Cardiovascular and periodontal diseases

Vieira, Reinaldo Wilson

doi:10.5935/1678-9741.20140003

Cited by 8 publications

(9 citation statements)

References 12 publications

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“…IL6 and IL1B have been reported to be associated with depression and cardiovascular disease in a number of reports by Piletz, et al [28], Vieira [29], Kohut, et al [30] and Nadrowski, et al [31]. On the other hand this is the first report wherein IL6 and IL1B have also been reported in the diabetic patients [28][29][30][31].…”

Section: Identification Of Potential Biomarkersmentioning

confidence: 55%

Network-Centric Identification of Disease Co-Occurrences: A Systems Biology Approach

Sahrawat¹,

Talwar²

2020

SJMH

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Complex diseases that occur by perturbations of molecular pathways and genetic factors result in pathophysiology of diseases. Network-centric systems biology approaches play an important role in understanding disease complexity. Diabetes, cardiovascular disease and depression are such complex diseases that have been reported to be comorbid in various epidemiological studies but there are no reports of the genetic and underlying factors which may be responsible for their reported co-occurrences. The present study was undertaken to investigate the molecular factors responsible for co-occurrence of diabetes, depression and cardiovascular disease using in-silico network systems biology approach. Genes common amongst these three diseases were retrieved from DisGeNET, a database of human diseases and their interactions were retrieved from STRING database. The resulting network containing 99 nodes (which represent genes) and 1252 edges (which represent various interactions between nodes) was analyzed using Cytoscape v: 3.7.2 and its various plug-ins i.e. ClusterONE, Cytohubba, ClueGO and Cluepedia. The hub genes identified in the present study namely IL1B, VEGFA, LEP, CAT, CXCL8, PLG, IL6, IL10, PTGS2, TLR4 and AKT1 were found to be enriched in various metabolic pathways and several mechanisms such as inflammation. These genes and their protein products may act as potential biomarkers for early detection of predisposition to diseases and potential therapeutic targets based on the common molecular underpinnings of co-occurrence of diabetes, depression and cardiovascular disease.

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Section: Identification Of Potential Biomarkersmentioning

confidence: 55%

Network-Centric Identification of Disease Co-Occurrences: A Systems Biology Approach

Sahrawat¹,

Talwar²

2020

SJMH

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“…For instance, the ischemic heart disease. There are sharing risky issues between heart diseases and periodontitis that increase the happening of these diseases include: age, male sex, diabetes, hypercholesterolemia, tobacco, obesity, and chronic infection [9]. Another signal is the inflammation caused by bacteria of dental plaque can cause inflammation in any part of the body as confirmed by increase in the C -reactive protein (CRP) as shown in table 2.…”

Section: Discussionmentioning

confidence: 99%

The possible Connection of periodontal diseases (PD) with cardiovascular disease (CVD) and prostatitis in sample of Iraqi patients

Muhsin¹

2019

MMJ

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Periodontitis is a chronic inflammation that effect the tissue that surround and support the teeth, and this is prevalent cause of teeth loss in adults while prostatitis is a comparatively common issue affecting about 12 percent of men, and it’s the most common prostate-related health issue in men under age fifty. Researches showed that the heart diseases spread in the persons that have periodontitis about 25-50{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47} higher than healthy persons. Recent studies have connected periodontal disease with plenty of systemic health risks, including heart disease and prostatitis but their results were varied. The recent study aimed to explore the linking of gum diseases with heart diseases and prostate inflammations. In total, 150 serum samples of four age groups of participants distributed as 100 (66.7{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) samples of patients with periodontitis and other 50 (33.3{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) samples of control, All patients were attending to Ibn al-Bitar hospital, teaching laboratories – Medical city and Specialized Dental Center/AL-Alwiya and the diagnosis of all cases based up on patients medical history that evaluated by qualified physicians and some other laboratory investigations. As (38.0{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) patients with heart diseases history and (58.6{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}) patients with prostatitis. Sample were analyzed for Triglycerides, Prostate-specific antigen (PSA) and CRP levels. The abnormal Triglycerides level estimated by (37.3{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}), while the elevated level of (PSA) was determined by (40.0{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). Furthermore, the prevalence of CRP seropositivity in individuals increased by (43.3{df6391716bcab23f197eab8ba5a452daee5812a1941604c42f67c7803ea6be47}). The incidence of periodontal disease (PD) was paralleled with the positivity of tested biochemical markers of cardiovascular disease (CVD) history and prostatitis respectively with high significant differences (P= 0.000). Finally, there is significant connection of PD with CVD and prostatitis, but further studies are needed, and the outcomes of this study have limitations, also the current finding encourages to review a large sample size with different age groups in order to clarify this issue.

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“…Algunos estudios presentan los productos sintetizados por las bacterias gran negativas (causantes de la periodontitis) como desencadenadores de la producción y liberación de citoquinas proinflamatorias, que inducen a una respuesta del propio hospedero, elevando los niveles de proteína C reactiva y aumentando el riesgo de enfermedades cardiovasculares, así como también las bacterias gingivalis, que están ligadas a la formación de placas de ateromas, resultando en enfermedades isquémicas, bacteremias, sepsis y endocarditis. [12][13][14][15] Otra alteración periodontal es la HG medicamentosa, presente en pacientes trasplantados. Es una condición multifactorial, pero algunos estudios presentaron la relación con la incidencia y gravedad que se asocian al uso de tacrolimo, y principalmente de ciclosporina A.…”

Section: Alteraciones Periodontalesunclassified

“…En lesiones persistentes, puede ser necesaria la sustitución de la ciclosporina por tacrolimo. [12][13][14][15][16][17] Osteonecrosis maxilar asociada al uso de medicamentos La osteoporosis y el aumento de la prevalencia de fracturas óseas se han observado en pacientes pre y post trasplante de órganos sólidos, considerándose factores predisponentes para trastornos óseos en esos individuos: uso de diuréticos de asa, heparina, deficiencia de vitamina D y hiperparatireoidismo secundario, hipogonadismo, insuficiencia renal y efectos adversos de glicocorticoides e inhibidores de calcineurina. Con los objetivos de prevenir y tratar la pérdida de la densidad mineral, los bisfosfonatos son ampliamente utilizados, ya que estos medicamentos disminuyen el turnover óseo por medio de la inhibición y apoptosis de los osteoclastos.…”

Section: Alteraciones Periodontalesunclassified

Alteraciones Bucales en Individuos en Pre y Post Trasplante Cardíaco

Affonço¹,

Soares

Caminha

et al. 2022

BJT

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Resumen: La insuficiencia cardíaca avanzada y sin éxito en tratamientos alternativos puede llevar al paciente al trasplante cardíaco. Pacientes en pre trasplante de corazón que presentan alteraciones periodontales pueden evolucionar a un cuadro infeccioso y comprometer el éxito del trasplante. Los pacientes trasplantados presentan alteraciones intrabucales asociadas a la terapia inmunosupresora, como la hiperplasia gingival y las infecciones oportunistas que merecen atención, ya que resultan en baja calidad de vida y peor pronóstico. Este trabajo buscó en la literatura las alteraciones bucales frecuentemente encontradas en pacientes con insuficiencia cardíaca en programas de trasplante y trasplantados cardíacos, poniendo en evidencia la importancia del cirujano-dentista en el equipo multidisciplinario y el seguimiento a largo plazo del paciente trasplantado. En esta revisión, se contemplaron estudios de cohorte, estudios transversales, casos de control y casos clínicos incluidos en las bases PubMed, Biblioteca Electrónica Científica Online (SciELO) y Literatura Latinoamericana y del Caribe en Ciencias de la Salud (Lilacs) de los últimos 11 años (de 2009 a 2020) y en los idiomas inglés, portugués y español. El resultado de la búsqueda puso a disposición 577 artículos, que fueron filtrados y seleccionados, de forma que contemplen todas las informaciones necesarias para el análisis estadístico. Entre los datos más relevantes en cuanto a la condición bucal de los pacientes pre trasplantados cardíacos, se observó que el 74,21 % de los individuos presentan hipertensión arterial sistémica como comorbilidad principal y el 42,69 % utilizan inmunosupresores. En cuanto al diagnóstico bucal, hay alta necesidad de tratamiento periodontal en el 75,57 % de los pacientes. En el perfil de los pacientes trasplantados, hay mayor prevalencia de diabetes mellitus (48,26 %), y todos los pacientes siguen tratamiento farmacológico, con asociación de más de un fármaco. De estos individuos, 90 % necesitan de tratamiento periodontal y el 17,34 % presentaron hiperplasia gingival. Los datos obtenidos permitieron concluir que tanto los pacientes en programa de trasplantes de corazón como los trasplantados necesitan atención especial en cuanto a los cuidados bucales, por ser susceptibles a infecciones oportunistas y presentar necesidades de cuidados periodontales, lo que sugiere que la adecuación bucal previa a los trasplantes es relevante, así como también el control de los efectos secundarios de la terapia inmunosupresora

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Cardiovascular and periodontal diseases

Cited by 8 publications

References 12 publications

Network-Centric Identification of Disease Co-Occurrences: A Systems Biology Approach

Network-Centric Identification of Disease Co-Occurrences: A Systems Biology Approach

The possible Connection of periodontal diseases (PD) with cardiovascular disease (CVD) and prostatitis in sample of Iraqi patients

Alteraciones Bucales en Individuos en Pre y Post Trasplante Cardíaco

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