrial fibrillation until discharge. Forty-one patients recieved 50 mg metoprolol succinate daily, which was initiated minimum 4 days before surgery.ResultsDemographic data were similar in both groups. The incidence of postoperative atrial fibrillation in both groups was similar, with no significant difference being identified [n=20 (20%); n=18 (18%), P=0.718; respectively]. There were not any mortality at both groups during study. Inotropic agent requirement at ICU was similar for both groups [n=12 (12%), n=18 (18%), P=0.32].ConclusionWe compared the effectiveness of nebivolol and metoprolol in decreasing the incidence of postoperative atrial fibrillation, and determined that nebivolol was as effective as metoprolol in preventing postoperative atrial fibrillation at patients. Nebivolol may be the drug of choice due to its effects, especially after elective coronary artery bypass surgery.

Zastosowanie bursztynianu metoprololu w leczeniu niewydolności serca oraz migotania przedsionków: przegląd systematyczny

“…W przypadku metoprololu ten efekt kliniczny jest spowodowany selektywną blokadą receptorów β-adrenergicznych. Natomiast nebiwolol dodatkowo indukuje syntezę tlenku azotu w śródbłonku [33]. W badaniu Erdil i wsp.…”

“…W badaniu Erdil i wsp. wybrano metoprolol jako lek porównawczy do nebiwololu w zapobieganiu AF po zabiegu operacyjnym na tętnicach wieńcowych [33]. Faktycznie, metoprolol jest już od dekad stosowany w zapobieganiu oraz leczeniu pooperacyjnego AF, natomiast w swoim badaniu Erdil i wsp.…”

“…Faktycznie, metoprolol jest już od dekad stosowany w zapobieganiu oraz leczeniu pooperacyjnego AF, natomiast w swoim badaniu Erdil i wsp. wykazali podobną skuteczność nebiwololu oraz metoprololu w tej sytuacji klinicznej [33].…”